The type 1 diabetes susceptibility locus Idd5 favours robust neonatal development of highly autoreactive regulatory T cells in the NOD mouse

The type 1 diabetes susceptibility locus Idd5 favours robust neonatal development of highly autoreactive regulatory T cells in the NOD mouse

Regulatory T lymphocytes expressing the transcription factor Foxp3 (Tregs) play an important role in the prevention of autoimmune diseases and other immunopathologies. Aberrations in Treg-mediated immunosuppression are therefore thought to be involved in the development of autoimmune pathologies, bu...

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Bibliographic Details
Main Authors: Jérémy C. Santamaria, Sylvia Vuillier, Ariel O. Galindo-Albarrán, Sarah Castan, Claire Detraves, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
thymus
regulatory T cells
immune tolerance
type 1 diabetes
Idd5
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1358459/full

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