Antidiuretic hormone and the activation of glucose production during high intensity aerobic exercise
Objective: This study aimed to investigate the role that antidiuretic hormone (ADH) may play in the activation of glucose production during high intensity aerobic exercise. Materials/methods: This study was part of larger study based on a repeated measures cross-over study design and involved ten ad...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Metabolism Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589936821000372 |
| _version_ | 1819101100718948352 |
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| author | Vinutha B. Shetty Grant Smith Nirubasini Paramalingam Heather C. Roby Elizabeth A. Davis Timothy W. Jones Paul A. Fournier |
| author_facet | Vinutha B. Shetty Grant Smith Nirubasini Paramalingam Heather C. Roby Elizabeth A. Davis Timothy W. Jones Paul A. Fournier |
| author_sort | Vinutha B. Shetty |
| collection | DOAJ |
| description | Objective: This study aimed to investigate the role that antidiuretic hormone (ADH) may play in the activation of glucose production during high intensity aerobic exercise. Materials/methods: This study was part of larger study based on a repeated measures cross-over study design and involved ten adult participants who exercised in the morning at 80 % V̇O2peak for up to 40 min or until exhaustion. During and after exercise, the participants were subjected to a morning euglycaemic/euinsulinaemic clamp while [6,6-2H2]glucose was infused and blood sampled to measure the endogenous rate of glucose appearance (Ra) and ADH levels. Results: The levels of plasma ADH were 1.8 ± 0.2 pmol/L (mean ± SEM) at rest and increased to 10.5 ± 2.1 pmol/L at the end of exercise (mean ± SEM), which lasted 8.5–40 min. In response to exercise, glucose Ra also rose significantly (p < 0.05), but there was no significant association between changes in ADH levels and glucose Ra (r = 0.49; p = 0.150). Conclusions: Although the significant increase in glucose Ra and ADH levels during high intensity aerobic exercise suggest for the first time that these processes may be causally related, there was no significant association between these variables, maybe because of the small sample size and varying exercise durations. Hence, the importance of the causal role that ADH may play in the exercise-mediated activation of hepatic glucose production warrants further in depth investigations. |
| first_indexed | 2024-12-22T01:13:18Z |
| format | Article |
| id | doaj.art-4d7713d811a447658c8ea65b1c45d546 |
| institution | Directory Open Access Journal |
| issn | 2589-9368 |
| language | English |
| last_indexed | 2024-12-22T01:13:18Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Metabolism Open |
| spelling | doaj.art-4d7713d811a447658c8ea65b1c45d5462022-12-21T18:43:55ZengElsevierMetabolism Open2589-93682021-09-0111100113Antidiuretic hormone and the activation of glucose production during high intensity aerobic exerciseVinutha B. Shetty0Grant Smith1Nirubasini Paramalingam2Heather C. Roby3Elizabeth A. Davis4Timothy W. Jones5Paul A. Fournier6Department of Endocrinology and Diabetes, Perth Children Hospital, Perth, W.A., Australia; Division of Paediatrics Within the Medical School, The University of Western Australia, Perth, W.A., Australia; Children's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, W.A., Australia; Corresponding author. Department of Endocrinology and Diabetes, Perth Children's Hospital 15 Hospital Avenue, Nedlands, Perth, 6009, Australia.Children's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, W.A., AustraliaDepartment of Endocrinology and Diabetes, Perth Children Hospital, Perth, W.A., Australia; Division of Paediatrics Within the Medical School, The University of Western Australia, Perth, W.A., Australia; Department of Exercise Science and Health, School of Human Sciences, The University of Western Australia, Perth, W.A., Australia; Children's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, W.A., AustraliaChildren's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, W.A., AustraliaDepartment of Endocrinology and Diabetes, Perth Children Hospital, Perth, W.A., Australia; Division of Paediatrics Within the Medical School, The University of Western Australia, Perth, W.A., Australia; Children's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, W.A., AustraliaDepartment of Endocrinology and Diabetes, Perth Children Hospital, Perth, W.A., Australia; Division of Paediatrics Within the Medical School, The University of Western Australia, Perth, W.A., Australia; Children's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, W.A., AustraliaDepartment of Exercise Science and Health, School of Human Sciences, The University of Western Australia, Perth, W.A., AustraliaObjective: This study aimed to investigate the role that antidiuretic hormone (ADH) may play in the activation of glucose production during high intensity aerobic exercise. Materials/methods: This study was part of larger study based on a repeated measures cross-over study design and involved ten adult participants who exercised in the morning at 80 % V̇O2peak for up to 40 min or until exhaustion. During and after exercise, the participants were subjected to a morning euglycaemic/euinsulinaemic clamp while [6,6-2H2]glucose was infused and blood sampled to measure the endogenous rate of glucose appearance (Ra) and ADH levels. Results: The levels of plasma ADH were 1.8 ± 0.2 pmol/L (mean ± SEM) at rest and increased to 10.5 ± 2.1 pmol/L at the end of exercise (mean ± SEM), which lasted 8.5–40 min. In response to exercise, glucose Ra also rose significantly (p < 0.05), but there was no significant association between changes in ADH levels and glucose Ra (r = 0.49; p = 0.150). Conclusions: Although the significant increase in glucose Ra and ADH levels during high intensity aerobic exercise suggest for the first time that these processes may be causally related, there was no significant association between these variables, maybe because of the small sample size and varying exercise durations. Hence, the importance of the causal role that ADH may play in the exercise-mediated activation of hepatic glucose production warrants further in depth investigations.http://www.sciencedirect.com/science/article/pii/S2589936821000372Type 1 diabetesGlucose productionBlood glucose levelAntidiuretic hormoneADHVasopressin |
| spellingShingle | Vinutha B. Shetty Grant Smith Nirubasini Paramalingam Heather C. Roby Elizabeth A. Davis Timothy W. Jones Paul A. Fournier Antidiuretic hormone and the activation of glucose production during high intensity aerobic exercise Metabolism Open Type 1 diabetes Glucose production Blood glucose level Antidiuretic hormone ADH Vasopressin |
| title | Antidiuretic hormone and the activation of glucose production during high intensity aerobic exercise |
| title_full | Antidiuretic hormone and the activation of glucose production during high intensity aerobic exercise |
| title_fullStr | Antidiuretic hormone and the activation of glucose production during high intensity aerobic exercise |
| title_full_unstemmed | Antidiuretic hormone and the activation of glucose production during high intensity aerobic exercise |
| title_short | Antidiuretic hormone and the activation of glucose production during high intensity aerobic exercise |
| title_sort | antidiuretic hormone and the activation of glucose production during high intensity aerobic exercise |
| topic | Type 1 diabetes Glucose production Blood glucose level Antidiuretic hormone ADH Vasopressin |
| url | http://www.sciencedirect.com/science/article/pii/S2589936821000372 |
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