Pathogenic roles and diagnostic utility of interleukin-18 in autoinflammatory diseases
Interleukin (IL)-18 is a pleiotropic, pro-inflammatory cytokine involved in the regulation of innate and adaptive immune responses. IL-18 has attracted increasing attention as a key mediator in autoinflammatory diseases associated with the development of macrophage activation syndrome (MAS) includin...
Main Authors: | Masaki Shimizu, Syuji Takei, Masaaki Mori, Akihiro Yachie |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-09-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.951535/full |
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