Pathogenic roles and diagnostic utility of interleukin-18 in autoinflammatory diseases

Interleukin (IL)-18 is a pleiotropic, pro-inflammatory cytokine involved in the regulation of innate and adaptive immune responses. IL-18 has attracted increasing attention as a key mediator in autoinflammatory diseases associated with the development of macrophage activation syndrome (MAS) includin...

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Bibliographic Details
Main Authors: Masaki Shimizu, Syuji Takei, Masaaki Mori, Akihiro Yachie
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.951535/full