Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration
Any planarian fragment regenerates the missing head and tail in the proper end. Early activation of the Wnt/β-catenin signaling pathway changes the chromatin accessibility of the cells of the posterior-facing wound to regenerate a tail.
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-35937-y |
| _version_ | 1797945801120415744 |
|---|---|
| author | Eudald Pascual-Carreras Marta Marín-Barba Sergio Castillo-Lara Pablo Coronel-Córdoba Marta Silvia Magri Grant N. Wheeler Jose Luis Gómez-Skarmeta Josep F. Abril Emili Saló Teresa Adell |
| author_facet | Eudald Pascual-Carreras Marta Marín-Barba Sergio Castillo-Lara Pablo Coronel-Córdoba Marta Silvia Magri Grant N. Wheeler Jose Luis Gómez-Skarmeta Josep F. Abril Emili Saló Teresa Adell |
| author_sort | Eudald Pascual-Carreras |
| collection | DOAJ |
| description | Any planarian fragment regenerates the missing head and tail in the proper end. Early activation of the Wnt/β-catenin signaling pathway changes the chromatin accessibility of the cells of the posterior-facing wound to regenerate a tail. |
| first_indexed | 2024-04-10T21:00:51Z |
| format | Article |
| id | doaj.art-4d696ab5163e4238a799db2d227455bc |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T21:00:51Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4d696ab5163e4238a799db2d227455bc2023-01-22T12:18:32ZengNature PortfolioNature Communications2041-17232023-01-0114111610.1038/s41467-023-35937-yWnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regenerationEudald Pascual-Carreras0Marta Marín-Barba1Sergio Castillo-Lara2Pablo Coronel-Córdoba3Marta Silvia Magri4Grant N. Wheeler5Jose Luis Gómez-Skarmeta6Josep F. Abril7Emili Saló8Teresa Adell9Department of Genetics, Microbiology and Statistics, Universitat de Barcelona (UB) & Institute of Biomedicine of Universitat de Barcelona (IBUB)School of Biological Sciences, University of East Anglia, Norwich Research ParkDepartment of Genetics, Microbiology and Statistics, Universitat de Barcelona (UB) & Institute of Biomedicine of Universitat de Barcelona (IBUB)Department of Genetics, Microbiology and Statistics, Universitat de Barcelona (UB) & Institute of Biomedicine of Universitat de Barcelona (IBUB)Centro Andaluz de Biología del Desarollo (CABD), Universidad Pablo de OlavideSchool of Biological Sciences, University of East Anglia, Norwich Research ParkCentro Andaluz de Biología del Desarollo (CABD), Universidad Pablo de OlavideDepartment of Genetics, Microbiology and Statistics, Universitat de Barcelona (UB) & Institute of Biomedicine of Universitat de Barcelona (IBUB)Department of Genetics, Microbiology and Statistics, Universitat de Barcelona (UB) & Institute of Biomedicine of Universitat de Barcelona (IBUB)Department of Genetics, Microbiology and Statistics, Universitat de Barcelona (UB) & Institute of Biomedicine of Universitat de Barcelona (IBUB)Any planarian fragment regenerates the missing head and tail in the proper end. Early activation of the Wnt/β-catenin signaling pathway changes the chromatin accessibility of the cells of the posterior-facing wound to regenerate a tail.https://doi.org/10.1038/s41467-023-35937-y |
| spellingShingle | Eudald Pascual-Carreras Marta Marín-Barba Sergio Castillo-Lara Pablo Coronel-Córdoba Marta Silvia Magri Grant N. Wheeler Jose Luis Gómez-Skarmeta Josep F. Abril Emili Saló Teresa Adell Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration Nature Communications |
| title | Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration |
| title_full | Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration |
| title_fullStr | Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration |
| title_full_unstemmed | Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration |
| title_short | Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration |
| title_sort | wnt β catenin signalling is required for pole specific chromatin remodeling during planarian regeneration |
| url | https://doi.org/10.1038/s41467-023-35937-y |
| work_keys_str_mv | AT eudaldpascualcarreras wntbcateninsignallingisrequiredforpolespecificchromatinremodelingduringplanarianregeneration AT martamarinbarba wntbcateninsignallingisrequiredforpolespecificchromatinremodelingduringplanarianregeneration AT sergiocastillolara wntbcateninsignallingisrequiredforpolespecificchromatinremodelingduringplanarianregeneration AT pablocoronelcordoba wntbcateninsignallingisrequiredforpolespecificchromatinremodelingduringplanarianregeneration AT martasilviamagri wntbcateninsignallingisrequiredforpolespecificchromatinremodelingduringplanarianregeneration AT grantnwheeler wntbcateninsignallingisrequiredforpolespecificchromatinremodelingduringplanarianregeneration AT joseluisgomezskarmeta wntbcateninsignallingisrequiredforpolespecificchromatinremodelingduringplanarianregeneration AT josepfabril wntbcateninsignallingisrequiredforpolespecificchromatinremodelingduringplanarianregeneration AT emilisalo wntbcateninsignallingisrequiredforpolespecificchromatinremodelingduringplanarianregeneration AT teresaadell wntbcateninsignallingisrequiredforpolespecificchromatinremodelingduringplanarianregeneration |