Initiating an epilepsy surgery program with limited resources in Indonesia
Abstract To share the experiences of organizing the epilepsy surgery program in Indonesia. This study was divided into two periods based on the presurgical evaluation method: the first period (1999–2004), when interictal electroencephalogram (EEG) and magnetic resonance imaging (MRI) were used mainl...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-84404-5 |
| _version_ | 1818345481339666432 |
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| author | Muhamad Thohar Arifin Ryosuke Hanaya Yuriz Bakhtiar Aris Catur Bintoro Koji Iida Kaoru Kurisu Kazunori Arita Jacob Bunyamin Rofat Askoro Surya Pratama Brilliantika Novita Ikbar Khairunnisa Zainal Muttaqin |
| author_facet | Muhamad Thohar Arifin Ryosuke Hanaya Yuriz Bakhtiar Aris Catur Bintoro Koji Iida Kaoru Kurisu Kazunori Arita Jacob Bunyamin Rofat Askoro Surya Pratama Brilliantika Novita Ikbar Khairunnisa Zainal Muttaqin |
| author_sort | Muhamad Thohar Arifin |
| collection | DOAJ |
| description | Abstract To share the experiences of organizing the epilepsy surgery program in Indonesia. This study was divided into two periods based on the presurgical evaluation method: the first period (1999–2004), when interictal electroencephalogram (EEG) and magnetic resonance imaging (MRI) were used mainly for confirmation, and the second period (2005–2017), when long-term non-invasive and invasive video-EEG was involved in the evaluation. Long-term outcomes were recorded up to December 2019 based on the Engel scale. All 65 surgical recruits in the first period possessed temporal lobe epilepsy (TLE), while 524 patients were treated in the second period. In the first period, 76.8%, 16.1%, and 7.1% of patients with TLE achieved Classes I, II, and III, respectively, and in the second period, 89.4%, 5.5%, and 4.9% achieved Classes I, II, and III, respectively, alongside Class IV, at 0.3%. The overall median survival times for patients with focal impaired awareness seizures (FIAS), focal to bilateral tonic–clonic seizures and generalized tonic–clonic seizures were 9, 11 and 11 years (95% CI: 8.170–9.830, 10.170–11.830, and 7.265–14.735), respectively, with p = 0.04. The utilization of stringent and selective criteria to reserve surgeries is important for a successful epilepsy program with limited resources. |
| first_indexed | 2024-12-13T17:03:03Z |
| format | Article |
| id | doaj.art-4d6ab90344754580a7e1eae8db1ba352 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T17:03:03Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4d6ab90344754580a7e1eae8db1ba3522022-12-21T23:37:45ZengNature PortfolioScientific Reports2045-23222021-03-0111111110.1038/s41598-021-84404-5Initiating an epilepsy surgery program with limited resources in IndonesiaMuhamad Thohar Arifin0Ryosuke Hanaya1Yuriz Bakhtiar2Aris Catur Bintoro3Koji Iida4Kaoru Kurisu5Kazunori Arita6Jacob Bunyamin7Rofat Askoro8Surya Pratama Brilliantika9Novita Ikbar Khairunnisa10Zainal Muttaqin11Department of Neurosurgery, Faculty of Medicine, Diponegoro UniversityDepartment of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima UniversityDepartment of Neurosurgery, Faculty of Medicine, Diponegoro UniversityDepartment of Neurology, Faculty of Medicine, Diponegoro UniversityDepartment of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima UniversityDepartment of Neurosurgery, Faculty of Medicine, Diponegoro UniversityDepartment of Neurosurgery, Faculty of Medicine, Diponegoro UniversityDepartment of Neurosurgery, Faculty of Medicine, Diponegoro UniversityDepartment of Neurosurgery, Faculty of Medicine, Diponegoro UniversityDepartment of Neurosurgery, Faculty of Medicine, Diponegoro UniversityAbstract To share the experiences of organizing the epilepsy surgery program in Indonesia. This study was divided into two periods based on the presurgical evaluation method: the first period (1999–2004), when interictal electroencephalogram (EEG) and magnetic resonance imaging (MRI) were used mainly for confirmation, and the second period (2005–2017), when long-term non-invasive and invasive video-EEG was involved in the evaluation. Long-term outcomes were recorded up to December 2019 based on the Engel scale. All 65 surgical recruits in the first period possessed temporal lobe epilepsy (TLE), while 524 patients were treated in the second period. In the first period, 76.8%, 16.1%, and 7.1% of patients with TLE achieved Classes I, II, and III, respectively, and in the second period, 89.4%, 5.5%, and 4.9% achieved Classes I, II, and III, respectively, alongside Class IV, at 0.3%. The overall median survival times for patients with focal impaired awareness seizures (FIAS), focal to bilateral tonic–clonic seizures and generalized tonic–clonic seizures were 9, 11 and 11 years (95% CI: 8.170–9.830, 10.170–11.830, and 7.265–14.735), respectively, with p = 0.04. The utilization of stringent and selective criteria to reserve surgeries is important for a successful epilepsy program with limited resources.https://doi.org/10.1038/s41598-021-84404-5 |
| spellingShingle | Muhamad Thohar Arifin Ryosuke Hanaya Yuriz Bakhtiar Aris Catur Bintoro Koji Iida Kaoru Kurisu Kazunori Arita Jacob Bunyamin Rofat Askoro Surya Pratama Brilliantika Novita Ikbar Khairunnisa Zainal Muttaqin Initiating an epilepsy surgery program with limited resources in Indonesia Scientific Reports |
| title | Initiating an epilepsy surgery program with limited resources in Indonesia |
| title_full | Initiating an epilepsy surgery program with limited resources in Indonesia |
| title_fullStr | Initiating an epilepsy surgery program with limited resources in Indonesia |
| title_full_unstemmed | Initiating an epilepsy surgery program with limited resources in Indonesia |
| title_short | Initiating an epilepsy surgery program with limited resources in Indonesia |
| title_sort | initiating an epilepsy surgery program with limited resources in indonesia |
| url | https://doi.org/10.1038/s41598-021-84404-5 |
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