Cocaine Directly Inhibits α6-Containing Nicotinic Acetylcholine Receptors in Human SH-EP1 Cells and Mouse VTA DA Neurons

Cocaine Directly Inhibits α6-Containing Nicotinic Acetylcholine Receptors in Human SH-EP1 Cells and Mouse VTA DA Neurons

Alpha6-containing nicotinic acetylcholine receptors are primarily found in neurons of the midbrain dopaminergic (DA) system, suggesting these receptors are potentially involved in drug reward and dependence. Here, we report a novel effect that cocaine directly inhibits α6N/α3Cβ2β3-nAChR (α6*-nAChRs)...

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Bibliographic Details
Main Authors: Dejie Chen, Fenfei Gao, Xiaokuang Ma, Jason Brek Eaton, Yuanbing Huang, Ming Gao, Yongchang Chang, Zegang Ma, Taleen Der-Ghazarian, Janet Neisewander, Paul Whiteaker, Jie Wu, Quanxi Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Pharmacology
Subjects:
cocaine
nicotinic acetylcholine receptor
SH-EP1 cells
VTA, dopamine neurons, patch clamp
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00072/full

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