Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner

Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner

Abstract Background Magnetic resonance spectroscopy (MRS) studies have identified elevated levels of the phospholipid precursor phosphocholine (PC) and phosphoethanolamine (PE) as metabolic hallmarks of cancer. Unusually, however, PC and PE levels are reduced in mutant isocitrate dehydrogenase 1 (ID...

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Bibliographic Details
Main Authors: Pavithra Viswanath, Marina Radoul, Jose Luis Izquierdo-Garcia, Hema Artee Luchman, J. Gregory Cairncross, Russell O. Pieper, Joanna J. Phillips, Sabrina M. Ronen
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Cancer & Metabolism
Subjects:
IDH1 mutation
2-Hydroxyglutarate
Metabolic reprogramming
Magnetic resonance spectroscopy
Phosphocholine
Phosphoethanolamine
Online Access:http://link.springer.com/article/10.1186/s40170-018-0178-3

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