Local endovascular infusion and hypothermia in stroke therapy: A systematic review
Ischemic stroke is a leading cause of death and disability worldwide, but there are no effective, widely applicable stroke therapies. Systemic hypothermia is an international mainstay of postcardiac arrest care, and the neuroprotective benefits of systemic hypothermia following cerebral ischemia hav...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Brain Circulation |
| Subjects: | |
| Online Access: | http://www.braincirculation.org/article.asp?issn=2394-8108;year=2019;volume=5;issue=2;spage=68;epage=73;aulast=Duan |
| _version_ | 1818943598688731136 |
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| author | Honglian Duan Mitchell Huber Jessie N Ding Christian Huber Xiaokun Geng |
| author_facet | Honglian Duan Mitchell Huber Jessie N Ding Christian Huber Xiaokun Geng |
| author_sort | Honglian Duan |
| collection | DOAJ |
| description | Ischemic stroke is a leading cause of death and disability worldwide, but there are no effective, widely applicable stroke therapies. Systemic hypothermia is an international mainstay of postcardiac arrest care, and the neuroprotective benefits of systemic hypothermia following cerebral ischemia have been proven in clinical trials, but logistical issues hinder clinical acceptance. As a novel solution to these logistical issues, the application of local endovascular infusion of cold saline directly to the infarct site using a microcatheter has been put forth. In small animal models, the procedure has shown incredible neuroprotective promise on the biochemical, structural, and functional levels, and preliminary trials in large animals and humans have been similarly encouraging. In addition, the procedure would be relatively cost-effective and widely applicable. The administration of local endovascular hypothermia in humans is relatively simple, as this is a normal part of endovascular intervention for neuroendovascular surgeons. Therefore, it is expected that this new therapy could easily be added to an angiography suite. However, the neuroprotective efficacy in humans has yet to be determined, which is an end goal of researchers in the field. Given the potentially massive benefits, ease of induction, and cost-effective nature, it is likely that local endovascular hypothermia will become an integral part of endovascular treatment following ischemic stroke. This review outlines relevant research, discusses neuroprotective mechanisms, and discusses possibilities for future directions. |
| first_indexed | 2024-12-20T07:29:53Z |
| format | Article |
| id | doaj.art-4d6f5a4805364b3fbad5addd19298af0 |
| institution | Directory Open Access Journal |
| issn | 2455-4626 |
| language | English |
| last_indexed | 2024-12-20T07:29:53Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Brain Circulation |
| spelling | doaj.art-4d6f5a4805364b3fbad5addd19298af02022-12-21T19:48:27ZengWolters Kluwer Medknow PublicationsBrain Circulation2455-46262019-01-0152687310.4103/bc.bc_9_19Local endovascular infusion and hypothermia in stroke therapy: A systematic reviewHonglian DuanMitchell HuberJessie N DingChristian HuberXiaokun GengIschemic stroke is a leading cause of death and disability worldwide, but there are no effective, widely applicable stroke therapies. Systemic hypothermia is an international mainstay of postcardiac arrest care, and the neuroprotective benefits of systemic hypothermia following cerebral ischemia have been proven in clinical trials, but logistical issues hinder clinical acceptance. As a novel solution to these logistical issues, the application of local endovascular infusion of cold saline directly to the infarct site using a microcatheter has been put forth. In small animal models, the procedure has shown incredible neuroprotective promise on the biochemical, structural, and functional levels, and preliminary trials in large animals and humans have been similarly encouraging. In addition, the procedure would be relatively cost-effective and widely applicable. The administration of local endovascular hypothermia in humans is relatively simple, as this is a normal part of endovascular intervention for neuroendovascular surgeons. Therefore, it is expected that this new therapy could easily be added to an angiography suite. However, the neuroprotective efficacy in humans has yet to be determined, which is an end goal of researchers in the field. Given the potentially massive benefits, ease of induction, and cost-effective nature, it is likely that local endovascular hypothermia will become an integral part of endovascular treatment following ischemic stroke. This review outlines relevant research, discusses neuroprotective mechanisms, and discusses possibilities for future directions.http://www.braincirculation.org/article.asp?issn=2394-8108;year=2019;volume=5;issue=2;spage=68;epage=73;aulast=Duanendovascular stroke therapylocal endovascular infusionlocal hypothermia |
| spellingShingle | Honglian Duan Mitchell Huber Jessie N Ding Christian Huber Xiaokun Geng Local endovascular infusion and hypothermia in stroke therapy: A systematic review Brain Circulation endovascular stroke therapy local endovascular infusion local hypothermia |
| title | Local endovascular infusion and hypothermia in stroke therapy: A systematic review |
| title_full | Local endovascular infusion and hypothermia in stroke therapy: A systematic review |
| title_fullStr | Local endovascular infusion and hypothermia in stroke therapy: A systematic review |
| title_full_unstemmed | Local endovascular infusion and hypothermia in stroke therapy: A systematic review |
| title_short | Local endovascular infusion and hypothermia in stroke therapy: A systematic review |
| title_sort | local endovascular infusion and hypothermia in stroke therapy a systematic review |
| topic | endovascular stroke therapy local endovascular infusion local hypothermia |
| url | http://www.braincirculation.org/article.asp?issn=2394-8108;year=2019;volume=5;issue=2;spage=68;epage=73;aulast=Duan |
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