Systemic Administration of Avian Defensin 7: Distribution, Cellular Target, and Antibacterial Potential in Mice

Systemic Administration of Avian Defensin 7: Distribution, Cellular Target, and Antibacterial Potential in Mice

Defensins are natural antimicrobial peptides. The avian beta-defensin AvBD7 isolated from the chicken bone marrow possess broad antibacterial spectrum and strong resistance to proteolysis. However, its ability to fight systemic infections of major concern for public health, such as salmonellosis, is...

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Bibliographic Details
Main Authors: Geoffrey Bailleul, Rodrigo Guabiraba, Isabelle Virlogeux-Payant, Isabelle Lantier, Jérôme Trotereau, Florence B. Gilbert, Agnès Wiedemann, Angélina Trotereau, Philippe Velge, Catherine Schouler, Anne-Christine Lalmanach
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Microbiology
Subjects:
chicken
defensins
mouse
macrophages
Salmonella Typhimurium
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00541/full

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