Resveratrol‐loaded nanomedicines for cancer applications
Abstract Background Resveratrol (3, 5, 4′‐trihydroxystilbene), a natural polyphenol and phytoalexin, has drawn considerable attention in the past decade due to its wide variety of therapeutic activities such as anticancer, anti‐inflammatory, and antioxidant properties. However, its poor water solubi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-06-01
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| Series: | Cancer Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cnr2.1353 |
| _version_ | 1818669219115433984 |
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| author | Manjusha Annaji Ishwor Poudel Sai H. S. Boddu Robert D. Arnold Amit K. Tiwari R. Jayachandra Babu |
| author_facet | Manjusha Annaji Ishwor Poudel Sai H. S. Boddu Robert D. Arnold Amit K. Tiwari R. Jayachandra Babu |
| author_sort | Manjusha Annaji |
| collection | DOAJ |
| description | Abstract Background Resveratrol (3, 5, 4′‐trihydroxystilbene), a natural polyphenol and phytoalexin, has drawn considerable attention in the past decade due to its wide variety of therapeutic activities such as anticancer, anti‐inflammatory, and antioxidant properties. However, its poor water solubility, low chemical stability, and short biological half‐life limit its clinical utility. Recent findings Nanoparticles overcome the limitations associated with conventional chemotherapeutic drugs, such as limited availability of drugs to the tumor tissues, high systemic exposures, and consequent toxicity to healthy tissues. This review focuses on the physicochemical properties of resveratrol, the therapeutic potential of resveratrol nano‐formulations, and the anticancer activity of resveratrol encapsulated nanoparticles on various malignancies such as skin, breast, prostate, colon, liver, ovarian, and lung cancers (focusing on both in vitro and in vivo studies). Conclusions Nanotechnology approaches have been extensively utilized to achieve higher solubility, improved oral bioavailability, enhanced stability, and controlled release of resveratrol. The resveratrol nanoparticles have markedly enhanced its anticancer activity both in vitro and in vivo, thus considering it as a potential strategy to fight various cancers. |
| first_indexed | 2024-12-17T06:48:44Z |
| format | Article |
| id | doaj.art-4d80c3d7e08947db80794ebe90d60426 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-12-17T06:48:44Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-4d80c3d7e08947db80794ebe90d604262022-12-21T21:59:39ZengWileyCancer Reports2573-83482021-06-0143n/an/a10.1002/cnr2.1353Resveratrol‐loaded nanomedicines for cancer applicationsManjusha Annaji0Ishwor Poudel1Sai H. S. Boddu2Robert D. Arnold3Amit K. Tiwari4R. Jayachandra Babu5Department of Drug Discovery and Development Auburn University Auburn Alabama USADepartment of Drug Discovery and Development Auburn University Auburn Alabama USADepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences Ajman University Ajman United Arab EmiratesDepartment of Drug Discovery and Development Auburn University Auburn Alabama USADepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences University of Toledo Toledo Ohio USADepartment of Drug Discovery and Development Auburn University Auburn Alabama USAAbstract Background Resveratrol (3, 5, 4′‐trihydroxystilbene), a natural polyphenol and phytoalexin, has drawn considerable attention in the past decade due to its wide variety of therapeutic activities such as anticancer, anti‐inflammatory, and antioxidant properties. However, its poor water solubility, low chemical stability, and short biological half‐life limit its clinical utility. Recent findings Nanoparticles overcome the limitations associated with conventional chemotherapeutic drugs, such as limited availability of drugs to the tumor tissues, high systemic exposures, and consequent toxicity to healthy tissues. This review focuses on the physicochemical properties of resveratrol, the therapeutic potential of resveratrol nano‐formulations, and the anticancer activity of resveratrol encapsulated nanoparticles on various malignancies such as skin, breast, prostate, colon, liver, ovarian, and lung cancers (focusing on both in vitro and in vivo studies). Conclusions Nanotechnology approaches have been extensively utilized to achieve higher solubility, improved oral bioavailability, enhanced stability, and controlled release of resveratrol. The resveratrol nanoparticles have markedly enhanced its anticancer activity both in vitro and in vivo, thus considering it as a potential strategy to fight various cancers.https://doi.org/10.1002/cnr2.1353cancerin vitroin vivonanoparticlespolyphenolresveratrol |
| spellingShingle | Manjusha Annaji Ishwor Poudel Sai H. S. Boddu Robert D. Arnold Amit K. Tiwari R. Jayachandra Babu Resveratrol‐loaded nanomedicines for cancer applications Cancer Reports cancer in vitro in vivo nanoparticles polyphenol resveratrol |
| title | Resveratrol‐loaded nanomedicines for cancer applications |
| title_full | Resveratrol‐loaded nanomedicines for cancer applications |
| title_fullStr | Resveratrol‐loaded nanomedicines for cancer applications |
| title_full_unstemmed | Resveratrol‐loaded nanomedicines for cancer applications |
| title_short | Resveratrol‐loaded nanomedicines for cancer applications |
| title_sort | resveratrol loaded nanomedicines for cancer applications |
| topic | cancer in vitro in vivo nanoparticles polyphenol resveratrol |
| url | https://doi.org/10.1002/cnr2.1353 |
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