Hemoptysis caused by Parvimonas micra: case report and literature review
BackgroundParvimonas micra (P. micra), a Gram-positive anaerobic bacterium, exhibits colonization tendencies on oral mucosal and skin surfaces, potentially evolving into a pathogenic entity associated with diverse diseases. The diagnostic trajectory for P. micra-related diseases encounters delays, o...
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| Format: | Article |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1307902/full |
| _version_ | 1797319746023063552 |
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| author | Axue Shao Axue Shao Qingqing He Qingqing He Xin Jiao Xin Jiao Jianbo Liu Jianbo Liu |
| author_facet | Axue Shao Axue Shao Qingqing He Qingqing He Xin Jiao Xin Jiao Jianbo Liu Jianbo Liu |
| author_sort | Axue Shao |
| collection | DOAJ |
| description | BackgroundParvimonas micra (P. micra), a Gram-positive anaerobic bacterium, exhibits colonization tendencies on oral mucosal and skin surfaces, potentially evolving into a pathogenic entity associated with diverse diseases. The diagnostic trajectory for P. micra-related diseases encounters delays, often with severe consequences, including fatality, attributed to the absence of symptom specificity and challenges in culture. The absence of a consensus on the diagnostic and therapeutic approaches to P. micra exacerbates the complexity of addressing associated conditions. This study aims to elucidate and scrutinize the clinical manifestations linked to P. micra, drawing insights from an extensive literature review of pertinent case reports.Case presentationA 53-year-old male sought medical attention at our institution presenting with recurrent hemoptysis. Empirical treatment was initiated while awaiting pathogen culture results; however, the patient’s symptoms persisted. Subsequent metagenomic next-generation sequencing (mNGS) analysis revealed a pulmonary infection attributable to P. micra. Resolution of symptoms occurred following treatment with piperacillin sulbactam sodium and moxifloxacin hydrochloride. A comprehensive literature review, utilizing the PubMed database, was conducted to assess case reports over the last decade where P. micra was identified as the causative agent.ConclusionThe literature analysis underscores the predilection of P. micra for immunocompromised populations afflicted by cardiovascular diseases, diabetes, orthopedic conditions, and tumors. Risk factors, including oral and periodontal hygiene, smoking, and alcohol consumption, were found to be associated with P. micra infections. Clinical manifestations encompassed fever, cough, sputum production, and back pain, potentially leading to severe outcomes such as Spondylodiscitis, septic arthritis, lung abscess, bacteremia, sepsis, and mortality. While conventional bacterial culture remains the primary diagnostic tool, emerging technologies like mNGS offer alternative considerations. In terms of treatment modalities, β-lactam antibiotics and nitroimidazoles predominated, exhibiting recovery rates of 56.10% (46/82) and 23.17% (19/82), respectively. This case report and literature review collectively aim to enhance awareness among clinicians and laboratory medicine professionals regarding the intricacies of P. micra-associated infections. |
| first_indexed | 2024-03-08T04:12:24Z |
| format | Article |
| id | doaj.art-4d7d45eecc5b4863985873346a552b82 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-08T04:12:24Z |
| publishDate | 2024-02-01 |
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| series | Frontiers in Public Health |
| spelling | doaj.art-4d7d45eecc5b4863985873346a552b822024-02-08T16:45:33ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-02-011110.3389/fpubh.2023.13079021307902Hemoptysis caused by Parvimonas micra: case report and literature reviewAxue Shao0Axue Shao1Qingqing He2Qingqing He3Xin Jiao4Xin Jiao5Jianbo Liu6Jianbo Liu7The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, ChinaBackgroundParvimonas micra (P. micra), a Gram-positive anaerobic bacterium, exhibits colonization tendencies on oral mucosal and skin surfaces, potentially evolving into a pathogenic entity associated with diverse diseases. The diagnostic trajectory for P. micra-related diseases encounters delays, often with severe consequences, including fatality, attributed to the absence of symptom specificity and challenges in culture. The absence of a consensus on the diagnostic and therapeutic approaches to P. micra exacerbates the complexity of addressing associated conditions. This study aims to elucidate and scrutinize the clinical manifestations linked to P. micra, drawing insights from an extensive literature review of pertinent case reports.Case presentationA 53-year-old male sought medical attention at our institution presenting with recurrent hemoptysis. Empirical treatment was initiated while awaiting pathogen culture results; however, the patient’s symptoms persisted. Subsequent metagenomic next-generation sequencing (mNGS) analysis revealed a pulmonary infection attributable to P. micra. Resolution of symptoms occurred following treatment with piperacillin sulbactam sodium and moxifloxacin hydrochloride. A comprehensive literature review, utilizing the PubMed database, was conducted to assess case reports over the last decade where P. micra was identified as the causative agent.ConclusionThe literature analysis underscores the predilection of P. micra for immunocompromised populations afflicted by cardiovascular diseases, diabetes, orthopedic conditions, and tumors. Risk factors, including oral and periodontal hygiene, smoking, and alcohol consumption, were found to be associated with P. micra infections. Clinical manifestations encompassed fever, cough, sputum production, and back pain, potentially leading to severe outcomes such as Spondylodiscitis, septic arthritis, lung abscess, bacteremia, sepsis, and mortality. While conventional bacterial culture remains the primary diagnostic tool, emerging technologies like mNGS offer alternative considerations. In terms of treatment modalities, β-lactam antibiotics and nitroimidazoles predominated, exhibiting recovery rates of 56.10% (46/82) and 23.17% (19/82), respectively. This case report and literature review collectively aim to enhance awareness among clinicians and laboratory medicine professionals regarding the intricacies of P. micra-associated infections.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1307902/fullParvimonas micrahemoptysiscase reportliterature reviewMNGs |
| spellingShingle | Axue Shao Axue Shao Qingqing He Qingqing He Xin Jiao Xin Jiao Jianbo Liu Jianbo Liu Hemoptysis caused by Parvimonas micra: case report and literature review Frontiers in Public Health Parvimonas micra hemoptysis case report literature review MNGs |
| title | Hemoptysis caused by Parvimonas micra: case report and literature review |
| title_full | Hemoptysis caused by Parvimonas micra: case report and literature review |
| title_fullStr | Hemoptysis caused by Parvimonas micra: case report and literature review |
| title_full_unstemmed | Hemoptysis caused by Parvimonas micra: case report and literature review |
| title_short | Hemoptysis caused by Parvimonas micra: case report and literature review |
| title_sort | hemoptysis caused by parvimonas micra case report and literature review |
| topic | Parvimonas micra hemoptysis case report literature review MNGs |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1307902/full |
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