Recapitulation and investigation of human brain development with neural organoids
Organoids are 3D cultured tissues derived from stem cells that resemble the structure of living organs. Based on the accumulated knowledge of neural development, neural organoids that recapitulate neural tissue have been created by inducing self-organized neural differentiation of stem cells. Neural...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | IBRO Neuroscience Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242123022935 |
| _version_ | 1797357771301060608 |
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| author | Atsushi Tamada Keiko Muguruma |
| author_facet | Atsushi Tamada Keiko Muguruma |
| author_sort | Atsushi Tamada |
| collection | DOAJ |
| description | Organoids are 3D cultured tissues derived from stem cells that resemble the structure of living organs. Based on the accumulated knowledge of neural development, neural organoids that recapitulate neural tissue have been created by inducing self-organized neural differentiation of stem cells. Neural organoid techniques have been applied to human pluripotent stem cells to differentiate 3D human neural tissues in culture. Various methods have been developed to generate neural tissues of different regions. Currently, neural organoid technology has several significant limitations, which are being overcome in an attempt to create neural organoids that more faithfully recapitulate the living brain. The rapidly advancing neural organoid technology enables the use of living human neural tissue as research material and contributes to our understanding of the development, structure and function of the human nervous system, and is expected to be used to overcome neurological diseases and for regenerative medicine. |
| first_indexed | 2024-03-08T14:48:52Z |
| format | Article |
| id | doaj.art-4d6b78eb441c4dc4a23f7a0365279e50 |
| institution | Directory Open Access Journal |
| issn | 2667-2421 |
| language | English |
| last_indexed | 2024-03-08T14:48:52Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj.art-4d6b78eb441c4dc4a23f7a0365279e502024-01-11T04:32:02ZengElsevierIBRO Neuroscience Reports2667-24212024-06-0116106117Recapitulation and investigation of human brain development with neural organoidsAtsushi Tamada0Keiko Muguruma1Department of iPS Cell Applied Medicine, Faculty of Medicine, Kansai Medical University, Hirakata, Osaka 573-1010, JapanCorresponding author.; Department of iPS Cell Applied Medicine, Faculty of Medicine, Kansai Medical University, Hirakata, Osaka 573-1010, JapanOrganoids are 3D cultured tissues derived from stem cells that resemble the structure of living organs. Based on the accumulated knowledge of neural development, neural organoids that recapitulate neural tissue have been created by inducing self-organized neural differentiation of stem cells. Neural organoid techniques have been applied to human pluripotent stem cells to differentiate 3D human neural tissues in culture. Various methods have been developed to generate neural tissues of different regions. Currently, neural organoid technology has several significant limitations, which are being overcome in an attempt to create neural organoids that more faithfully recapitulate the living brain. The rapidly advancing neural organoid technology enables the use of living human neural tissue as research material and contributes to our understanding of the development, structure and function of the human nervous system, and is expected to be used to overcome neurological diseases and for regenerative medicine.http://www.sciencedirect.com/science/article/pii/S2667242123022935Neural organoidPluripotent stem cells3D cultureSelf-organizationNeural inductionRegional patterning |
| spellingShingle | Atsushi Tamada Keiko Muguruma Recapitulation and investigation of human brain development with neural organoids IBRO Neuroscience Reports Neural organoid Pluripotent stem cells 3D culture Self-organization Neural induction Regional patterning |
| title | Recapitulation and investigation of human brain development with neural organoids |
| title_full | Recapitulation and investigation of human brain development with neural organoids |
| title_fullStr | Recapitulation and investigation of human brain development with neural organoids |
| title_full_unstemmed | Recapitulation and investigation of human brain development with neural organoids |
| title_short | Recapitulation and investigation of human brain development with neural organoids |
| title_sort | recapitulation and investigation of human brain development with neural organoids |
| topic | Neural organoid Pluripotent stem cells 3D culture Self-organization Neural induction Regional patterning |
| url | http://www.sciencedirect.com/science/article/pii/S2667242123022935 |
| work_keys_str_mv | AT atsushitamada recapitulationandinvestigationofhumanbraindevelopmentwithneuralorganoids AT keikomuguruma recapitulationandinvestigationofhumanbraindevelopmentwithneuralorganoids |