Estimation of Photon Specific Absorbed Fractions in Digimouse Voxel Phantom using Monte Carlo Simulation Code FLUKA
Background: Most preclinical studies are carried out on mice. For internal dose assessment of a mouse, specific absorbed fraction (SAF) values play an important role. In most studies, SAF values are estimated using older standard human organ compositions and values for limited source target pairs...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2016-12-01
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| Series: | Journal of Biomedical Physics and Engineering |
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| Online Access: | http://www.jbpe.org/Journal_OJS/JBPE/index.php/jbpe/article/view/393/231 |
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| author | Sinha A Patni H. K Dixit B. M. Painuly N. K Singh N. |
| author_facet | Sinha A Patni H. K Dixit B. M. Painuly N. K Singh N. |
| author_sort | Sinha A |
| collection | DOAJ |
| description | Background: Most preclinical studies are carried out on mice. For internal dose
assessment of a mouse, specific absorbed fraction (SAF) values play an important role.
In most studies, SAF values are estimated using older standard human organ compositions
and values for limited source target pairs.
Objective: SAF values for monoenergetic photons of energies 15, 50, 100, 500,
1000 and 4000 keV were evaluated for the Digimouse voxel phantom incorporated in
Monte Carlo code FLUKA. The organ sources considered in this study were lungs,
skeleton, heart, bladder, testis, stomach, spleen, pancreas, liver, kidney, adrenal, eye
and brain. The considered target organs were lungs, skeleton, heart, bladder, testis,
stomach, spleen, pancreas, liver, kidney, adrenal and brain. Eye was considered as a
target organ only for eye as a source organ. Organ compositions and densities were
adopted from International Commission on Radiological Protection (ICRP) publication
number 110.
Results: Evaluated organ masses and SAF values are presented in tabular form.
It is observed that SAF values decrease with increasing the source-to-target distance.
The SAF value for self-irradiation decreases with increasing photon energy. The SAF
values are also found to be dependent on the mass of target in such a way that higher
values are obtained for lower masses. The effect of composition is highest in case of
target organ lungs where mass and estimated SAF values are found to have larger differences.
Conclusion: These SAF values are very important for absorbed dose calculation
for various organs of a mouse |
| first_indexed | 2024-12-14T05:15:02Z |
| format | Article |
| id | doaj.art-4d6d9a187f2643b69fde275d3e351f36 |
| institution | Directory Open Access Journal |
| issn | 2251-7200 2251-7200 |
| language | English |
| last_indexed | 2024-12-14T05:15:02Z |
| publishDate | 2016-12-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Journal of Biomedical Physics and Engineering |
| spelling | doaj.art-4d6d9a187f2643b69fde275d3e351f362022-12-21T23:15:51ZengShiraz University of Medical SciencesJournal of Biomedical Physics and Engineering2251-72002251-72002016-12-01642092016Estimation of Photon Specific Absorbed Fractions in Digimouse Voxel Phantom using Monte Carlo Simulation Code FLUKASinha A0 Patni H. K1Dixit B. M.2Painuly N. K3 Singh N.4Faculty of Physical Sciences, Shri Ramswaroop Memorial University, Lucknow, IndiaBhabha Atomic Research Center, Mumbai, IndiaFaculty of Physical Sciences, Shri Ramswaroop Memorial University, Lucknow, IndiaDepartment of Radiotherapy, King George Medical University, Lucknow, IndiaDepartment of Radiotherapy, King George Medical University, Lucknow, IndiaBackground: Most preclinical studies are carried out on mice. For internal dose assessment of a mouse, specific absorbed fraction (SAF) values play an important role. In most studies, SAF values are estimated using older standard human organ compositions and values for limited source target pairs. Objective: SAF values for monoenergetic photons of energies 15, 50, 100, 500, 1000 and 4000 keV were evaluated for the Digimouse voxel phantom incorporated in Monte Carlo code FLUKA. The organ sources considered in this study were lungs, skeleton, heart, bladder, testis, stomach, spleen, pancreas, liver, kidney, adrenal, eye and brain. The considered target organs were lungs, skeleton, heart, bladder, testis, stomach, spleen, pancreas, liver, kidney, adrenal and brain. Eye was considered as a target organ only for eye as a source organ. Organ compositions and densities were adopted from International Commission on Radiological Protection (ICRP) publication number 110. Results: Evaluated organ masses and SAF values are presented in tabular form. It is observed that SAF values decrease with increasing the source-to-target distance. The SAF value for self-irradiation decreases with increasing photon energy. The SAF values are also found to be dependent on the mass of target in such a way that higher values are obtained for lower masses. The effect of composition is highest in case of target organ lungs where mass and estimated SAF values are found to have larger differences. Conclusion: These SAF values are very important for absorbed dose calculation for various organs of a mousehttp://www.jbpe.org/Journal_OJS/JBPE/index.php/jbpe/article/view/393/231Specific Absorbed FractionDigimouse Voxel PhantomMonte Carlo Simulation |
| spellingShingle | Sinha A Patni H. K Dixit B. M. Painuly N. K Singh N. Estimation of Photon Specific Absorbed Fractions in Digimouse Voxel Phantom using Monte Carlo Simulation Code FLUKA Journal of Biomedical Physics and Engineering Specific Absorbed Fraction Digimouse Voxel Phantom Monte Carlo Simulation |
| title | Estimation of Photon Specific Absorbed Fractions in Digimouse Voxel Phantom using Monte Carlo Simulation Code FLUKA |
| title_full | Estimation of Photon Specific Absorbed Fractions in Digimouse Voxel Phantom using Monte Carlo Simulation Code FLUKA |
| title_fullStr | Estimation of Photon Specific Absorbed Fractions in Digimouse Voxel Phantom using Monte Carlo Simulation Code FLUKA |
| title_full_unstemmed | Estimation of Photon Specific Absorbed Fractions in Digimouse Voxel Phantom using Monte Carlo Simulation Code FLUKA |
| title_short | Estimation of Photon Specific Absorbed Fractions in Digimouse Voxel Phantom using Monte Carlo Simulation Code FLUKA |
| title_sort | estimation of photon specific absorbed fractions in digimouse voxel phantom using monte carlo simulation code fluka |
| topic | Specific Absorbed Fraction Digimouse Voxel Phantom Monte Carlo Simulation |
| url | http://www.jbpe.org/Journal_OJS/JBPE/index.php/jbpe/article/view/393/231 |
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