Photophysical isomerization of liposomal bilayer-included caffeic acid phenethyl ester leading to membrane dehydration
Caffeic acid phenethyl ester (CAPE) is well known for its prolific biological and pharmaceutical applications. There are plethora of studies on CAPE in context to antimicrobial, antiviral, anti-inflammatory and anticancer activities. It has been applied even to suppress chemotherapy-induced toxiciti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Chemical Physics Impact |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667022423000725 |
| _version_ | 1797800905802776576 |
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| author | Ankit Kumar Sharma Arunavo Chatterjee Pradipta Purkayastha |
| author_facet | Ankit Kumar Sharma Arunavo Chatterjee Pradipta Purkayastha |
| author_sort | Ankit Kumar Sharma |
| collection | DOAJ |
| description | Caffeic acid phenethyl ester (CAPE) is well known for its prolific biological and pharmaceutical applications. There are plethora of studies on CAPE in context to antimicrobial, antiviral, anti-inflammatory and anticancer activities. It has been applied even to suppress chemotherapy-induced toxicities. However, an important property of CAPE has been so far overlooked, which is its photoinduced cis/trans isomerization. The present study has enlightened upon the detailed photophysical changes and the related physical parameters in CAPE. CAPE, being a membrane binding molecule, has been added to the hydrophobic portion of the bilayer of large unilamelar vesicles (LUVs) made from dimyristoyltrimethylammonium propane (DMTAP) lipids in aqueous buffer (pH 7.4). Absorption of light and conversion of the trans-isomers to the cis-form led to vesicular squeezing followed by expulsion of the penetrated water molecules that hydrated the liposomal membrane. |
| first_indexed | 2024-03-13T04:42:52Z |
| format | Article |
| id | doaj.art-4d72f050662d4b68bda1ccfd069be14b |
| institution | Directory Open Access Journal |
| issn | 2667-0224 |
| language | English |
| last_indexed | 2024-03-13T04:42:52Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Chemical Physics Impact |
| spelling | doaj.art-4d72f050662d4b68bda1ccfd069be14b2023-06-19T04:30:23ZengElsevierChemical Physics Impact2667-02242023-06-016100232Photophysical isomerization of liposomal bilayer-included caffeic acid phenethyl ester leading to membrane dehydrationAnkit Kumar Sharma0Arunavo Chatterjee1Pradipta Purkayastha2Department of Chemical Sciences and Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, WB, IndiaDepartment of Chemical Sciences and Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, WB, IndiaCorresponding author.; Department of Chemical Sciences and Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, WB, IndiaCaffeic acid phenethyl ester (CAPE) is well known for its prolific biological and pharmaceutical applications. There are plethora of studies on CAPE in context to antimicrobial, antiviral, anti-inflammatory and anticancer activities. It has been applied even to suppress chemotherapy-induced toxicities. However, an important property of CAPE has been so far overlooked, which is its photoinduced cis/trans isomerization. The present study has enlightened upon the detailed photophysical changes and the related physical parameters in CAPE. CAPE, being a membrane binding molecule, has been added to the hydrophobic portion of the bilayer of large unilamelar vesicles (LUVs) made from dimyristoyltrimethylammonium propane (DMTAP) lipids in aqueous buffer (pH 7.4). Absorption of light and conversion of the trans-isomers to the cis-form led to vesicular squeezing followed by expulsion of the penetrated water molecules that hydrated the liposomal membrane.http://www.sciencedirect.com/science/article/pii/S2667022423000725LiposomesBilayerThicknessCaffeic acidIsomerizationDehydration |
| spellingShingle | Ankit Kumar Sharma Arunavo Chatterjee Pradipta Purkayastha Photophysical isomerization of liposomal bilayer-included caffeic acid phenethyl ester leading to membrane dehydration Chemical Physics Impact Liposomes Bilayer Thickness Caffeic acid Isomerization Dehydration |
| title | Photophysical isomerization of liposomal bilayer-included caffeic acid phenethyl ester leading to membrane dehydration |
| title_full | Photophysical isomerization of liposomal bilayer-included caffeic acid phenethyl ester leading to membrane dehydration |
| title_fullStr | Photophysical isomerization of liposomal bilayer-included caffeic acid phenethyl ester leading to membrane dehydration |
| title_full_unstemmed | Photophysical isomerization of liposomal bilayer-included caffeic acid phenethyl ester leading to membrane dehydration |
| title_short | Photophysical isomerization of liposomal bilayer-included caffeic acid phenethyl ester leading to membrane dehydration |
| title_sort | photophysical isomerization of liposomal bilayer included caffeic acid phenethyl ester leading to membrane dehydration |
| topic | Liposomes Bilayer Thickness Caffeic acid Isomerization Dehydration |
| url | http://www.sciencedirect.com/science/article/pii/S2667022423000725 |
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