Positive expiratory pressure improves oxygenation in healthy subjects exposed to hypoxia.
Positive end-expiratory pressure (PEEP) is commonly used in critical care medicine to improve gas exchange. Altitude sickness is associated with exaggerated reduction in arterial oxygenation. We assessed the effect of PEEP and pursed lips breathing (PLB) on arterial and tissue oxygenation under norm...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3871630?pdf=render |
| _version_ | 1811209473066270720 |
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| author | Hugo Nespoulet Thomas Rupp Damien Bachasson Renaud Tamisier Bernard Wuyam Patrick Lévy Samuel Verges |
| author_facet | Hugo Nespoulet Thomas Rupp Damien Bachasson Renaud Tamisier Bernard Wuyam Patrick Lévy Samuel Verges |
| author_sort | Hugo Nespoulet |
| collection | DOAJ |
| description | Positive end-expiratory pressure (PEEP) is commonly used in critical care medicine to improve gas exchange. Altitude sickness is associated with exaggerated reduction in arterial oxygenation. We assessed the effect of PEEP and pursed lips breathing (PLB) on arterial and tissue oxygenation under normobaric and hypobaric hypoxic conditions.Sixteen healthy volunteers were exposed to acute normobaric hypoxia (Laboratory study, FiO₂=0.12). The protocol consisted in 3-min phases with PEEPs of 0, 5 or 10 cmH₂O, PLB or similar ventilation than with PEEP-10, interspaced with 3-min phases of free breathing. Arterial (pulse oximetry) and quadriceps (near-infrared spectroscopy) oxygenation, ventilation, cardiac function, esophageal and gastric pressures and subjects' subjective perceptions were recorded continuously. In addition, the effect of PEEP on arterial oxygenation was tested at 4,350 m of altitude in 9 volunteers breathing for 20 min with PEEP-10 (Field study).During the laboratory study, PEEP-10 increased arterial and quadriceps oxygenation (arterial oxygen saturation +5.6±5.0% and quadriceps oxyhemoglobin +58±73 µmol.cm compared to free breathing; p<0.05). Conversely, PLB did not increase oxygenation. Oxygenation improvement with PEEP-10 was accompanied by an increase in expiratory esophageal and gastric pressures (esophageal pressure swing +5.4±3.2 cmH₂O, p<0.05) but no change in minute ventilation, breathing pattern, end-tidal CO₂ or cardiac function (all p>0.05) compared to PEEP-0. During the field study, PEEP-10 increased arterial oxygen saturation by +6.7±6.0% after the 3(rd) minute with PEEP-10 without further significant increase until the 20(th) minute with PEEP-10. Subjects did not report any significant discomfort with PEEP.These data indicate that 10-cmH₂O PEEP significantly improves arterial and muscle oxygenation under both normobaric and hypobaric hypoxic conditions in healthy subjects. PEEP-10 could be an attractive non-pharmacological tool to limit blood oxygen desaturation and possibly symptoms at altitude. |
| first_indexed | 2024-04-12T04:38:46Z |
| format | Article |
| id | doaj.art-4d80de75c99742fe8dd7351d8bc5bff8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T04:38:46Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4d80de75c99742fe8dd7351d8bc5bff82022-12-22T03:47:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8521910.1371/journal.pone.0085219Positive expiratory pressure improves oxygenation in healthy subjects exposed to hypoxia.Hugo NespouletThomas RuppDamien BachassonRenaud TamisierBernard WuyamPatrick LévySamuel VergesPositive end-expiratory pressure (PEEP) is commonly used in critical care medicine to improve gas exchange. Altitude sickness is associated with exaggerated reduction in arterial oxygenation. We assessed the effect of PEEP and pursed lips breathing (PLB) on arterial and tissue oxygenation under normobaric and hypobaric hypoxic conditions.Sixteen healthy volunteers were exposed to acute normobaric hypoxia (Laboratory study, FiO₂=0.12). The protocol consisted in 3-min phases with PEEPs of 0, 5 or 10 cmH₂O, PLB or similar ventilation than with PEEP-10, interspaced with 3-min phases of free breathing. Arterial (pulse oximetry) and quadriceps (near-infrared spectroscopy) oxygenation, ventilation, cardiac function, esophageal and gastric pressures and subjects' subjective perceptions were recorded continuously. In addition, the effect of PEEP on arterial oxygenation was tested at 4,350 m of altitude in 9 volunteers breathing for 20 min with PEEP-10 (Field study).During the laboratory study, PEEP-10 increased arterial and quadriceps oxygenation (arterial oxygen saturation +5.6±5.0% and quadriceps oxyhemoglobin +58±73 µmol.cm compared to free breathing; p<0.05). Conversely, PLB did not increase oxygenation. Oxygenation improvement with PEEP-10 was accompanied by an increase in expiratory esophageal and gastric pressures (esophageal pressure swing +5.4±3.2 cmH₂O, p<0.05) but no change in minute ventilation, breathing pattern, end-tidal CO₂ or cardiac function (all p>0.05) compared to PEEP-0. During the field study, PEEP-10 increased arterial oxygen saturation by +6.7±6.0% after the 3(rd) minute with PEEP-10 without further significant increase until the 20(th) minute with PEEP-10. Subjects did not report any significant discomfort with PEEP.These data indicate that 10-cmH₂O PEEP significantly improves arterial and muscle oxygenation under both normobaric and hypobaric hypoxic conditions in healthy subjects. PEEP-10 could be an attractive non-pharmacological tool to limit blood oxygen desaturation and possibly symptoms at altitude.http://europepmc.org/articles/PMC3871630?pdf=render |
| spellingShingle | Hugo Nespoulet Thomas Rupp Damien Bachasson Renaud Tamisier Bernard Wuyam Patrick Lévy Samuel Verges Positive expiratory pressure improves oxygenation in healthy subjects exposed to hypoxia. PLoS ONE |
| title | Positive expiratory pressure improves oxygenation in healthy subjects exposed to hypoxia. |
| title_full | Positive expiratory pressure improves oxygenation in healthy subjects exposed to hypoxia. |
| title_fullStr | Positive expiratory pressure improves oxygenation in healthy subjects exposed to hypoxia. |
| title_full_unstemmed | Positive expiratory pressure improves oxygenation in healthy subjects exposed to hypoxia. |
| title_short | Positive expiratory pressure improves oxygenation in healthy subjects exposed to hypoxia. |
| title_sort | positive expiratory pressure improves oxygenation in healthy subjects exposed to hypoxia |
| url | http://europepmc.org/articles/PMC3871630?pdf=render |
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