Myasthenia Gravis Complicated by Eosinophilic Granulomatosis with Polyangiitis: A Case Report
A 55-year-old woman with a history of allergic sinusitis was being administered cyclosporine for ptosis and diplopia due to myasthenia gravis since age 46 years. She developed painful dysesthesia that began in her feet and later spread to her palms, leading to difficulty in walking. Eosinophils were...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2022-07-01
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| Series: | Case Reports in Neurology |
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| Online Access: | https://beta.karger.com/Article/FullText/525702 |
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| author | Takahumi Uchi Shingo Konno Hideo Kihara Mari Matsushima Hideki Sugimoto Toshiaki Oharaseki Kei Takahashi Toshiki Fujioka |
| author_facet | Takahumi Uchi Shingo Konno Hideo Kihara Mari Matsushima Hideki Sugimoto Toshiaki Oharaseki Kei Takahashi Toshiki Fujioka |
| author_sort | Takahumi Uchi |
| collection | DOAJ |
| description | A 55-year-old woman with a history of allergic sinusitis was being administered cyclosporine for ptosis and diplopia due to myasthenia gravis since age 46 years. She developed painful dysesthesia that began in her feet and later spread to her palms, leading to difficulty in walking. Eosinophils were markedly increased in the peripheral blood. Nerve conduction studies revealed mononeuritis multiplex. Nerve biopsy showed the infiltration of eosinophils in the superior neurovasculature. Based on these findings, eosinophilic granulomatous polyangiitis was diagnosed. Methylprednisolone pulse therapy was followed by oral prednisolone. Two weeks after treatment, the patient could do normal daily activities without assistance. In patients with myasthenia gravis having a history of allergic diseases, considering EGPA as a complication and monitoring prior changes in blood data are necessary for early detection before apparent tissue damage. |
| first_indexed | 2024-12-10T17:29:41Z |
| format | Article |
| id | doaj.art-4d64744b620f4e6fac3f9e68dab0351d |
| institution | Directory Open Access Journal |
| issn | 1662-680X |
| language | English |
| last_indexed | 2024-12-10T17:29:41Z |
| publishDate | 2022-07-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Neurology |
| spelling | doaj.art-4d64744b620f4e6fac3f9e68dab0351d2022-12-22T01:39:44ZengKarger PublishersCase Reports in Neurology1662-680X2022-07-0114231431910.1159/000525702525702Myasthenia Gravis Complicated by Eosinophilic Granulomatosis with Polyangiitis: A Case ReportTakahumi Uchi0Shingo Konno1Hideo Kihara2Mari Matsushima3Hideki Sugimoto4Toshiaki Oharaseki5Kei Takahashi6Toshiki Fujioka7Department of Neurology, Toho University Ohashi Medical Center, Tokyo, JapanDepartment of Neurology, Toho University Ohashi Medical Center, Tokyo, JapanDepartment of Neurology, Toho University Ohashi Medical Center, Tokyo, JapanDepartment of Neurology, Toho University Ohashi Medical Center, Tokyo, JapanDepartment of Neurology, Toho University Ohashi Medical Center, Tokyo, JapanDepartment of Pathology, Toho University Ohashi Medical Center, Tokyo, JapanDepartment of Pathology, Toho University Ohashi Medical Center, Tokyo, JapanDepartment of Neurology, Toho University Ohashi Medical Center, Tokyo, JapanA 55-year-old woman with a history of allergic sinusitis was being administered cyclosporine for ptosis and diplopia due to myasthenia gravis since age 46 years. She developed painful dysesthesia that began in her feet and later spread to her palms, leading to difficulty in walking. Eosinophils were markedly increased in the peripheral blood. Nerve conduction studies revealed mononeuritis multiplex. Nerve biopsy showed the infiltration of eosinophils in the superior neurovasculature. Based on these findings, eosinophilic granulomatous polyangiitis was diagnosed. Methylprednisolone pulse therapy was followed by oral prednisolone. Two weeks after treatment, the patient could do normal daily activities without assistance. In patients with myasthenia gravis having a history of allergic diseases, considering EGPA as a complication and monitoring prior changes in blood data are necessary for early detection before apparent tissue damage.https://beta.karger.com/Article/FullText/525702eosinophilic granulomatosis with polyangiitismononeuropathy multiplexmyasthenia gravismethylprednisolone plus therapycyclosporine |
| spellingShingle | Takahumi Uchi Shingo Konno Hideo Kihara Mari Matsushima Hideki Sugimoto Toshiaki Oharaseki Kei Takahashi Toshiki Fujioka Myasthenia Gravis Complicated by Eosinophilic Granulomatosis with Polyangiitis: A Case Report Case Reports in Neurology eosinophilic granulomatosis with polyangiitis mononeuropathy multiplex myasthenia gravis methylprednisolone plus therapy cyclosporine |
| title | Myasthenia Gravis Complicated by Eosinophilic Granulomatosis with Polyangiitis: A Case Report |
| title_full | Myasthenia Gravis Complicated by Eosinophilic Granulomatosis with Polyangiitis: A Case Report |
| title_fullStr | Myasthenia Gravis Complicated by Eosinophilic Granulomatosis with Polyangiitis: A Case Report |
| title_full_unstemmed | Myasthenia Gravis Complicated by Eosinophilic Granulomatosis with Polyangiitis: A Case Report |
| title_short | Myasthenia Gravis Complicated by Eosinophilic Granulomatosis with Polyangiitis: A Case Report |
| title_sort | myasthenia gravis complicated by eosinophilic granulomatosis with polyangiitis a case report |
| topic | eosinophilic granulomatosis with polyangiitis mononeuropathy multiplex myasthenia gravis methylprednisolone plus therapy cyclosporine |
| url | https://beta.karger.com/Article/FullText/525702 |
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