The Potentials of Methylene Blue as an Anti-Aging Drug
Methylene blue (MB), as the first fully man-made medicine, has a wide range of clinical applications. Apart from its well-known applications in surgical staining, malaria, and methemoglobinemia, the anti-oxidative properties of MB recently brought new attention to this century-old drug. Mitochondria...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/12/3379 |
| _version_ | 1797505950371807232 |
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| author | Huijing Xue Abhirami Thaivalappil Kan Cao |
| author_facet | Huijing Xue Abhirami Thaivalappil Kan Cao |
| author_sort | Huijing Xue |
| collection | DOAJ |
| description | Methylene blue (MB), as the first fully man-made medicine, has a wide range of clinical applications. Apart from its well-known applications in surgical staining, malaria, and methemoglobinemia, the anti-oxidative properties of MB recently brought new attention to this century-old drug. Mitochondrial dysfunction has been observed in systematic aging that affects many different tissues, including the brain and skin. This leads to increaseding oxidative stress and results in downstream phenotypes under age-related conditions. MB can bypass Complex I/III activity in mitochondria and diminish oxidative stress to some degree. This review summarizes the recent studies on the applications of MB in treating age-related conditions, including neurodegeneration, memory loss, skin aging, and a premature aging disease, progeria. |
| first_indexed | 2024-03-10T04:25:39Z |
| format | Article |
| id | doaj.art-4d6e85c84d834ddd81e5708cc9c566ff |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T04:25:39Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-4d6e85c84d834ddd81e5708cc9c566ff2023-11-23T07:36:58ZengMDPI AGCells2073-44092021-12-011012337910.3390/cells10123379The Potentials of Methylene Blue as an Anti-Aging DrugHuijing Xue0Abhirami Thaivalappil1Kan Cao2Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USADepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USADepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USAMethylene blue (MB), as the first fully man-made medicine, has a wide range of clinical applications. Apart from its well-known applications in surgical staining, malaria, and methemoglobinemia, the anti-oxidative properties of MB recently brought new attention to this century-old drug. Mitochondrial dysfunction has been observed in systematic aging that affects many different tissues, including the brain and skin. This leads to increaseding oxidative stress and results in downstream phenotypes under age-related conditions. MB can bypass Complex I/III activity in mitochondria and diminish oxidative stress to some degree. This review summarizes the recent studies on the applications of MB in treating age-related conditions, including neurodegeneration, memory loss, skin aging, and a premature aging disease, progeria.https://www.mdpi.com/2073-4409/10/12/3379methylene bluemitochondrianeurodegenerationskin agingprogeria |
| spellingShingle | Huijing Xue Abhirami Thaivalappil Kan Cao The Potentials of Methylene Blue as an Anti-Aging Drug Cells methylene blue mitochondria neurodegeneration skin aging progeria |
| title | The Potentials of Methylene Blue as an Anti-Aging Drug |
| title_full | The Potentials of Methylene Blue as an Anti-Aging Drug |
| title_fullStr | The Potentials of Methylene Blue as an Anti-Aging Drug |
| title_full_unstemmed | The Potentials of Methylene Blue as an Anti-Aging Drug |
| title_short | The Potentials of Methylene Blue as an Anti-Aging Drug |
| title_sort | potentials of methylene blue as an anti aging drug |
| topic | methylene blue mitochondria neurodegeneration skin aging progeria |
| url | https://www.mdpi.com/2073-4409/10/12/3379 |
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