A Subset of Non-Small Cell Lung Cancer Patients Treated with Pemetrexed Show <sup>18</sup>F-Fluorothymidine “Flare” on Positron Emission Tomography

A Subset of Non-Small Cell Lung Cancer Patients Treated with Pemetrexed Show <sup>18</sup>F-Fluorothymidine “Flare” on Positron Emission Tomography

Thymidylate synthase (TS) remains a major target for cancer therapy. TS inhibition elicits increases in DNA salvage pathway activity, detected as a transient compensatory “flare” in 3′-deoxy-3′-[<sup>18</sup>F]fluorothymidine positron emission tomography (<sup>18</sup>F-FLT P...

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Bibliographic Details
Main Authors: Preetha Aravind, Sanjay Popat, Tara D. Barwick, Neil Soneji, Mark Lythgoe, Katherina B. Sreter, Jingky P. Lozano-Kuehne, Mattias Bergqvist, Neva Patel, Eric O. Aboagye, Laura M. Kenny
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cancers
Subjects:
NSCLC
<sup>18</sup>F-FLT
PET
pemetrexed
thymidine kinase
Online Access:https://www.mdpi.com/2072-6694/15/14/3718

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