Cinacalcet may suppress kidney enlargement in hemodialysis patients with autosomal dominant polycystic kidney disease
Abstract A massively enlarged kidney can impact quality of life of autosomal dominant polycystic kidney disease (ADPKD) patients. A recent in vitro study demonstrated that an allosteric modulator of the calcium sensing receptor decreases adenosine-3′,5′-cyclic monophosphate, an important factor for...
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| Format: | Article |
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Nature Portfolio
2021-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-89480-1 |
| _version_ | 1818991684395991040 |
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| author | Shinya Nakatani Kozo Nishide Senji Okuno Eiji Ishimura Daijiro Kabata Fumiyuki Morioka Yuri Machiba Hideki Uedono Akihiro Tsuda Shigeichi Shoji Masaaki Inaba Katsuhito Mori Tomoyuki Yamakawa Masanori Emoto |
| author_facet | Shinya Nakatani Kozo Nishide Senji Okuno Eiji Ishimura Daijiro Kabata Fumiyuki Morioka Yuri Machiba Hideki Uedono Akihiro Tsuda Shigeichi Shoji Masaaki Inaba Katsuhito Mori Tomoyuki Yamakawa Masanori Emoto |
| author_sort | Shinya Nakatani |
| collection | DOAJ |
| description | Abstract A massively enlarged kidney can impact quality of life of autosomal dominant polycystic kidney disease (ADPKD) patients. A recent in vitro study demonstrated that an allosteric modulator of the calcium sensing receptor decreases adenosine-3′,5′-cyclic monophosphate, an important factor for kidney enlargement in ADPKD. Therefore, the present study was performed to determine whether cinacalcet, a calcium sensing receptor agonist, suppresses kidney enlargement in hemodialysis patients with ADPKD. Alteration of total kidney volume together with clinical parameters was retrospectively examined in 12 hemodialysis patients with ADPKD treated at a single institution in Japan. In the non-cinacalcet group with longer hemodialysis duration (n = 5), total kidney volume had an annual increase of 4.19 ± 1.71% during an overall period of 877 ± 494 days. In contrast, the annual rate of increase in total kidney volume in the cinacalcet group (n = 7) was significantly suppressed after cinacalcet treatment, from 3.26 ± 2.87% during a period of 734 ± 352 days before the start of cinacalcet to − 4.71 ± 6.42% during 918 ± 524 days after initiation of treatment (p = 0.047). The present findings showed that cinacalcet could be a novel therapeutic tool for suppression of kidney enlargement in hemodialysis patients with ADPKD. |
| first_indexed | 2024-12-20T20:14:11Z |
| format | Article |
| id | doaj.art-4d7d233e64e54f819c340bec880d0e73 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T20:14:11Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4d7d233e64e54f819c340bec880d0e732022-12-21T19:27:45ZengNature PortfolioScientific Reports2045-23222021-05-0111111010.1038/s41598-021-89480-1Cinacalcet may suppress kidney enlargement in hemodialysis patients with autosomal dominant polycystic kidney diseaseShinya Nakatani0Kozo Nishide1Senji Okuno2Eiji Ishimura3Daijiro Kabata4Fumiyuki Morioka5Yuri Machiba6Hideki Uedono7Akihiro Tsuda8Shigeichi Shoji9Masaaki Inaba10Katsuhito Mori11Tomoyuki Yamakawa12Masanori Emoto13Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of MedicineDepartment of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of MedicineKidney Center, Shirasagi HospitalDepartment of Nephrology, Meijibashi HospitalDepartment of Medical Statistics, Medicine, Osaka City University Graduate School of MedicineDepartment of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of MedicineDepartment of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of MedicineDepartment of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of MedicineDepartment of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of MedicineKidney Center, Shirasagi HospitalDepartment of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of MedicineDepartment of Nephrology, Osaka City University Graduate School of MedicineKidney Center, Shirasagi HospitalDepartment of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of MedicineAbstract A massively enlarged kidney can impact quality of life of autosomal dominant polycystic kidney disease (ADPKD) patients. A recent in vitro study demonstrated that an allosteric modulator of the calcium sensing receptor decreases adenosine-3′,5′-cyclic monophosphate, an important factor for kidney enlargement in ADPKD. Therefore, the present study was performed to determine whether cinacalcet, a calcium sensing receptor agonist, suppresses kidney enlargement in hemodialysis patients with ADPKD. Alteration of total kidney volume together with clinical parameters was retrospectively examined in 12 hemodialysis patients with ADPKD treated at a single institution in Japan. In the non-cinacalcet group with longer hemodialysis duration (n = 5), total kidney volume had an annual increase of 4.19 ± 1.71% during an overall period of 877 ± 494 days. In contrast, the annual rate of increase in total kidney volume in the cinacalcet group (n = 7) was significantly suppressed after cinacalcet treatment, from 3.26 ± 2.87% during a period of 734 ± 352 days before the start of cinacalcet to − 4.71 ± 6.42% during 918 ± 524 days after initiation of treatment (p = 0.047). The present findings showed that cinacalcet could be a novel therapeutic tool for suppression of kidney enlargement in hemodialysis patients with ADPKD.https://doi.org/10.1038/s41598-021-89480-1 |
| spellingShingle | Shinya Nakatani Kozo Nishide Senji Okuno Eiji Ishimura Daijiro Kabata Fumiyuki Morioka Yuri Machiba Hideki Uedono Akihiro Tsuda Shigeichi Shoji Masaaki Inaba Katsuhito Mori Tomoyuki Yamakawa Masanori Emoto Cinacalcet may suppress kidney enlargement in hemodialysis patients with autosomal dominant polycystic kidney disease Scientific Reports |
| title | Cinacalcet may suppress kidney enlargement in hemodialysis patients with autosomal dominant polycystic kidney disease |
| title_full | Cinacalcet may suppress kidney enlargement in hemodialysis patients with autosomal dominant polycystic kidney disease |
| title_fullStr | Cinacalcet may suppress kidney enlargement in hemodialysis patients with autosomal dominant polycystic kidney disease |
| title_full_unstemmed | Cinacalcet may suppress kidney enlargement in hemodialysis patients with autosomal dominant polycystic kidney disease |
| title_short | Cinacalcet may suppress kidney enlargement in hemodialysis patients with autosomal dominant polycystic kidney disease |
| title_sort | cinacalcet may suppress kidney enlargement in hemodialysis patients with autosomal dominant polycystic kidney disease |
| url | https://doi.org/10.1038/s41598-021-89480-1 |
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