Clinical and epidemiological characteristics of patients with Amyotrophic Lateral Sclerosis (ALS) in central Brazil
Objective: This study aimed to evaluate the clinical-epidemiological characteristics of patients with Amyotrophic Lateral Sclerosis (ALS) in the State of Goiás, Brazil. Methods: We conducted a descriptive cross-sectional study to assess medical records of patients with ALS followed-up at the State...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Portuguese |
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Universidade de São Paulo
2022-11-01
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| Series: | Medicina |
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| Online Access: | https://www.revistas.usp.br/rmrp/article/view/192620 |
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| author | Dhiogo da Cruz Pereira Bento Rayana Pereira Dantas de Oliveira Kamilla de Faria Santos Rômulo Morais Azevedo Lays Bernardes Minasi Yves Mauro Fernandes Ternes Angela Adamski da Silva Reis Rodrigo da Silva Santos |
| author_facet | Dhiogo da Cruz Pereira Bento Rayana Pereira Dantas de Oliveira Kamilla de Faria Santos Rômulo Morais Azevedo Lays Bernardes Minasi Yves Mauro Fernandes Ternes Angela Adamski da Silva Reis Rodrigo da Silva Santos |
| author_sort | Dhiogo da Cruz Pereira Bento |
| collection | DOAJ |
| description |
Objective: This study aimed to evaluate the clinical-epidemiological characteristics of patients with Amyotrophic Lateral Sclerosis (ALS) in the State of Goiás, Brazil. Methods: We conducted a descriptive cross-sectional study to assess medical records of patients with ALS followed-up at the State Rehabilitation and Readaptation Medical Center Dr. Henrique Santillo, Goiânia, GO, Brazil, between 2005 and 2018. In addition, we registered and created a photographic panel with the main clinical findings of ALS cases. Results: From 224 investigated patients, 51.8% were male, and 67.4% manifested the classic form of the disease. Initial symptoms were more frequent in the lower limbs (37.9%), and complications resulted in 45.5% of tracheostomy, 60.3% of gastrostomy, and 49.1% of deaths. Most patients had a five-year survival from the onset of symptoms, and no significant association between the use of non-invasive ventilation and increased survival were found. The analysis of the clinical-epidemiological characteristics showed a more extended time between the first symptoms and the diagnosis of the disease was observed. Conclusion: In this study, the time between the first symptoms and diagnosis was longer than in the literature, resulting in late treatments. In addition, there was no satisfactory result regarding survival with the use of non-invasive ventilation. Therefore, clinical-epidemiological studies of the disease in Brazil, as well as public awareness and training of professionals in recognition of ALS clinical signs will assist in early and more efficient interventions.
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| first_indexed | 2024-04-12T11:07:45Z |
| format | Article |
| id | doaj.art-4d6a85381aa542b0a7efc503c9821421 |
| institution | Directory Open Access Journal |
| issn | 0076-6046 2176-7262 |
| language | Portuguese |
| last_indexed | 2024-04-12T11:07:45Z |
| publishDate | 2022-11-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-4d6a85381aa542b0a7efc503c98214212022-12-22T03:35:41ZporUniversidade de São PauloMedicina0076-60462176-72622022-11-01553Clinical and epidemiological characteristics of patients with Amyotrophic Lateral Sclerosis (ALS) in central BrazilDhiogo da Cruz Pereira Bento0Rayana Pereira Dantas de Oliveira1Kamilla de Faria Santos2Rômulo Morais Azevedo3Lays Bernardes Minasi4Yves Mauro Fernandes Ternes5Angela Adamski da Silva Reis6Rodrigo da Silva Santos7Rehabilitation Multiprofessional Service SempRRe Girassol, Goiânia, (GO), BrazilFederal University of Goiás, Goiânia. Institute of Biological Sciences (ICB). Department of Biochemistry and Molecular Biology. Laboratory of Molecular