Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced esophageal squamous cell carcinoma
Abstract Background The purpose of this study was to perform a dosimetric comparison between proton beam therapy (PBT) and photon radiation therapy in patients with locally advanced esophageal squamous cell carcinoma (ESCC) who were treated with PBT in our institution. In addition, we evaluated the...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-02-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13014-018-0966-5 |
| _version_ | 1811256148309835776 |
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| author | Yasuhiro Hirano Masakatsu Onozawa Hidehiro Hojo Atsushi Motegi Sadatomo Zenda Kenji Hotta Shunsuke Moriya Hidenobu Tachibana Naoki Nakamura Takashi Kojima Tetsuo Akimoto |
| author_facet | Yasuhiro Hirano Masakatsu Onozawa Hidehiro Hojo Atsushi Motegi Sadatomo Zenda Kenji Hotta Shunsuke Moriya Hidenobu Tachibana Naoki Nakamura Takashi Kojima Tetsuo Akimoto |
| author_sort | Yasuhiro Hirano |
| collection | DOAJ |
| description | Abstract Background The purpose of this study was to perform a dosimetric comparison between proton beam therapy (PBT) and photon radiation therapy in patients with locally advanced esophageal squamous cell carcinoma (ESCC) who were treated with PBT in our institution. In addition, we evaluated the correlation between toxicities and dosimetric parameters, especially the doses to normal lung or heart tissue, to clarify the clinical advantage of PBT over photon radiation therapy. Methods A total of 37 consecutive patients with Stage III thoracic ESCC who had received PBT with or without concurrent chemotherapy between October 2012 and December 2015 were evaluated in this study. The dose distributions of PBT were compared with those of dummy 3-dimensional conformal radiation therapy (3DCRT) and Intensity Modulated Radiation Therapy (IMRT), focusing especially on the doses to organs at risk, such as normal lung and heart tissue. Results Of the 37 patients, the data from 27 patients were analyzed. Among these 27 patients, four patients (15%) developed grade 2 pericardial effusion as a late toxicity. None of the patients developed grade 3 or worse acute or late pulmonary and cardiac toxicities. When the dosimetric parameters between PBT and planned 3DCRT were compared, all the PBT domestic variables for the lung dose except for lung V10 GyE and V15 GyE were significantly lower than those for the dummy 3DCRT plans, and the PBT domestic variables for the heart dose were also significantly lower than those for the dummy 3DCRT plans. When the PBT and IMRT plans were compared, all the PBT domestic variables for the doses to the lung and heart were significantly lower than those for the dummy IMRT plans. Regarding the correlation between the grades of toxicities and the dosimetric parameters, no significant correlation was seen between the occurrence of grade 2 pericardial effusion and the dose to the heart. Conclusions When the dosimetric parameters of the dose distributions for the treatment of patients with locally advanced stage III ESCC were compared between PBT and 3DCRT or IMRT, PBT enabled a significant reduction in the dose to the lung and heart, compared with 3DCRT or IMRT. |
| first_indexed | 2024-04-12T17:36:34Z |
| format | Article |
| id | doaj.art-4d75b9b3d07d496c8e8cc10c8fcfb2c5 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-04-12T17:36:34Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-4d75b9b3d07d496c8e8cc10c8fcfb2c52022-12-22T03:22:58ZengBMCRadiation Oncology1748-717X2018-02-011311910.1186/s13014-018-0966-5Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced esophageal squamous cell carcinomaYasuhiro Hirano0Masakatsu Onozawa1Hidehiro Hojo2Atsushi Motegi3Sadatomo Zenda4Kenji Hotta5Shunsuke Moriya6Hidenobu Tachibana7Naoki Nakamura8Takashi Kojima9Tetsuo Akimoto10Division of Radiation Oncology and Particle Therapy, National Cancer Center Hospital EastDivision of Radiation Oncology and Particle Therapy, National Cancer Center Hospital EastDivision of Radiation Oncology and Particle Therapy, National Cancer Center Hospital EastDivision of Radiation Oncology and Particle Therapy, National Cancer Center Hospital EastDivision of Radiation Oncology and Particle Therapy, National Cancer Center Hospital EastDivision of Radiation Oncology and Particle Therapy, National Cancer Center Hospital EastDivision of Radiation Oncology and Particle Therapy, National Cancer Center Hospital EastDivision of Radiation Oncology and Particle Therapy, National Cancer Center Hospital EastDivision of Radiation Oncology and Particle Therapy, National Cancer Center Hospital EastDivision of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital EastDivision of Radiation Oncology and Particle Therapy, National Cancer Center Hospital EastAbstract Background The purpose of this study was to perform a dosimetric comparison between proton beam therapy (PBT) and photon radiation therapy in patients with locally advanced esophageal squamous cell carcinoma (ESCC) who were treated with PBT in our institution. In addition, we evaluated the correlation between toxicities and dosimetric parameters, especially the doses to normal lung or heart tissue, to clarify the clinical advantage of PBT over photon radiation therapy. Methods A total of 37 consecutive patients with Stage III thoracic ESCC who had received PBT with or without concurrent chemotherapy between October 2012 and December 2015 were evaluated in this study. The dose distributions of PBT were compared with those of dummy 3-dimensional conformal radiation therapy (3DCRT) and Intensity Modulated Radiation Therapy (IMRT), focusing especially on the doses to organs at risk, such as normal lung and heart tissue. Results Of the 37 patients, the data from 27 patients were analyzed. Among these 27 patients, four patients (15%) developed grade 2 pericardial effusion as a late toxicity. None of the patients developed grade 3 or worse acute or late pulmonary and cardiac toxicities. When the dosimetric parameters between PBT and planned 3DCRT were compared, all the PBT domestic variables for the lung dose except for lung V10 GyE and V15 GyE were significantly lower than those for the dummy 3DCRT plans, and the PBT domestic variables for the heart dose were also significantly lower than those for the dummy 3DCRT plans. When the PBT and IMRT plans were compared, all the PBT domestic variables for the doses to the lung and heart were significantly lower than those for the dummy IMRT plans. Regarding the correlation between the grades of toxicities and the dosimetric parameters, no significant correlation was seen between the occurrence of grade 2 pericardial effusion and the dose to the heart. Conclusions When the dosimetric parameters of the dose distributions for the treatment of patients with locally advanced stage III ESCC were compared between PBT and 3DCRT or IMRT, PBT enabled a significant reduction in the dose to the lung and heart, compared with 3DCRT or IMRT.http://link.springer.com/article/10.1186/s13014-018-0966-5Proton beam therapyIMRT3DCRTLocally advanced esophageal cancerIn silico dose distribution |
| spellingShingle | Yasuhiro Hirano Masakatsu Onozawa Hidehiro Hojo Atsushi Motegi Sadatomo Zenda Kenji Hotta Shunsuke Moriya Hidenobu Tachibana Naoki Nakamura Takashi Kojima Tetsuo Akimoto Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced esophageal squamous cell carcinoma Radiation Oncology Proton beam therapy IMRT 3DCRT Locally advanced esophageal cancer In silico dose distribution |
| title | Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced esophageal squamous cell carcinoma |
| title_full | Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced esophageal squamous cell carcinoma |
| title_fullStr | Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced esophageal squamous cell carcinoma |
| title_full_unstemmed | Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced esophageal squamous cell carcinoma |
| title_short | Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced esophageal squamous cell carcinoma |
| title_sort | dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced esophageal squamous cell carcinoma |
| topic | Proton beam therapy IMRT 3DCRT Locally advanced esophageal cancer In silico dose distribution |
| url | http://link.springer.com/article/10.1186/s13014-018-0966-5 |
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