Pathogenic roles and diagnostic utility of interleukin-18 in autoinflammatory diseases
Interleukin (IL)-18 is a pleiotropic, pro-inflammatory cytokine involved in the regulation of innate and adaptive immune responses. IL-18 has attracted increasing attention as a key mediator in autoinflammatory diseases associated with the development of macrophage activation syndrome (MAS) includin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.951535/full |
| _version_ | 1828413403047133184 |
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| author | Masaki Shimizu Syuji Takei Masaaki Mori Akihiro Yachie |
| author_facet | Masaki Shimizu Syuji Takei Masaaki Mori Akihiro Yachie |
| author_sort | Masaki Shimizu |
| collection | DOAJ |
| description | Interleukin (IL)-18 is a pleiotropic, pro-inflammatory cytokine involved in the regulation of innate and adaptive immune responses. IL-18 has attracted increasing attention as a key mediator in autoinflammatory diseases associated with the development of macrophage activation syndrome (MAS) including systemic juvenile idiopathic arthritis and adult-onset Still’s disease. In these diseases, dysregulation of inflammasome activity and overproduction of IL-18 might be associated with the development of MAS by inducing natural killer cell dysfunction. Serum IL-18 levels are high in patients with these diseases and therefore are useful for the diagnosis and monitoring of disease activity. In contrast, a recent study revealed the overproduction of IL-18 was present in cases of autoinflammation without susceptibility to MAS such as pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome. The pathogenic and causative roles of IL-18 remain unclear in these autoinflammatory diseases. Further investigations are necessary to clarify the role of IL-18 and its importance as a therapeutic target in the pathogenesis of autoinflammatory diseases. |
| first_indexed | 2024-12-10T13:09:03Z |
| format | Article |
| id | doaj.art-4d798457ed5e43b9b7d01831747fcccc |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T13:09:03Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-4d798457ed5e43b9b7d01831747fcccc2022-12-22T01:47:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-09-011310.3389/fimmu.2022.951535951535Pathogenic roles and diagnostic utility of interleukin-18 in autoinflammatory diseasesMasaki Shimizu0Syuji Takei1Masaaki Mori2Akihiro Yachie3Department of Child Health and Development, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Pediatrics, Field of Developmental Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, JapanDepartment of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, JapanDivision of Medical Safety, Kanazawa University Hospital, Kanazawa, JapanInterleukin (IL)-18 is a pleiotropic, pro-inflammatory cytokine involved in the regulation of innate and adaptive immune responses. IL-18 has attracted increasing attention as a key mediator in autoinflammatory diseases associated with the development of macrophage activation syndrome (MAS) including systemic juvenile idiopathic arthritis and adult-onset Still’s disease. In these diseases, dysregulation of inflammasome activity and overproduction of IL-18 might be associated with the development of MAS by inducing natural killer cell dysfunction. Serum IL-18 levels are high in patients with these diseases and therefore are useful for the diagnosis and monitoring of disease activity. In contrast, a recent study revealed the overproduction of IL-18 was present in cases of autoinflammation without susceptibility to MAS such as pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome. The pathogenic and causative roles of IL-18 remain unclear in these autoinflammatory diseases. Further investigations are necessary to clarify the role of IL-18 and its importance as a therapeutic target in the pathogenesis of autoinflammatory diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2022.951535/fullIL-18systemic juvenile idiopathic arthritisadult Still's diseaseinflammasomesNLRC4pyogenic sterile arthritis |
| spellingShingle | Masaki Shimizu Syuji Takei Masaaki Mori Akihiro Yachie Pathogenic roles and diagnostic utility of interleukin-18 in autoinflammatory diseases Frontiers in Immunology IL-18 systemic juvenile idiopathic arthritis adult Still's disease inflammasomes NLRC4 pyogenic sterile arthritis |
| title | Pathogenic roles and diagnostic utility of interleukin-18 in autoinflammatory diseases |
| title_full | Pathogenic roles and diagnostic utility of interleukin-18 in autoinflammatory diseases |
| title_fullStr | Pathogenic roles and diagnostic utility of interleukin-18 in autoinflammatory diseases |
| title_full_unstemmed | Pathogenic roles and diagnostic utility of interleukin-18 in autoinflammatory diseases |
| title_short | Pathogenic roles and diagnostic utility of interleukin-18 in autoinflammatory diseases |
| title_sort | pathogenic roles and diagnostic utility of interleukin 18 in autoinflammatory diseases |
| topic | IL-18 systemic juvenile idiopathic arthritis adult Still's disease inflammasomes NLRC4 pyogenic sterile arthritis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.951535/full |
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