Amelioration of Alcohol Induced Gastric Ulcers Through the Administration of Lactobacillus plantarum APSulloc 331261 Isolated From Green Tea
Gastric inflammation is an indication of gastric ulcers and possible other underlying gastric malignancies. Epidemiological studies have revealed that several Asian countries, including South Korea, suffer from a high incidence of gastric diseases derived from high levels of stress, alcoholic consum...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-03-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2020.00420/full |
| _version_ | 1818479592602599424 |
|---|---|
| author | Haryung Park Donghyun Cho Eunchong Huang Ju Yeon Seo Wan Gi Kim Svetoslav Dimitrov Todorov Yosep Ji Wilhelm Heinrich Holzapfel |
| author_facet | Haryung Park Donghyun Cho Eunchong Huang Ju Yeon Seo Wan Gi Kim Svetoslav Dimitrov Todorov Yosep Ji Wilhelm Heinrich Holzapfel |
| author_sort | Haryung Park |
| collection | DOAJ |
| description | Gastric inflammation is an indication of gastric ulcers and possible other underlying gastric malignancies. Epidemiological studies have revealed that several Asian countries, including South Korea, suffer from a high incidence of gastric diseases derived from high levels of stress, alcoholic consumption, pyloric infection and usage of non-steroidal anti-inflammatory drugs (NSAIDs). Clinical treatments of gastric ulcers are generally limited to proton pump inhibitors that neutralize the stomach acid, and the application of antibiotics for Helicobacter pylori eradication, both of which are known to have a negative effect on the gut microbiota. The potential of probiotics for alleviating gastrointestinal diseases such as intestinal bowel syndrome and intestinal bowel disease receives increasing scientific interest. Probiotics may support the amelioration of disease-related symptoms through modulation of the gut microbiota without causing dysbiosis. In this study the potential of Lactobacillus plantarum APSulloc 331261 (GTB1TM), isolated from green tea, was investigated for alleviating gastric inflammation in an alcohol induced gastric ulcer murine model (positive control). Treatment with the test strain significantly influenced the expression of pro-inflammatory and anti-inflammatory biomarkers, interleukin 6 (IL6) and interleukin 10 (IL10), of which the former was down- and the latter up-regulated when the alcohol induced mice were treated with the test strain. This positive effect was also indicated by less severe gastric morphological changes and the histological score of the gastric tissues. A significant increase in the abundance of Akkermansia within the GTB1TM treated group compared to the positive control group also correlated with a decrease in the ratio of acetate over propionate. The increased levels of propionate in the GTB1TM group appear to result from the impact of the test strain on the microbial population and the resulting metabolic activities. Moreover, there was a significant increase in beta-diversity in the group that received GTB1TM over that of the alcohol induced control group. |
| first_indexed | 2024-12-10T11:12:48Z |
| format | Article |
| id | doaj.art-4d84940da9894528be535c4ba16309ef |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-10T11:12:48Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-4d84940da9894528be535c4ba16309ef2022-12-22T01:51:20ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2020-03-011110.3389/fmicb.2020.00420512298Amelioration of Alcohol Induced Gastric Ulcers Through the Administration of Lactobacillus plantarum APSulloc 331261 Isolated From Green TeaHaryung Park0Donghyun Cho1Eunchong Huang2Ju Yeon Seo3Wan Gi Kim4Svetoslav Dimitrov Todorov5Yosep Ji6Wilhelm Heinrich Holzapfel7Advanced Green Energy and Environment Institute (AGEE), Handong Global University, Pohang, South KoreaVital Beautie Research Division, Amore Pacific R&D Unit, Gyeonggi-do, South KoreaAdvanced Green Energy and Environment Institute (AGEE), Handong Global University, Pohang, South KoreaVital Beautie Research Division, Amore Pacific R&D Unit, Gyeonggi-do, South KoreaVital Beautie Research Division, Amore Pacific R&D Unit, Gyeonggi-do, South KoreaAdvanced Green Energy and Environment Institute (AGEE), Handong Global University, Pohang, South KoreaAdvanced Green Energy and Environment Institute (AGEE), Handong Global University, Pohang, South KoreaAdvanced Green Energy and Environment Institute (AGEE), Handong Global University, Pohang, South KoreaGastric inflammation is an indication of gastric ulcers and possible other underlying gastric malignancies. Epidemiological studies have revealed that several Asian countries, including South Korea, suffer from a high incidence of gastric diseases derived