PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers
Abstract Glioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI protein...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12964-020-00657-z |
| _version_ | 1818140056752226304 |
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| author | Omid Reza Tamtaji Mohammad Behnam Mohammad Ali Pourattar Michael R. Hamblin Maryam Mahjoubin-Tehran Hamed Mirzaei Zatollah Asemi |
| author_facet | Omid Reza Tamtaji Mohammad Behnam Mohammad Ali Pourattar Michael R. Hamblin Maryam Mahjoubin-Tehran Hamed Mirzaei Zatollah Asemi |
| author_sort | Omid Reza Tamtaji |
| collection | DOAJ |
| description | Abstract Glioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI proteins are involved in tumorigenesis by epigenetic mechanisms. Hence, it seems that piRNAs and PIWI proteins may be potential prognostic, diagnostic or therapeutic biomarkers in the treatment of glioma. Previous studies have demonstrated a relationship between piRNAs and PIWI proteins and some of the molecular and cellular pathways in glioma. Here, we summarize recent evidence and evaluate the molecular mechanisms by which piRNAs and PIWI proteins are involved in glioma. Video abstract |
| first_indexed | 2024-12-11T10:37:55Z |
| format | Article |
| id | doaj.art-4d6c0ab1cb7a4aefbfc91613d93ec954 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-12-11T10:37:55Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-4d6c0ab1cb7a4aefbfc91613d93ec9542022-12-22T01:10:40ZengBMCCell Communication and Signaling1478-811X2020-10-0118111110.1186/s12964-020-00657-zPIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkersOmid Reza Tamtaji0Mohammad Behnam1Mohammad Ali Pourattar2Michael R. Hamblin3Maryam Mahjoubin-Tehran4Hamed Mirzaei5Zatollah Asemi6Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical SciencesHalal Research Center of IRI, FDADepartment of Radiobiology, Iran University of Medical SciencesLaser Research Centre, Faculty of Health Science, University of JohannesburgStudent Research Committee, Mashhad University of Medical SciencesResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical SciencesResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical SciencesAbstract Glioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI proteins are involved in tumorigenesis by epigenetic mechanisms. Hence, it seems that piRNAs and PIWI proteins may be potential prognostic, diagnostic or therapeutic biomarkers in the treatment of glioma. Previous studies have demonstrated a relationship between piRNAs and PIWI proteins and some of the molecular and cellular pathways in glioma. Here, we summarize recent evidence and evaluate the molecular mechanisms by which piRNAs and PIWI proteins are involved in glioma. Video abstracthttp://link.springer.com/article/10.1186/s12964-020-00657-zpiRNAsPIWI proteinGliomaApoptosisMigrationInvasion |
| spellingShingle | Omid Reza Tamtaji Mohammad Behnam Mohammad Ali Pourattar Michael R. Hamblin Maryam Mahjoubin-Tehran Hamed Mirzaei Zatollah Asemi PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers Cell Communication and Signaling piRNAs PIWI protein Glioma Apoptosis Migration Invasion |
| title | PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers |
| title_full | PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers |
| title_fullStr | PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers |
| title_full_unstemmed | PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers |
| title_short | PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers |
| title_sort | piwi interacting rnas and piwi proteins in glioma molecular pathogenesis and role as biomarkers |
| topic | piRNAs PIWI protein Glioma Apoptosis Migration Invasion |
| url | http://link.springer.com/article/10.1186/s12964-020-00657-z |
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