KAP1 phosphorylation promotes the survival of neural stem cells after ischemia/reperfusion by maintaining the stability of PCNA

KAP1 phosphorylation promotes the survival of neural stem cells after ischemia/reperfusion by maintaining the stability of PCNA

Abstract Aims To explore the function of phosphorylation of KAP1 (p-KAP1) at the serine-824 site (S824) in the proliferation and apoptosis of endogenous neural stem cells (NSCs) after cerebral ischemic/reperfusion (I/R). Methods The apoptosis and proliferation of C17.2 cells transfected with the p-K...

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Bibliographic Details
Main Authors: Wan Wang, Tianqing Yan, Xinjian Guo, Heng Cai, Chang Liang, Linyan Huang, Yanling Wang, Ping Ma, Suhua Qi
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Stem Cell Research & Therapy
Subjects:
Cerebral ischemia/reperfusion (I/R)
Neural stem cells (NSCs)
Proliferation
KRAB domain protein 1(KAP1)
PCNA
Online Access:https://doi.org/10.1186/s13287-022-02962-5

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