Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging
Abstract Recently, few noninvasive methods have been reported to evaluate endometrial fibrosis. Our study was to investigate the feasibility of intravoxel incoherent motion (IVIM) MR imaging in the detection of endometrial fibrosis in patients with intrauterine injury. 30 patients with hysteroscopy-...
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| Format: | Article |
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Nature Portfolio
2021-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-92383-w |
| _version_ | 1818400522404626432 |
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| author | Qing Hu Peipei Jiang Yongjing Feng Yan Xu Nan Zhou Weibo Chen Li Zhu Yali Hu Zhengyang Zhou |
| author_facet | Qing Hu Peipei Jiang Yongjing Feng Yan Xu Nan Zhou Weibo Chen Li Zhu Yali Hu Zhengyang Zhou |
| author_sort | Qing Hu |
| collection | DOAJ |
| description | Abstract Recently, few noninvasive methods have been reported to evaluate endometrial fibrosis. Our study was to investigate the feasibility of intravoxel incoherent motion (IVIM) MR imaging in the detection of endometrial fibrosis in patients with intrauterine injury. 30 patients with hysteroscopy-confirmed endometrial fibrosis and 28 healthy women were enrolled to undergo MR examination including the IVIM sequence. Endometrial thickness (ET); apparent diffusion coefficient (ADC); and IVIM parameters, including pure diffusion coefficient (D), pseudodiffusion coefficient (D*) and vascular fraction (f) were evaluated. A multivariable model combing ADC, D, and f values using binary logistic regression analysis was built to diagnose endometrial fibrosis. Endometrial fibrosis patients demonstrated lower endometrial ADC, D, f values and ET (all p < 0.05). The multivariable model, ADC, D, f values and ET performed well in diagnosing endometrial fibrosis with AUC of 0.979, 0.965, 0.920, 0.901 and 0.833, respectively. The multivariable model revealed a better diagnostic accuracy than D, f and ET (all p < 0.05). Although ADC achieved a better diagnostic value than ET (z = 2.082, p < 0.05), no difference in AUC was shown among ADC, D, and f (all p > 0.05); between ET and D (p > 0.05); and between ET and f (p > 0.05). The reproducibility of ADC, D, f and D* values in patients with endometrial fibrosis and healthy women were good to excellent (ICC: 0.614–0.951). IVIM parameters exhibit promising potential to serve as imaging biomarkers in the noninvasive assessment of endometrial fibrosis. |
| first_indexed | 2024-12-14T07:37:55Z |
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| id | doaj.art-4d7f1141e1d14d6696721c4c4dcad73a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T07:37:55Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4d7f1141e1d14d6696721c4c4dcad73a2022-12-21T23:11:08ZengNature PortfolioScientific Reports2045-23222021-06-011111810.1038/s41598-021-92383-wNoninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imagingQing Hu0Peipei Jiang1Yongjing Feng2Yan Xu3Nan Zhou4Weibo Chen5Li Zhu6Yali Hu7Zhengyang Zhou8Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolDepartment of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolDepartment of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolDepartment of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolDepartment of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolPhilips HealthcareDepartment of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolDepartment of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolDepartment of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolAbstract Recently, few noninvasive methods have been reported to evaluate endometrial fibrosis. Our study was to investigate the feasibility of intravoxel incoherent motion (IVIM) MR imaging in the detection of endometrial fibrosis in patients with intrauterine injury. 30 patients with hysteroscopy-confirmed endometrial fibrosis and 28 healthy women were enrolled to undergo MR examination including the IVIM sequence. Endometrial thickness (ET); apparent diffusion coefficient (ADC); and IVIM parameters, including pure diffusion coefficient (D), pseudodiffusion coefficient (D*) and vascular fraction (f) were evaluated. A multivariable model combing ADC, D, and f values using binary logistic regression analysis was built to diagnose endometrial fibrosis. Endometrial fibrosis patients demonstrated lower endometrial ADC, D, f values and ET (all p < 0.05). The multivariable model, ADC, D, f values and ET performed well in diagnosing endometrial fibrosis with AUC of 0.979, 0.965, 0.920, 0.901 and 0.833, respectively. The multivariable model revealed a better diagnostic accuracy than D, f and ET (all p < 0.05). Although ADC achieved a better diagnostic value than ET (z = 2.082, p < 0.05), no difference in AUC was shown among ADC, D, and f (all p > 0.05); between ET and D (p > 0.05); and between ET and f (p > 0.05). The reproducibility of ADC, D, f and D* values in patients with endometrial fibrosis and healthy women were good to excellent (ICC: 0.614–0.951). IVIM parameters exhibit promising potential to serve as imaging biomarkers in the noninvasive assessment of endometrial fibrosis.https://doi.org/10.1038/s41598-021-92383-w |
| spellingShingle | Qing Hu Peipei Jiang Yongjing Feng Yan Xu Nan Zhou Weibo Chen Li Zhu Yali Hu Zhengyang Zhou Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging Scientific Reports |
| title | Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging |
| title_full | Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging |
| title_fullStr | Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging |
| title_full_unstemmed | Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging |
| title_short | Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging |
| title_sort | noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion mr imaging |
| url | https://doi.org/10.1038/s41598-021-92383-w |
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