Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci

Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci

Glucocorticoids act by binding to the glucocorticoid receptor (GR), which binds to specific motifs within enhancers of target genes to activate transcription. Previous studies have suggested that GRs can promote interactions between gene promoters and distal elements within target loci. In contrast,...

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Bibliographic Details
Main Authors: Alasdair W. Jubb, Shelagh Boyle, David A. Hume, Wendy A. Bickmore
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Subjects:
chromatin remodeling
fluorescence in situ hybridization
glucocorticoid receptor
macrophage
enhancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717317059

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