from high levels of stress, alcoholic consumption, pyloric infection and usage of non-steroidal anti-inflammatory drugs (NSAIDs). Clinical treatments of gastric ulcers are generally limited to proton pump inhibitors that neutralize the stomach acid, and the application of antibiotics for Helicobacter pylori eradication, both of which are known to have a negative effect on the gut microbiota. The potential of probiotics for alleviating gastrointestinal diseases such as intestinal bowel syndrome and intestinal bowel disease receives increasing scientific interest. Probiotics may support the amelioration of disease-related symptoms through modulation of the gut microbiota without causing dysbiosis. In this study the potential of Lactobacillus plantarum APSulloc 331261 (GTB1TM), isolated from green tea, was investigated for alleviating gastric inflammation in an alcohol induced gastric ulcer murine model (positive control). Treatment with the test strain significantly influenced the expression of pro-inflammatory and anti-inflammatory biomarkers, interleukin 6 (IL6) and interleukin 10 (IL10), of which the former was down- and the latter up-regulated when the alcohol induced mice were treated with the test strain. This positive effect was also indicated by less severe gastric morphological changes and the histological score of the gastric tissues. A significant increase in the abundance of Akkermansia within the GTB1TM treated group compared to the positive control group also correlated with a decrease in the ratio of acetate over propionate. The increased levels of propionate in the GTB1TM group appear to result from the impact of the test strain on the microbial population and the resulting metabolic activities. Moreover, there was a significant increase in beta-diversity in the group that received GTB1TM over that of the alcohol induced control group.https://www.frontiersin.org/article/10.3389/fmicb.2020.00420/fullalcohol induced gastric ulcersLactobacillus plantarumshort chain fatty acidsgut microbiomeAkkermansia |
| spellingShingle | Haryung Park Donghyun Cho Eunchong Huang Ju Yeon Seo Wan Gi Kim Svetoslav Dimitrov Todorov Yosep Ji Wilhelm Heinrich Holzapfel Amelioration of Alcohol Induced Gastric Ulcers Through the Administration of Lactobacillus plantarum APSulloc 331261 Isolated From Green Tea Frontiers in Microbiology alcohol induced gastric ulcers Lactobacillus plantarum short chain fatty acids gut microbiome Akkermansia |
| title | Amelioration of Alcohol Induced Gastric Ulcers Through the Administration of Lactobacillus plantarum APSulloc 331261 Isolated From Green Tea |
| title_full | Amelioration of Alcohol Induced Gastric Ulcers Through the Administration of Lactobacillus plantarum APSulloc 331261 Isolated From Green Tea |
| title_fullStr | Amelioration of Alcohol Induced Gastric Ulcers Through the Administration of Lactobacillus plantarum APSulloc 331261 Isolated From Green Tea |
| title_full_unstemmed | Amelioration of Alcohol Induced Gastric Ulcers Through the Administration of Lactobacillus plantarum APSulloc 331261 Isolated From Green Tea |
| title_short | Amelioration of Alcohol Induced Gastric Ulcers Through the Administration of Lactobacillus plantarum APSulloc 331261 Isolated From Green Tea |
| title_sort | amelioration of alcohol induced gastric ulcers through the administration of lactobacillus plantarum apsulloc 331261 isolated from green tea |
| topic | alcohol induced gastric ulcers Lactobacillus plantarum short chain fatty acids gut microbiome Akkermansia |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2020.00420/full |
| work_keys_str_mv | AT haryungpark ameliorationofalcoholinducedgastriculcersthroughtheadministrationoflactobacillusplantarumapsulloc331261isolatedfromgreentea AT donghyuncho ameliorationofalcoholinducedgastriculcersthroughtheadministrationoflactobacillusplantarumapsulloc331261isolatedfromgreentea AT eunchonghuang ameliorationofalcoholinducedgastriculcersthroughtheadministrationoflactobacillusplantarumapsulloc331261isolatedfromgreentea AT juyeonseo ameliorationofalcoholinducedgastriculcersthroughtheadministrationoflactobacillusplantarumapsulloc331261isolatedfromgreentea AT wangikim ameliorationofalcoholinducedgastriculcersthroughtheadministrationoflactobacillusplantarumapsulloc331261isolatedfromgreentea AT svetoslavdimitrovtodorov ameliorationofalcoholinducedgastriculcersthroughtheadministrationoflactobacillusplantarumapsulloc331261isolatedfromgreentea AT yosepji ameliorationofalcoholinducedgastriculcersthroughtheadministrationoflactobacillusplantarumapsulloc331261isolatedfromgreentea AT wilhelmheinrichholzapfel ameliorationofalcoholinducedgastriculcersthroughtheadministrationoflactobacillusplantarumapsulloc331261isolatedfromgreentea |