Pathology, (GO), Brazil Federal University of Goiás, Goiânia. Institute of Biological Sciences (ICB). Department of Biochemistry and Molecular Biology. Laboratory of Molecular Pathology, (GO), Brazil Federal University of Goiás, Goiânia. Institute of Biological Sciences (ICB). Department of Biochemistry and Molecular Biology. Laboratory of Molecular Pathology, (GO), Brazil Rehabilitation Multiprofessional Service SempRRe Girassol, Goiânia, (GO), BrazilUniversidade Federal de Goiás (UFG)Federal University of Goiás, Goiânia. Institute of Biological Sciences (ICB). Department of Biochemistry and Molecular Biology. Laboratory of Molecular Pathology, (GO), Brazil Federal University of Goiás, Goiânia. Institute of Biological Sciences (ICB). Department of Biochemistry and Molecular Biology. Laboratory of Molecular Pathology, (GO), Brazil Objective: This study aimed to evaluate the clinical-epidemiological characteristics of patients with Amyotrophic Lateral Sclerosis (ALS) in the State of Goiás, Brazil. Methods: We conducted a descriptive cross-sectional study to assess medical records of patients with ALS followed-up at the State Rehabilitation and Readaptation Medical Center Dr. Henrique Santillo, Goiânia, GO, Brazil, between 2005 and 2018. In addition, we registered and created a photographic panel with the main clinical findings of ALS cases. Results: From 224 investigated patients, 51.8% were male, and 67.4% manifested the classic form of the disease. Initial symptoms were more frequent in the lower limbs (37.9%), and complications resulted in 45.5% of tracheostomy, 60.3% of gastrostomy, and 49.1% of deaths. Most patients had a five-year survival from the onset of symptoms, and no significant association between the use of non-invasive ventilation and increased survival were found. The analysis of the clinical-epidemiological characteristics showed a more extended time between the first symptoms and the diagnosis of the disease was observed. Conclusion: In this study, the time between the first symptoms and diagnosis was longer than in the literature, resulting in late treatments. In addition, there was no satisfactory result regarding survival with the use of non-invasive ventilation. Therefore, clinical-epidemiological studies of the disease in Brazil, as well as public awareness and training of professionals in recognition of ALS clinical signs will assist in early and more efficient interventions. https://www.revistas.usp.br/rmrp/article/view/192620Amyotrophic Lateral SclerosisBrazilCross-sectional studyEpidemiologyPhotographic panel |
| spellingShingle | Dhiogo da Cruz Pereira Bento Rayana Pereira Dantas de Oliveira Kamilla de Faria Santos Rômulo Morais Azevedo Lays Bernardes Minasi Yves Mauro Fernandes Ternes Angela Adamski da Silva Reis Rodrigo da Silva Santos Clinical and epidemiological characteristics of patients with Amyotrophic Lateral Sclerosis (ALS) in central Brazil Medicina Amyotrophic Lateral Sclerosis Brazil Cross-sectional study Epidemiology Photographic panel |
| title | Clinical and epidemiological characteristics of patients with Amyotrophic Lateral Sclerosis (ALS) in central Brazil |
| title_full | Clinical and epidemiological characteristics of patients with Amyotrophic Lateral Sclerosis (ALS) in central Brazil |
| title_fullStr | Clinical and epidemiological characteristics of patients with Amyotrophic Lateral Sclerosis (ALS) in central Brazil |
| title_full_unstemmed | Clinical and epidemiological characteristics of patients with Amyotrophic Lateral Sclerosis (ALS) in central Brazil |
| title_short | Clinical and epidemiological characteristics of patients with Amyotrophic Lateral Sclerosis (ALS) in central Brazil |
| title_sort | clinical and epidemiological characteristics of patients with amyotrophic lateral sclerosis als in central brazil |
| topic | Amyotrophic Lateral Sclerosis Brazil Cross-sectional study Epidemiology Photographic panel |
| url | https://www.revistas.usp.br/rmrp/article/view/192620 |
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