Peripubertal exposure to male chemosignals accelerates vaginal opening and induces male-directed odor preference in female mice
Reproductive physiology in female mouse is profoundly affected by male odor. A well-known effect of male odor is the acceleration of puberty onset in prepubertal female mice exposed to male urine. Whether peripubertal exposure to male odor also influences female sexual behavior in adulthood is poorl...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-03-01
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| Series: | Frontiers in Ecology and Evolution |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fevo.2015.00034/full |
| _version_ | 1811266213629657088 |
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| author | Mélanie eJouhanneau Camille eGoudet Chantal eMoussu Takuya eTashiro Bruno eBuatois Kenji eMori Guila eGanem Matthieu eKELLER |
| author_facet | Mélanie eJouhanneau Camille eGoudet Chantal eMoussu Takuya eTashiro Bruno eBuatois Kenji eMori Guila eGanem Matthieu eKELLER |
| author_sort | Mélanie eJouhanneau |
| collection | DOAJ |
| description | Reproductive physiology in female mouse is profoundly affected by male odor. A well-known effect of male odor is the acceleration of puberty onset in prepubertal female mice exposed to male urine. Whether peripubertal exposure to male odor also influences female sexual behavior in adulthood is poorly known. Recently, we reported that female mice exposed to male-soiled bedding showed advanced vaginal opening associated with early expression of male-directed odor preference in adulthood. The aim of the present study is to determine whether peripubertal exposure to male urinary chemosignals affects both occurrence of vaginal opening and attraction to male odor at older age in female mice. Therefore, we exposed female mice to (1R, 5S, 7R)-3,4-dehydro-exo-brevicomin (DHB), 6-hydroxy-6-methyl-3-heptanone (HMH) and (S)-2-sec-butyl-4,5-dihydrothiazole (SBT), individually or in mixture, from postnatal day (PD) 21 to PD38 and monitored the occurrence of vaginal opening. We measured then the time that the female mice spent sniffing male and female mouse urinary volatiles at PD45. As expected, peripubertal exposure to DHB, HMH or SBT accelerated vaginal opening in female mice. In addition, we showed that exposure to a mixture of these three compounds induced expression of male-directed odor preference at PD45, contrary to the single exposure to each of these molecules. In conclusion, the volatile compounds DHB, HMH and SBT in urine of male mice influence both occurrence of vaginal opening and adult expression of male-directed odor preference in female mice. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2296-701X |
| language | English |
| last_indexed | 2024-04-12T20:39:12Z |
| publishDate | 2015-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Ecology and Evolution |
| spelling | doaj.art-4d75be3affb5420ca5deae62ce794dd72022-12-22T03:17:29ZengFrontiers Media S.A.Frontiers in Ecology and Evolution2296-701X2015-03-01310.3389/fevo.2015.00034124247Peripubertal exposure to male chemosignals accelerates vaginal opening and induces male-directed odor preference in female miceMélanie eJouhanneau0Camille eGoudet1Chantal eMoussu2Takuya eTashiro3Bruno eBuatois4Kenji eMori5Guila eGanem6Matthieu eKELLER7Laboratoire de Physiologie de la Reproduction et des Comportements, UMR 7247 INRA/CNRS/Université de Tours, INRA Val de LoireLaboratoire de Physiologie de la Reproduction et des Comportements, UMR 7247 INRA/CNRS/Université de Tours, INRA Val de LoireLaboratoire de Physiologie de la Reproduction et des Comportements, UMR 7247 INRA/CNRS/Université de Tours, INRA Val de LoireProgram for Drug Discovery and Medical Technology Platforms, RIKEN Research Cluster for InnovationCentre d’Ecologie Fonctionnelle & Evolutive, UMR 5175 CNRS/Université Montpellier/SupAgroProgram for Drug Discovery and Medical Technology Platforms, RIKEN Research Cluster for InnovationInstitut des Sciences de l’Evolution, UMR 5554 Université Montpellier/CNRS/IRDLaboratoire de Physiologie de la Reproduction et des Comportements, UMR 7247 INRA/CNRS/Université de Tours, INRA Val de LoireReproductive physiology in female mouse is profoundly affected by male odor. A well-known effect of male odor is the acceleration of puberty onset in prepubertal female mice exposed to male urine. Whether peripubertal exposure to male odor also influences female sexual behavior in adulthood is poorly known. Recently, we reported that female mice exposed to male-soiled bedding showed advanced vaginal opening associated with early expression of male-directed odor preference in adulthood. The aim of the present study is to determine whether peripubertal exposure to male urinary chemosignals affects both occurrence of vaginal opening and attraction to male odor at older age in female mice. Therefore, we exposed female mice to (1R, 5S, 7R)-3,4-dehydro-exo-brevicomin (DHB), 6-hydroxy-6-methyl-3-heptanone (HMH) and (S)-2-sec-butyl-4,5-dihydrothiazole (SBT), individually or in mixture, from postnatal day (PD) 21 to PD38 and monitored the occurrence of vaginal opening. We measured then the time that the female mice spent sniffing male and female mouse urinary volatiles at PD45. As expected, peripubertal exposure to DHB, HMH or SBT accelerated vaginal opening in female mice. In addition, we showed that exposure to a mixture of these three compounds induced expression of male-directed odor preference at PD45, contrary to the single exposure to each of these molecules. In conclusion, the volatile compounds DHB, HMH and SBT in urine of male mice influence both occurrence of vaginal opening and adult expression of male-directed odor preference in female mice.http://journal.frontiersin.org/Journal/10.3389/fevo.2015.00034/fullPubertySexual Behaviorchemical communication34-dehydro-exo-brevicomin6-hydroxy-6-methyl-3-heptanone |
| spellingShingle | Mélanie eJouhanneau Camille eGoudet Chantal eMoussu Takuya eTashiro Bruno eBuatois Kenji eMori Guila eGanem Matthieu eKELLER Peripubertal exposure to male chemosignals accelerates vaginal opening and induces male-directed odor preference in female mice Frontiers in Ecology and Evolution Puberty Sexual Behavior chemical communication 3 4-dehydro-exo-brevicomin 6-hydroxy-6-methyl-3-heptanone |
| title | Peripubertal exposure to male chemosignals accelerates vaginal opening and induces male-directed odor preference in female mice |
| title_full | Peripubertal exposure to male chemosignals accelerates vaginal opening and induces male-directed odor preference in female mice |
| title_fullStr | Peripubertal exposure to male chemosignals accelerates vaginal opening and induces male-directed odor preference in female mice |
| title_full_unstemmed | Peripubertal exposure to male chemosignals accelerates vaginal opening and induces male-directed odor preference in female mice |
| title_short | Peripubertal exposure to male chemosignals accelerates vaginal opening and induces male-directed odor preference in female mice |
| title_sort | peripubertal exposure to male chemosignals accelerates vaginal opening and induces male directed odor preference in female mice |
| topic | Puberty Sexual Behavior chemical communication 3 4-dehydro-exo-brevicomin 6-hydroxy-6-methyl-3-heptanone |
| url | http://journal.frontiersin.org/Journal/10.3389/fevo.2015.00034/full |
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