Evaluating the Level of Serum IL-23 in Brucellosis Infection by ELISA and Investigating its Relationship in Cases with Failure to Respond to Treatment
Brucella is belonging to the small immobile gram-negative spore-lacking cocco-bacilli bacteria family that grows in an aerobic environment, it is known as a zoonosis infection named brucellosis. This study was designed to investigate serum values of IL-23 in patient with brucellosis and investigate...
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| Format: | Article |
| Language: | English |
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Razi Vaccine and Serum Research Institute
2022-06-01
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| Series: | Archives of Razi Institute |
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| Online Access: | https://archrazi.areeo.ac.ir/article_126765_429217d2fc896c1025e41f6c881f3b25.pdf |
| _version_ | 1828473763480469504 |
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| author | A Ihsan Rashan A Mahdi Rheima M Ghadhanfar Alwan M Abed Jawad H. T Mohammed M Gaber Abdel Razzaq A Ahmed Al-Taweel H Attia Thijail S Ahjel A Jalil Obaid |
| author_facet | A Ihsan Rashan A Mahdi Rheima M Ghadhanfar Alwan M Abed Jawad H. T Mohammed M Gaber Abdel Razzaq A Ahmed Al-Taweel H Attia Thijail S Ahjel A Jalil Obaid |
| author_sort | A Ihsan Rashan |
| collection | DOAJ |
| description | Brucella is belonging to the small immobile gram-negative spore-lacking cocco-bacilli bacteria family that grows in an aerobic environment, it is known as a zoonosis infection named brucellosis. This study was designed to investigate serum values of IL-23 in patient with brucellosis and investigate its relationship with cases with failure to respond to conventional medical therapy. A total of 372 individuals were divided into 2 groups (n=186) as follows: Group A comprising 186 infected participants with brucella (7-80 years-old), these people had not received antibiotics for at least 6 months ago. Group B including the healthy participants. All the participants in both groups were in the same age range. 5 ml blood samples were obtained from the participants intravenously (without anticoagulation substance). The serum level of IL-23 was investigated by ELISA diagnostic kit. The recorded data showed that the levels of IL-23 in the serum samples obtained from group A (143.64 Pg/ml) significantly (P<0.001) increased compared with this value in group B (23.14 Pg/ml). Based on the recorded data in the forms completed by all the participants at the day 0 of the experiment, 44 out of 186 individuals in group A, had experienced Brucellosis attack 2-3 times in spite of receiving medical prescriptions. A hypothesis about the possible immune system disorders in these participants lead us to did the re-sampling following drug administration. Results illustrated failure to respond to conventional medical therapy in patients with low level of serum IL-23. |
| first_indexed | 2024-12-11T05:49:36Z |
| format | Article |
| id | doaj.art-4d860734b4ae49ab8085028202a11a64 |
| institution | Directory Open Access Journal |
| issn | 0365-3439 2008-9872 |
| language | English |
| last_indexed | 2024-12-11T05:49:36Z |
| publishDate | 2022-06-01 |
| publisher | Razi Vaccine and Serum Research Institute |
| record_format | Article |
| series | Archives of Razi Institute |
| spelling | doaj.art-4d860734b4ae49ab8085028202a11a642022-12-22T01:18:51ZengRazi Vaccine and Serum Research InstituteArchives of Razi Institute0365-34392008-98722022-06-017731267127110.22092/ari.2022.358877.2324126765Evaluating the Level of Serum IL-23 in Brucellosis Infection by ELISA and Investigating its Relationship in Cases with Failure to Respond to TreatmentA Ihsan Rashan0A Mahdi Rheima1M Ghadhanfar Alwan2M Abed Jawad3H. T Mohammed4M Gaber Abdel Razzaq5A Ahmed Al-Taweel6H Attia Thijail7S Ahjel8A Jalil Obaid9Department of Pharmacy, Al-Hadba University College, Mosul, IraqCollege of technical engineering, The Islamic University, Najaf, IraqMedical laboratory techniques Department, Medical (Technology) College, Al-Farahidi University, Baghdad, IraqAl-Nisour University College, Baghdad, IraqAnesthesia Techniques Department, Al-Mustaqbal University College, Babylon, IraqAl-Manara College For Medical Sciences, Misan, IraqAl-Esraa University College, Baghdad, IraqCollege of Health and Medical Technology, Al-Ayen University, Thi-Qar, IraqDepartment of Pharmacy, Al-Zahrawi University College, Karbala, IraqMedical Laboratory Techniques Department, Hilla University College, Babylon, IraqBrucella is belonging to the small immobile gram-negative spore-lacking cocco-bacilli bacteria family that grows in an aerobic environment, it is known as a zoonosis infection named brucellosis. This study was designed to investigate serum values of IL-23 in patient with brucellosis and investigate its relationship with cases with failure to respond to conventional medical therapy. A total of 372 individuals were divided into 2 groups (n=186) as follows: Group A comprising 186 infected participants with brucella (7-80 years-old), these people had not received antibiotics for at least 6 months ago. Group B including the healthy participants. All the participants in both groups were in the same age range. 5 ml blood samples were obtained from the participants intravenously (without anticoagulation substance). The serum level of IL-23 was investigated by ELISA diagnostic kit. The recorded data showed that the levels of IL-23 in the serum samples obtained from group A (143.64 Pg/ml) significantly (P<0.001) increased compared with this value in group B (23.14 Pg/ml). Based on the recorded data in the forms completed by all the participants at the day 0 of the experiment, 44 out of 186 individuals in group A, had experienced Brucellosis attack 2-3 times in spite of receiving medical prescriptions. A hypothesis about the possible immune system disorders in these participants lead us to did the re-sampling following drug administration. Results illustrated failure to respond to conventional medical therapy in patients with low level of serum IL-23.https://archrazi.areeo.ac.ir/article_126765_429217d2fc896c1025e41f6c881f3b25.pdfil-23serum valuebrucellosismedical therapy |
| spellingShingle | A Ihsan Rashan A Mahdi Rheima M Ghadhanfar Alwan M Abed Jawad H. T Mohammed M Gaber Abdel Razzaq A Ahmed Al-Taweel H Attia Thijail S Ahjel A Jalil Obaid Evaluating the Level of Serum IL-23 in Brucellosis Infection by ELISA and Investigating its Relationship in Cases with Failure to Respond to Treatment Archives of Razi Institute il-23 serum value brucellosis medical therapy |
| title | Evaluating the Level of Serum IL-23 in Brucellosis Infection by ELISA and Investigating its Relationship in Cases with Failure to Respond to Treatment |
| title_full | Evaluating the Level of Serum IL-23 in Brucellosis Infection by ELISA and Investigating its Relationship in Cases with Failure to Respond to Treatment |
| title_fullStr | Evaluating the Level of Serum IL-23 in Brucellosis Infection by ELISA and Investigating its Relationship in Cases with Failure to Respond to Treatment |
| title_full_unstemmed | Evaluating the Level of Serum IL-23 in Brucellosis Infection by ELISA and Investigating its Relationship in Cases with Failure to Respond to Treatment |
| title_short | Evaluating the Level of Serum IL-23 in Brucellosis Infection by ELISA and Investigating its Relationship in Cases with Failure to Respond to Treatment |
| title_sort | evaluating the level of serum il 23 in brucellosis infection by elisa and investigating its relationship in cases with failure to respond to treatment |
| topic | il-23 serum value brucellosis medical therapy |
| url | https://archrazi.areeo.ac.ir/article_126765_429217d2fc896c1025e41f6c881f3b25.pdf |
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