Synthesis and antimicrobial activity of 4-(5-ARYL-2-FUROYL)morpholines and 4-[(5-ARYL-2-FURYL)carbonothioyl] morpholines
By the reaction of furan-2-carboxylic acids and furfural with diazonium salts 1a-j the arylfuran-2-carboxylic acids 4a-e and 5-arylfuran-2-carbaldehydes 5a-f were synthesized. Acids 4a-e were transformed into appropriated acylchlorides 6a-e and were used for preparation of 4-(5-aryl-2-furoyl)morphol...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2021-01-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/46942/download/pdf/ |
| _version_ | 1819049491903283200 |
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| author | Yuliia Matiichuk Yuri Gorak Roman Martyak Taras Chaban Volodymyr Ogurtsov Igor Chaban Vasyl Matiychuk |
| author_facet | Yuliia Matiichuk Yuri Gorak Roman Martyak Taras Chaban Volodymyr Ogurtsov Igor Chaban Vasyl Matiychuk |
| author_sort | Yuliia Matiichuk |
| collection | DOAJ |
| description | By the reaction of furan-2-carboxylic acids and furfural with diazonium salts 1a-j the arylfuran-2-carboxylic acids 4a-e and 5-arylfuran-2-carbaldehydes 5a-f were synthesized. Acids 4a-e were transformed into appropriated acylchlorides 6a-e and were used for preparation of 4-(5-aryl-2-furoyl)morpholines 7a-e. 4-[(5-Aryl-2-furyl)carbonothioyl]morpholines 8a-f were prepared from aldehydes 5a-f by using Willgerodt-Kindler reaction. The structures of the obtained compounds were confirmed by 1H NMR spectroscopy and elemental analysis. All these new compounds gave spectroscopic data in accordance with the proposed structures. The antimicrobial activities of synthesized compounds 7a-e and 8a-f were investigated and the compounds with high activity against C. neoformans ATCC 208821 were identified. |
| first_indexed | 2024-12-21T11:33:00Z |
| format | Article |
| id | doaj.art-4d84c7703c8a45d2bd8a2c13a918e584 |
| institution | Directory Open Access Journal |
| issn | 2603-557X |
| language | English |
| last_indexed | 2024-12-21T11:33:00Z |
| publishDate | 2021-01-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj.art-4d84c7703c8a45d2bd8a2c13a918e5842022-12-21T19:05:31ZengPensoft PublishersPharmacia2603-557X2021-01-0168117517910.3897/pharmacia.68.e4694246942Synthesis and antimicrobial activity of 4-(5-ARYL-2-FUROYL)morpholines and 4-[(5-ARYL-2-FURYL)carbonothioyl] morpholinesYuliia Matiichuk0Yuri Gorak1Roman Martyak2Taras Chaban3Volodymyr Ogurtsov4Igor Chaban5Vasyl Matiychuk6Danylo Halytsky Lviv National Medical UniversityIvan Franko National UniversityIvan Franko National UniversityDanylo Halytsky Lviv National Medical UniversityDanylo Halytsky Lviv National Medical UniversityDanylo Halytsky Lviv National Medical UniversityIvan Franko National UniversityBy the reaction of furan-2-carboxylic acids and furfural with diazonium salts 1a-j the arylfuran-2-carboxylic acids 4a-e and 5-arylfuran-2-carbaldehydes 5a-f were synthesized. Acids 4a-e were transformed into appropriated acylchlorides 6a-e and were used for preparation of 4-(5-aryl-2-furoyl)morpholines 7a-e. 4-[(5-Aryl-2-furyl)carbonothioyl]morpholines 8a-f were prepared from aldehydes 5a-f by using Willgerodt-Kindler reaction. The structures of the obtained compounds were confirmed by 1H NMR spectroscopy and elemental analysis. All these new compounds gave spectroscopic data in accordance with the proposed structures. The antimicrobial activities of synthesized compounds 7a-e and 8a-f were investigated and the compounds with high activity against C. neoformans ATCC 208821 were identified.https://pharmacia.pensoft.net/article/46942/download/pdf/ |
| spellingShingle | Yuliia Matiichuk Yuri Gorak Roman Martyak Taras Chaban Volodymyr Ogurtsov Igor Chaban Vasyl Matiychuk Synthesis and antimicrobial activity of 4-(5-ARYL-2-FUROYL)morpholines and 4-[(5-ARYL-2-FURYL)carbonothioyl] morpholines Pharmacia |
| title | Synthesis and antimicrobial activity of 4-(5-ARYL-2-FUROYL)morpholines and 4-[(5-ARYL-2-FURYL)carbonothioyl] morpholines |
| title_full | Synthesis and antimicrobial activity of 4-(5-ARYL-2-FUROYL)morpholines and 4-[(5-ARYL-2-FURYL)carbonothioyl] morpholines |
| title_fullStr | Synthesis and antimicrobial activity of 4-(5-ARYL-2-FUROYL)morpholines and 4-[(5-ARYL-2-FURYL)carbonothioyl] morpholines |
| title_full_unstemmed | Synthesis and antimicrobial activity of 4-(5-ARYL-2-FUROYL)morpholines and 4-[(5-ARYL-2-FURYL)carbonothioyl] morpholines |
| title_short | Synthesis and antimicrobial activity of 4-(5-ARYL-2-FUROYL)morpholines and 4-[(5-ARYL-2-FURYL)carbonothioyl] morpholines |
| title_sort | synthesis and antimicrobial activity of 4 5 aryl 2 furoyl morpholines and 4 5 aryl 2 furyl carbonothioyl morpholines |
| url | https://pharmacia.pensoft.net/article/46942/download/pdf/ |
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