Association of the Preoperative Neutrophil-to-ymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid Cancer
BackgroundSeveral inflammatory biomarkers, especially a high preoperative neutrophil-to-lymphocyte count ratio (NLR) and platelet-to-lymphocyte count ratio (PLR), are known to be indicator of poor prognosis in several cancers. However, very few studies have evaluated the significance of the NLR and...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2015-12-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-494.pdf |
| _version_ | 1819049770596958208 |
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| author | Sang Mi Kim Eun Heui Kim Bo Hyun Kim Jong Ho Kim Su Bin Park Yoon Jeong Nam Kang Hee Ahn Min Young Oh Won Jin Kim Yun Kyung Jeon Sang Soo Kim Yong Ki Kim In Ju Kim |
| author_facet | Sang Mi Kim Eun Heui Kim Bo Hyun Kim Jong Ho Kim Su Bin Park Yoon Jeong Nam Kang Hee Ahn Min Young Oh Won Jin Kim Yun Kyung Jeon Sang Soo Kim Yong Ki Kim In Ju Kim |
| author_sort | Sang Mi Kim |
| collection | DOAJ |
| description | BackgroundSeveral inflammatory biomarkers, especially a high preoperative neutrophil-to-lymphocyte count ratio (NLR) and platelet-to-lymphocyte count ratio (PLR), are known to be indicator of poor prognosis in several cancers. However, very few studies have evaluated the significance of the NLR and PLR in papillary thyroid cancer (PTC). We evaluated the association of the preoperative NLR and PLR with clinicopathological characteristics in patients with PTC.MethodsThis study included 1,066 female patients who underwent total thyroidectomy for PTC. Patients were stratified into 4 quartiles by preoperative NLR and PLR. And the combination of preoperative NLR and PLR was calculated on the basis of data obtained value of tertile as follows: patients with both an elevated PLR and an elevated NLR were allocated a score of 2, and patients showing one or neither were allocated a score of 1 or 0, respectively.ResultsThe preoperative NLR and PLR were significantly lower in patients aged ≥45 years and in patients with Hashimoto's thyroiditis. The PLR was significantly higher in patients with tumor size >1 cm (P=0.021).When the patients were categorized into the aforementioned four groups, the group with the higher preoperative PLR was found to have a significantly increased incidence of lateral lymph node metastasis (LNM) (P=0.018). However, there are no significant association between the combination of preoperative NLR and PLR and prognostic factors in PTC patients.ConclusionThese results suggest that a preoperative high PLR were significant associated with lateral LNM in female patients with PTC. |
| first_indexed | 2024-12-21T11:37:26Z |
| format | Article |
| id | doaj.art-4d68d50dc6b3402da5bc00dc0da40650 |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-21T11:37:26Z |
| publishDate | 2015-12-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-4d68d50dc6b3402da5bc00dc0da406502022-12-21T19:05:25ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782015-12-0130449450110.3803/EnM.2015.30.4.49420849Association of the Preoperative Neutrophil-to-ymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid CancerSang Mi KimEun Heui KimBo Hyun KimJong Ho KimSu Bin ParkYoon Jeong NamKang Hee AhnMin Young OhWon Jin KimYun Kyung JeonSang Soo KimYong Ki KimIn Ju KimBackgroundSeveral inflammatory biomarkers, especially a high preoperative neutrophil-to-lymphocyte count ratio (NLR) and platelet-to-lymphocyte count ratio (PLR), are known to be indicator of poor prognosis in several cancers. However, very few studies have evaluated the significance of the NLR and PLR in papillary thyroid cancer (PTC). We evaluated the association of the preoperative NLR and PLR with clinicopathological characteristics in patients with PTC.MethodsThis study included 1,066 female patients who underwent total thyroidectomy for PTC. Patients were stratified into 4 quartiles by preoperative NLR and PLR. And the combination of preoperative NLR and PLR was calculated on the basis of data obtained value of tertile as follows: patients with both an elevated PLR and an elevated NLR were allocated a score of 2, and patients showing one or neither were allocated a score of 1 or 0, respectively.ResultsThe preoperative NLR and PLR were significantly lower in patients aged ≥45 years and in patients with Hashimoto's thyroiditis. The PLR was significantly higher in patients with tumor size >1 cm (P=0.021).When the patients were categorized into the aforementioned four groups, the group with the higher preoperative PLR was found to have a significantly increased incidence of lateral lymph node metastasis (LNM) (P=0.018). However, there are no significant association between the combination of preoperative NLR and PLR and prognostic factors in PTC patients.ConclusionThese results suggest that a preoperative high PLR were significant associated with lateral LNM in female patients with PTC.http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-494.pdfNeutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratioThyroid neoplasmsPrognosis |
| spellingShingle | Sang Mi Kim Eun Heui Kim Bo Hyun Kim Jong Ho Kim Su Bin Park Yoon Jeong Nam Kang Hee Ahn Min Young Oh Won Jin Kim Yun Kyung Jeon Sang Soo Kim Yong Ki Kim In Ju Kim Association of the Preoperative Neutrophil-to-ymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid Cancer Endocrinology and Metabolism Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Thyroid neoplasms Prognosis |
| title | Association of the Preoperative Neutrophil-to-ymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid Cancer |
| title_full | Association of the Preoperative Neutrophil-to-ymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid Cancer |
| title_fullStr | Association of the Preoperative Neutrophil-to-ymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid Cancer |
| title_full_unstemmed | Association of the Preoperative Neutrophil-to-ymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid Cancer |
| title_short | Association of the Preoperative Neutrophil-to-ymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid Cancer |
| title_sort | association of the preoperative neutrophil to ymphocyte count ratio and platelet to lymphocyte count ratio with clinicopathological characteristics in patients with papillary thyroid cancer |
| topic | Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Thyroid neoplasms Prognosis |
| url | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-494.pdf |
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