Maternal exercise represses Nox4 via SIRT1 to prevent vascular oxidative stress and endothelial dysfunction in SHR offspring

Maternal exercise represses Nox4 via SIRT1 to prevent vascular oxidative stress and endothelial dysfunction in SHR offspring

Maternal exercise during pregnancy has emerged as a potentially promising approach to protect offspring from cardiovascular disease, including hypertension. Although endothelial dysfunction is involved in the pathophysiology of hypertension, limited studies have characterized how maternal exercise i...

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Bibliographic Details
Main Authors: Yanyan Zhang, Meiling Shan, Xiaozhen Ding, Hualing Sun, Fang Qiu, Lijun Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Endocrinology
Subjects:
maternal exercise
endothelial function
histone deacetylase
hypertension
Nox4
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1219194/full

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