A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems
Over the last years of research on drug delivery systems (DDSs), natural polymer-based hydrogels have shown many scientific advances due to their intrinsic properties and a wide variety of potential applications. While drug efficacy and cytotoxicity play a key role, adopting a proper DDS is crucial...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/24/5432 |
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| author | Bahareh Farasati Far Mohammad Reza Naimi-Jamal Maryam Safaei Kimia Zarei Marzieh Moradi Hamed Yazdani Nezhad |
| author_facet | Bahareh Farasati Far Mohammad Reza Naimi-Jamal Maryam Safaei Kimia Zarei Marzieh Moradi Hamed Yazdani Nezhad |
| author_sort | Bahareh Farasati Far |
| collection | DOAJ |
| description | Over the last years of research on drug delivery systems (DDSs), natural polymer-based hydrogels have shown many scientific advances due to their intrinsic properties and a wide variety of potential applications. While drug efficacy and cytotoxicity play a key role, adopting a proper DDS is crucial to preserve the drug along the route of administration and possess desired therapeutic effect at the targeted site. Thus, drug delivery technology can be used to overcome the difficulties of maintaining drugs at a physiologically related serum concentration for prolonged periods. Due to their outstanding biocompatibility, polysaccharides have been thoroughly researched as a biological material for DDS advancement. To formulate a modified DDS, polysaccharides can cross-link with different molecules, resulting in hydrogels. According to our recent findings, targeted drug delivery at a certain spot occurs due to external stimulation such as temperature, pH, glucose, or light. As an adjustable biomedical device, the hydrogel has tremendous potential for nanotech applications in involved health areas such as pharmaceutical and biomedical engineering. An overview of hydrogel characteristics and functionalities is provided in this review. We focus on discussing the various kinds of hydrogel-based systems on their potential for effectively delivering drugs that are made of polysaccharides. |
| first_indexed | 2024-03-09T15:56:22Z |
| format | Article |
| id | doaj.art-4d6df072dc124af29af50763e32a0e58 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T15:56:22Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-4d6df072dc124af29af50763e32a0e582023-11-24T17:32:01ZengMDPI AGPolymers2073-43602022-12-011424543210.3390/polym14245432A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery SystemsBahareh Farasati Far0Mohammad Reza Naimi-Jamal1Maryam Safaei2Kimia Zarei3Marzieh Moradi4Hamed Yazdani Nezhad5Research Laboratory of Green Organic Synthesis and Polymers, Department of Chemistry, Iran University of Science and Technology, Tehran 1684613114, IranResearch Laboratory of Green Organic Synthesis and Polymers, Department of Chemistry, Iran University of Science and Technology, Tehran 1684613114, IranDepartment of Pharmacology, Faculty of Pharmacy, Eastern Mediterranean University, Famagusta 99628, TurkeyFaculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran 1916893813, IranFaculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, IranDepartment of Mechanical Engineering & Aeronautics, City University of London, London EC1V 0HB, UKOver the last years of research on drug delivery systems (DDSs), natural polymer-based hydrogels have shown many scientific advances due to their intrinsic properties and a wide variety of potential applications. While drug efficacy and cytotoxicity play a key role, adopting a proper DDS is crucial to preserve the drug along the route of administration and possess desired therapeutic effect at the targeted site. Thus, drug delivery technology can be used to overcome the difficulties of maintaining drugs at a physiologically related serum concentration for prolonged periods. Due to their outstanding biocompatibility, polysaccharides have been thoroughly researched as a biological material for DDS advancement. To formulate a modified DDS, polysaccharides can cross-link with different molecules, resulting in hydrogels. According to our recent findings, targeted drug delivery at a certain spot occurs due to external stimulation such as temperature, pH, glucose, or light. As an adjustable biomedical device, the hydrogel has tremendous potential for nanotech applications in involved health areas such as pharmaceutical and biomedical engineering. An overview of hydrogel characteristics and functionalities is provided in this review. We focus on discussing the various kinds of hydrogel-based systems on their potential for effectively delivering drugs that are made of polysaccharides.https://www.mdpi.com/2073-4360/14/24/5432polysaccharidedrug deliveryhydrogelbioengineeringbiomedical application |
| spellingShingle | Bahareh Farasati Far Mohammad Reza Naimi-Jamal Maryam Safaei Kimia Zarei Marzieh Moradi Hamed Yazdani Nezhad A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems Polymers polysaccharide drug delivery hydrogel bioengineering biomedical application |
| title | A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems |
| title_full | A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems |
| title_fullStr | A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems |
| title_full_unstemmed | A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems |
| title_short | A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems |
| title_sort | review on biomedical application of polysaccharide based hydrogels with a focus on drug delivery systems |
| topic | polysaccharide drug delivery hydrogel bioengineering biomedical application |
| url | https://www.mdpi.com/2073-4360/14/24/5432 |
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