The role of α1- and α2-adrenoceptor subtypes in the vasopressor responses induced by dihydroergotamine in ritanserin-pretreated pithed rats

The role of α1- and α2-adrenoceptor subtypes in the vasopressor responses induced by dihydroergotamine in ritanserin-pretreated pithed rats

Abstract Background Dihydroergotamine (DHE) is an acute antimigraine agent that displays affinity for dopamine D2-like receptors, serotonin 5-HT1/2 receptors and α1/α2-adrenoceptors. Since activation of vascular α1/α2-adrenoceptors results in systemic vasopressor responses, the purpose of this study...

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Bibliographic Details
Main Authors: Eduardo Rivera-Mancilla, Victor H. Avilés-Rosas, Guadalupe Manrique-Maldonado, Alain H. Altamirano-Espinoza, Belinda Villanueva-Castillo, Antoinette MaassenVanDenBrink, Carlos M. Villalón
Format: Article
Language:English
Published: BMC 2017-10-01
Series:The Journal of Headache and Pain
Subjects:
α-Adrenoceptors
Dihydroergotamine
Pithed rat
Ritanserin
Vasopressor responses
Online Access:http://link.springer.com/article/10.1186/s10194-017-0812-4

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