Polygonatum sibiricum improves menopause symptoms by regulating hormone receptor balance in an ovariectomized mouse model
Female menopause is a hormone deficiency phenomenon that causes hot flashes, vaginal dryness, depression, nervous tension, insomnia, obesity, and bone loss. There are various hormone replacement therapy (HRT)-based menopausal treatments, but they are accompanied by side effects such as endometrial c...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222007740 |
| _version_ | 1811337766480379904 |
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| author | Doo Ri Park Chang Hwan Yeo Jee Eun Yoon Eun Young Hong Bo Ram Choi Yoon Jae Lee In-Hyuk Ha |
| author_facet | Doo Ri Park Chang Hwan Yeo Jee Eun Yoon Eun Young Hong Bo Ram Choi Yoon Jae Lee In-Hyuk Ha |
| author_sort | Doo Ri Park |
| collection | DOAJ |
| description | Female menopause is a hormone deficiency phenomenon that causes hot flashes, vaginal dryness, depression, nervous tension, insomnia, obesity, and bone loss. There are various hormone replacement therapy (HRT)-based menopausal treatments, but they are accompanied by side effects such as endometrial cancer and hyperplasia. To confirm the menopausal improvement effect of Polygonatum sibiricum (PS), we prepared an ovariectomized animal model, administered 17β-estradiol (E2) and PS, and analyzed various menopausal symptoms. PS restored vaginal epithelium thickness, by increasing the expression of estrogen receptors ERα (ESR1) and ERβ (ESR2), and increased serotonin concentration by reducing serotonin receptor 1 A (5-HT1A) and glucocorticoid receptor (Gr) expression. In addition, PS suppressed obesity by increasing HDL-C and decreasing LDL-C levels and improved the osteoporosis induced by ovariectomy. In particular, by controlling Hand2, Fgf2, and Faf9 expression through PR, the antiproliferative signal was suppressed in uterine epithelium, thereby reducing the risk of side effects of the administration of E2 alone. These results demonstrate that PS alleviates menopausal symptoms without causing endometrial hyperplasia. |
| first_indexed | 2024-04-13T17:59:45Z |
| format | Article |
| id | doaj.art-4d7328be79e447f3a3af3f0b56585685 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-13T17:59:45Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-4d7328be79e447f3a3af3f0b565856852022-12-22T02:36:17ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-09-01153113385Polygonatum sibiricum improves menopause symptoms by regulating hormone receptor balance in an ovariectomized mouse modelDoo Ri Park0Chang Hwan Yeo1Jee Eun Yoon2Eun Young Hong3Bo Ram Choi4Yoon Jae Lee5In-Hyuk Ha6Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, South KoreaJaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, South KoreaJaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, South KoreaJaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, South KoreaJaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, South KoreaJaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, South KoreaCorresponding author.; Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, South KoreaFemale menopause is a hormone deficiency phenomenon that causes hot flashes, vaginal dryness, depression, nervous tension, insomnia, obesity, and bone loss. There are various hormone replacement therapy (HRT)-based menopausal treatments, but they are accompanied by side effects such as endometrial cancer and hyperplasia. To confirm the menopausal improvement effect of Polygonatum sibiricum (PS), we prepared an ovariectomized animal model, administered 17β-estradiol (E2) and PS, and analyzed various menopausal symptoms. PS restored vaginal epithelium thickness, by increasing the expression of estrogen receptors ERα (ESR1) and ERβ (ESR2), and increased serotonin concentration by reducing serotonin receptor 1 A (5-HT1A) and glucocorticoid receptor (Gr) expression. In addition, PS suppressed obesity by increasing HDL-C and decreasing LDL-C levels and improved the osteoporosis induced by ovariectomy. In particular, by controlling Hand2, Fgf2, and Faf9 expression through PR, the antiproliferative signal was suppressed in uterine epithelium, thereby reducing the risk of side effects of the administration of E2 alone. These results demonstrate that PS alleviates menopausal symptoms without causing endometrial hyperplasia.http://www.sciencedirect.com/science/article/pii/S0753332222007740MenopauseEndometrial cancerEndometrial hyperplasiaProgesterone receptorPolygonatum sibiricumHerbal medicine |
| spellingShingle | Doo Ri Park Chang Hwan Yeo Jee Eun Yoon Eun Young Hong Bo Ram Choi Yoon Jae Lee In-Hyuk Ha Polygonatum sibiricum improves menopause symptoms by regulating hormone receptor balance in an ovariectomized mouse model Biomedicine & Pharmacotherapy Menopause Endometrial cancer Endometrial hyperplasia Progesterone receptor Polygonatum sibiricum Herbal medicine |
| title | Polygonatum sibiricum improves menopause symptoms by regulating hormone receptor balance in an ovariectomized mouse model |
| title_full | Polygonatum sibiricum improves menopause symptoms by regulating hormone receptor balance in an ovariectomized mouse model |
| title_fullStr | Polygonatum sibiricum improves menopause symptoms by regulating hormone receptor balance in an ovariectomized mouse model |
| title_full_unstemmed | Polygonatum sibiricum improves menopause symptoms by regulating hormone receptor balance in an ovariectomized mouse model |
| title_short | Polygonatum sibiricum improves menopause symptoms by regulating hormone receptor balance in an ovariectomized mouse model |
| title_sort | polygonatum sibiricum improves menopause symptoms by regulating hormone receptor balance in an ovariectomized mouse model |
| topic | Menopause Endometrial cancer Endometrial hyperplasia Progesterone receptor Polygonatum sibiricum Herbal medicine |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222007740 |
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