Macrophage Related Chronic Inflammation in Non-Healing Wounds
Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic wounds, and macrophage malfunction is considered as a major contributor thereof. In this review, we describe the origin and heterogeneity of macrophages during wound healing, and compare macrophage functio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.681710/full |
| _version_ | 1818671797150679040 |
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| author | Meirong Li Meirong Li Meirong Li Meirong Li Qian Hou Qian Hou Qian Hou Lingzhi Zhong Lingzhi Zhong Lingzhi Zhong Yali Zhao Xiaobing Fu Xiaobing Fu Xiaobing Fu |
| author_facet | Meirong Li Meirong Li Meirong Li Meirong Li Qian Hou Qian Hou Qian Hou Lingzhi Zhong Lingzhi Zhong Lingzhi Zhong Yali Zhao Xiaobing Fu Xiaobing Fu Xiaobing Fu |
| author_sort | Meirong Li |
| collection | DOAJ |
| description | Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic wounds, and macrophage malfunction is considered as a major contributor thereof. In this review, we describe the origin and heterogeneity of macrophages during wound healing, and compare macrophage function in healing and non-healing wounds. We consider extrinsic and intrinsic factors driving wound macrophage dysregulation, and review systemic and topical therapeutic approaches for the restoration of macrophage response. Multidimensional analysis is highlighted through the integration of various high-throughput technologies, used to assess the diversity and activation states as well as cellular communication of macrophages in healing and non-healing wound. This research fills the gaps in current literature and provides the promising therapeutic interventions for chronic wounds. |
| first_indexed | 2024-12-17T07:29:42Z |
| format | Article |
| id | doaj.art-4d7ecbfcdecf4c28a2e940a3e4620355 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-17T07:29:42Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-4d7ecbfcdecf4c28a2e940a3e46203552022-12-21T21:58:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-06-011210.3389/fimmu.2021.681710681710Macrophage Related Chronic Inflammation in Non-Healing WoundsMeirong Li0Meirong Li1Meirong Li2Meirong Li3Qian Hou4Qian Hou5Qian Hou6Lingzhi Zhong7Lingzhi Zhong8Lingzhi Zhong9Yali Zhao10Xiaobing Fu11Xiaobing Fu12Xiaobing Fu13Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center, PLA General Hospital and PLA Medical College, Beijing, ChinaPLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, PLA General Hospital, Beijing, ChinaResearch Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, Beijing, ChinaCentral Laboratory, Trauma Treatment Center, Central Laboratory, Chinese PLA General Hospital, Hainan Hospital, Sanya, ChinaResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center, PLA General Hospital and PLA Medical College, Beijing, ChinaPLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, PLA General Hospital, Beijing, ChinaResearch Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, Beijing, ChinaResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center, PLA General Hospital and PLA Medical College, Beijing, ChinaPLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, PLA General Hospital, Beijing, ChinaResearch Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, Beijing, ChinaCentral Laboratory, Trauma Treatment Center, Central Laboratory, Chinese PLA General Hospital, Hainan Hospital, Sanya, ChinaResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center, PLA General Hospital and PLA Medical College, Beijing, ChinaPLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, PLA General Hospital, Beijing, ChinaResearch Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, Beijing, ChinaPersistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic wounds, and macrophage malfunction is considered as a major contributor thereof. In this review, we describe the origin and heterogeneity of macrophages during wound healing, and compare macrophage function in healing and non-healing wounds. We consider extrinsic and intrinsic factors driving wound macrophage dysregulation, and review systemic and topical therapeutic approaches for the restoration of macrophage response. Multidimensional analysis is highlighted through the integration of various high-throughput technologies, used to assess the diversity and activation states as well as cellular communication of macrophages in healing and non-healing wound. This research fills the gaps in current literature and provides the promising therapeutic interventions for chronic wounds.https://www.frontiersin.org/articles/10.3389/fimmu.2021.681710/fullchronic inflammationchronic woundmacrophageheterogeneityagingdiabetes |
| spellingShingle | Meirong Li Meirong Li Meirong Li Meirong Li Qian Hou Qian Hou Qian Hou Lingzhi Zhong Lingzhi Zhong Lingzhi Zhong Yali Zhao Xiaobing Fu Xiaobing Fu Xiaobing Fu Macrophage Related Chronic Inflammation in Non-Healing Wounds Frontiers in Immunology chronic inflammation chronic wound macrophage heterogeneity aging diabetes |
| title | Macrophage Related Chronic Inflammation in Non-Healing Wounds |
| title_full | Macrophage Related Chronic Inflammation in Non-Healing Wounds |
| title_fullStr | Macrophage Related Chronic Inflammation in Non-Healing Wounds |
| title_full_unstemmed | Macrophage Related Chronic Inflammation in Non-Healing Wounds |
| title_short | Macrophage Related Chronic Inflammation in Non-Healing Wounds |
| title_sort | macrophage related chronic inflammation in non healing wounds |
| topic | chronic inflammation chronic wound macrophage heterogeneity aging diabetes |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.681710/full |
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