PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers

PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers

Abstract Glioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI protein...

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Bibliographic Details
Main Authors: Omid Reza Tamtaji, Mohammad Behnam, Mohammad Ali Pourattar, Michael R. Hamblin, Maryam Mahjoubin-Tehran, Hamed Mirzaei, Zatollah Asemi
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Cell Communication and Signaling
Subjects:
piRNAs
PIWI protein
Glioma
Apoptosis
Migration
Invasion
Online Access:http://link.springer.com/article/10.1186/s12964-020-00657-z
Description
Summary:Abstract Glioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI proteins are involved in tumorigenesis by epigenetic mechanisms. Hence, it seems that piRNAs and PIWI proteins may be potential prognostic, diagnostic or therapeutic biomarkers in the treatment of glioma. Previous studies have demonstrated a relationship between piRNAs and PIWI proteins and some of the molecular and cellular pathways in glioma. Here, we summarize recent evidence and evaluate the molecular mechanisms by which piRNAs and PIWI proteins are involved in glioma. Video abstract
ISSN:1478-811X

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