Serum vitamin C levels: a comparison between febrile children with or without seizure
Objective: An imbalance has been reported in the oxidant-antioxidant system of infants with febrile convulsion. This study aimed to compare serum vitamin C levels between febrile children with or without seizures. Materials and Method: This multicenter case-control study was conducted on febrile inf...
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| Format: | Article |
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Mashhad University of Medical Sciences
2022-09-01
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| Series: | Reviews in Clinical Medicine |
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| Online Access: | https://rcm.mums.ac.ir/article_21447_3a0b099a216b6b7bf5b117cca4a96b8f.pdf |
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| author | Forough Rakhshanizadeh Farhad Heydarian Elahe Heidari Lida Jarahi hassan kani |
| author_facet | Forough Rakhshanizadeh Farhad Heydarian Elahe Heidari Lida Jarahi hassan kani |
| author_sort | Forough Rakhshanizadeh |
| collection | DOAJ |
| description | Objective: An imbalance has been reported in the oxidant-antioxidant system of infants with febrile convulsion. This study aimed to compare serum vitamin C levels between febrile children with or without seizures. Materials and Method: This multicenter case-control study was conducted on febrile infants and children who were referred to the pediatric emergency wards of Mashhad University of Medical Science. The subjects were equally divided into two febrile groups of case (with seizure) and control (without seizures). Visible Spectrophotometer was used to determine the total vitamin C level.Results: In total, 100 febrile children were included in this study. Based on the results, there was no statistically significant difference between the two groups in terms of age, gender, and family history of febrile convulsion (FC) (P>0.05). The mean vitamin C levels in the case and control groups were 42.73±7.2 and 78.59±11.1 µg/l, respectively. There was a significant difference between the groups regarding the vitamin C level (P<0.001). Regression analysis revealed that age (P=0.74), gender (P=0.66), and family history of febrile convulsion (P=0.52) had not any correlation with vitamin C levels. On the other hand, the vitamin C levels was associated with FC (P=0.001).Conclusion: The serum levels of vitamin C in the children with febrile seizure were lower than those in the control group. Thus, the reduced vitamin C levels can be considered as a predisposing factor for FC. |
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| format | Article |
| id | doaj.art-4d7bbf5e0b8b4fa9935bae3c8345662d |
| institution | Directory Open Access Journal |
| issn | 2345-6256 2345-6892 |
| language | English |
| last_indexed | 2024-04-09T18:19:50Z |
| publishDate | 2022-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Reviews in Clinical Medicine |
| spelling | doaj.art-4d7bbf5e0b8b4fa9935bae3c8345662d2023-04-12T08:29:59ZengMashhad University of Medical SciencesReviews in Clinical Medicine2345-62562345-68922022-09-019313013310.22038/rcm.2022.68759.142121447Serum vitamin C levels: a comparison between febrile children with or without seizureForough Rakhshanizadeh0Farhad Heydarian1Elahe Heidari2Lida Jarahi3hassan kani4Assistant professor, Department of pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran1Professor of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of pediatrics, Mashhad University of Medical Sciences, Mashhad, IranMD, MPH, of Community Medicine, Associate Professor, Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran4Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranObjective: An imbalance has been reported in the oxidant-antioxidant system of infants with febrile convulsion. This study aimed to compare serum vitamin C levels between febrile children with or without seizures. Materials and Method: This multicenter case-control study was conducted on febrile infants and children who were referred to the pediatric emergency wards of Mashhad University of Medical Science. The subjects were equally divided into two febrile groups of case (with seizure) and control (without seizures). Visible Spectrophotometer was used to determine the total vitamin C level.Results: In total, 100 febrile children were included in this study. Based on the results, there was no statistically significant difference between the two groups in terms of age, gender, and family history of febrile convulsion (FC) (P>0.05). The mean vitamin C levels in the case and control groups were 42.73±7.2 and 78.59±11.1 µg/l, respectively. There was a significant difference between the groups regarding the vitamin C level (P<0.001). Regression analysis revealed that age (P=0.74), gender (P=0.66), and family history of febrile convulsion (P=0.52) had not any correlation with vitamin C levels. On the other hand, the vitamin C levels was associated with FC (P=0.001).Conclusion: The serum levels of vitamin C in the children with febrile seizure were lower than those in the control group. Thus, the reduced vitamin C levels can be considered as a predisposing factor for FC.https://rcm.mums.ac.ir/article_21447_3a0b099a216b6b7bf5b117cca4a96b8f.pdffebrile seizurevitamin cantioxidantsoxidative stress |
| spellingShingle | Forough Rakhshanizadeh Farhad Heydarian Elahe Heidari Lida Jarahi hassan kani Serum vitamin C levels: a comparison between febrile children with or without seizure Reviews in Clinical Medicine febrile seizure vitamin c antioxidants oxidative stress |
| title | Serum vitamin C levels: a comparison between febrile children with or without seizure |
| title_full | Serum vitamin C levels: a comparison between febrile children with or without seizure |
| title_fullStr | Serum vitamin C levels: a comparison between febrile children with or without seizure |
| title_full_unstemmed | Serum vitamin C levels: a comparison between febrile children with or without seizure |
| title_short | Serum vitamin C levels: a comparison between febrile children with or without seizure |
| title_sort | serum vitamin c levels a comparison between febrile children with or without seizure |
| topic | febrile seizure vitamin c antioxidants oxidative stress |
| url | https://rcm.mums.ac.ir/article_21447_3a0b099a216b6b7bf5b117cca4a96b8f.pdf |
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