Decreased coherence in the model of the dorsal visual pathway associated with Alzheimer’s disease
Abstract Decreased coherence in electroencephalogram (EEG) has been reported in Alzheimer’s disease (AD) experimentally, which could be considered as a typical electrophysiological characteristic in AD. This work aimed to investigate the effect of AD on coherence in the dorsal visual pathway by the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-30535-w |
| _version_ | 1797864794013827072 |
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| author | SiLu Yan XiaoLi Yang Hao Yang ZhongKui Sun |
| author_facet | SiLu Yan XiaoLi Yang Hao Yang ZhongKui Sun |
| author_sort | SiLu Yan |
| collection | DOAJ |
| description | Abstract Decreased coherence in electroencephalogram (EEG) has been reported in Alzheimer’s disease (AD) experimentally, which could be considered as a typical electrophysiological characteristic in AD. This work aimed to investigate the effect of AD on coherence in the dorsal visual pathway by the technique of neurocomputation. Firstly, according to the hierarchical organization of the cerebral cortex and the information flows of the dorsal visual pathway, a more physiologically plausible neural mass model including cortical areas v1, v2, and v5 was established in the dorsal visual pathway. The three interconnected cortical areas were connected by ascending and descending projections. Next, the pathological condition of loss of long synaptic projections in AD was simulated by reducing the parameters of long synaptic projections in the model. Then, the loss of long synaptic projections on coherence among different visual cortex areas was explored by means of power spectral analysis and coherence function. The results demonstrate that the coherence between these interconnected cortical areas showed an obvious decline with the gradual decrease of long synaptic projections, i.e. decrease in descending projections from area v2 to v1 and v5 to v2 and ascending projection from area v2 to v5. Hopefully, the results of this study could provide theoretical guidance for understanding the dynamical mechanism of AD. |
| first_indexed | 2024-04-09T22:58:16Z |
| format | Article |
| id | doaj.art-4d5e3fe782e040deb149356af3261559 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T22:58:16Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4d5e3fe782e040deb149356af32615592023-03-22T11:08:40ZengNature PortfolioScientific Reports2045-23222023-03-0113111310.1038/s41598-023-30535-wDecreased coherence in the model of the dorsal visual pathway associated with Alzheimer’s diseaseSiLu Yan0XiaoLi Yang1Hao Yang2ZhongKui Sun3School of Mathematics and Statistics, Shaanxi Normal UniversitySchool of Mathematics and Statistics, Shaanxi Normal UniversitySchool of Mathematics and Statistics, Shaanxi Normal UniversitySchool of Mathematics and Statistics, Northwestern Polytechnical UniversityAbstract Decreased coherence in electroencephalogram (EEG) has been reported in Alzheimer’s disease (AD) experimentally, which could be considered as a typical electrophysiological characteristic in AD. This work aimed to investigate the effect of AD on coherence in the dorsal visual pathway by the technique of neurocomputation. Firstly, according to the hierarchical organization of the cerebral cortex and the information flows of the dorsal visual pathway, a more physiologically plausible neural mass model including cortical areas v1, v2, and v5 was established in the dorsal visual pathway. The three interconnected cortical areas were connected by ascending and descending projections. Next, the pathological condition of loss of long synaptic projections in AD was simulated by reducing the parameters of long synaptic projections in the model. Then, the loss of long synaptic projections on coherence among different visual cortex areas was explored by means of power spectral analysis and coherence function. The results demonstrate that the coherence between these interconnected cortical areas showed an obvious decline with the gradual decrease of long synaptic projections, i.e. decrease in descending projections from area v2 to v1 and v5 to v2 and ascending projection from area v2 to v5. Hopefully, the results of this study could provide theoretical guidance for understanding the dynamical mechanism of AD.https://doi.org/10.1038/s41598-023-30535-w |
| spellingShingle | SiLu Yan XiaoLi Yang Hao Yang ZhongKui Sun Decreased coherence in the model of the dorsal visual pathway associated with Alzheimer’s disease Scientific Reports |
| title | Decreased coherence in the model of the dorsal visual pathway associated with Alzheimer’s disease |
| title_full | Decreased coherence in the model of the dorsal visual pathway associated with Alzheimer’s disease |
| title_fullStr | Decreased coherence in the model of the dorsal visual pathway associated with Alzheimer’s disease |
| title_full_unstemmed | Decreased coherence in the model of the dorsal visual pathway associated with Alzheimer’s disease |
| title_short | Decreased coherence in the model of the dorsal visual pathway associated with Alzheimer’s disease |
| title_sort | decreased coherence in the model of the dorsal visual pathway associated with alzheimer s disease |
| url | https://doi.org/10.1038/s41598-023-30535-w |
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