The role of probiotics in the immune response and intestinal microbiota of children with celiac disease: a systematic review
ABSTRACT Objective: To evaluate changes in peripheral immunological response (decrease in blood proinflammatory cytokines) and fecal microbiota (especially Bacteroidetes and Firmicutes) after administration of probiotics in children with celiac disease on a gluten-free diet. Data source: The datab...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade de Pediatria de São Paulo
|
| Series: | Revista Paulista de Pediatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822022000100508&tlng=pt |
| _version_ | 1811271409648795648 |
|---|---|
| author | Camila Fernanda Jedwab Bruna Cardoso de Mattos Boccalini Roston Ana Beatriz Ferreira de Souza Toge Isadora Fagundes Echeverria Guilherme Ojea Gomes Tavares Matheus Alves Alvares Vera Esteves Vagnozzi Rullo Marcella Rocha Machado de Oliveira |
| author_facet | Camila Fernanda Jedwab Bruna Cardoso de Mattos Boccalini Roston Ana Beatriz Ferreira de Souza Toge Isadora Fagundes Echeverria Guilherme Ojea Gomes Tavares Matheus Alves Alvares Vera Esteves Vagnozzi Rullo Marcella Rocha Machado de Oliveira |
| author_sort | Camila Fernanda Jedwab |
| collection | DOAJ |
| description | ABSTRACT Objective: To evaluate changes in peripheral immunological response (decrease in blood proinflammatory cytokines) and fecal microbiota (especially Bacteroidetes and Firmicutes) after administration of probiotics in children with celiac disease on a gluten-free diet. Data source: The databases MEDLINE, LILACS, Springer and SciELO were used for this review, with the descriptors “celiac disease AND probiotics”. At the end of the search, 168 articles were retrieved, four of which were included in the final qualitative synthesis, having as inclusion criteria randomized clinical trials and pediatric population (1–19 years) and, as exclusion criteria, interventions other than probiotics, studies with patients with other diseases associated with celiac disease, or patients who did not meet the diagnostic criteria. All elected studies were published until September 2020, without language restriction, with patients receiving strains of Bifidobacterium breve or B. longum and on a gluten-free diet. Data synthesis: The studies show that the administration of probiotics along with a gluten-free diet, can approximate the fecal microbiota of celiac patients to typical conditions of healthy individuals, by restoring the abundance of some microbial communities that characterize the typical physiological condition. In addition, the administration of probiotics can reduce serum proinflammatory cytokines (mainly TNF-alpha). Conclusions: Despite the positive correlation between probiotics and fecal microbiota/serological markers in pediatric patients with celiac disease, we emphasize the need for future multicentric studies that should include a larger number of patients and a longer follow up period.% |
| first_indexed | 2024-04-12T22:20:34Z |
| format | Article |
| id | doaj.art-4d87539b279f4c898b3edb1ea9729cec |
| institution | Directory Open Access Journal |
| issn | 1984-0462 |
| language | English |
| last_indexed | 2024-04-12T22:20:34Z |
| publisher | Sociedade de Pediatria de São Paulo |
| record_format | Article |
| series | Revista Paulista de Pediatria |
| spelling | doaj.art-4d87539b279f4c898b3edb1ea9729cec2022-12-22T03:14:23ZengSociedade de Pediatria de São PauloRevista Paulista de Pediatria1984-046210.1590/1984-0462/2022/40/2020447The role of probiotics in the immune response and intestinal microbiota of children with celiac disease: a systematic reviewCamila Fernanda JedwabBruna Cardoso de Mattos Boccalini RostonAna Beatriz Ferreira de Souza TogeIsadora Fagundes EcheverriaGuilherme Ojea Gomes TavaresMatheus Alves AlvaresVera Esteves Vagnozzi RulloMarcella Rocha Machado de OliveiraABSTRACT Objective: To evaluate changes in peripheral immunological response (decrease in blood proinflammatory cytokines) and fecal microbiota (especially Bacteroidetes and Firmicutes) after administration of probiotics in children with celiac disease on a gluten-free diet. Data source: The databases MEDLINE, LILACS, Springer and SciELO were used for this review, with the descriptors “celiac disease AND probiotics”. At the end of the search, 168 articles were retrieved, four of which were included in the final qualitative synthesis, having as inclusion criteria randomized clinical trials and pediatric population (1–19 years) and, as exclusion criteria, interventions other than probiotics, studies with patients with other diseases associated with celiac disease, or patients who did not meet the diagnostic criteria. All elected studies were published until September 2020, without language restriction, with patients receiving strains of Bifidobacterium breve or B. longum and on a gluten-free diet. Data synthesis: The studies show that the administration of probiotics along with a gluten-free diet, can approximate the fecal microbiota of celiac patients to typical conditions of healthy individuals, by restoring the abundance of some microbial communities that characterize the typical physiological condition. In addition, the administration of probiotics can reduce serum proinflammatory cytokines (mainly TNF-alpha). Conclusions: Despite the positive correlation between probiotics and fecal microbiota/serological markers in pediatric patients with celiac disease, we emphasize the need for future multicentric studies that should include a larger number of patients and a longer follow up period.%http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822022000100508&tlng=ptCeliac diseaseProbioticsGastrointestinal microbiomeDiet, gluten freeBifidobacterium breveBifidobacterium longum |
| spellingShingle | Camila Fernanda Jedwab Bruna Cardoso de Mattos Boccalini Roston Ana Beatriz Ferreira de Souza Toge Isadora Fagundes Echeverria Guilherme Ojea Gomes Tavares Matheus Alves Alvares Vera Esteves Vagnozzi Rullo Marcella Rocha Machado de Oliveira The role of probiotics in the immune response and intestinal microbiota of children with celiac disease: a systematic review Revista Paulista de Pediatria Celiac disease Probiotics Gastrointestinal microbiome Diet, gluten free Bifidobacterium breve Bifidobacterium longum |
| title | The role of probiotics in the immune response and intestinal microbiota of children with celiac disease: a systematic review |
| title_full | The role of probiotics in the immune response and intestinal microbiota of children with celiac disease: a systematic review |
| title_fullStr | The role of probiotics in the immune response and intestinal microbiota of children with celiac disease: a systematic review |
| title_full_unstemmed | The role of probiotics in the immune response and intestinal microbiota of children with celiac disease: a systematic review |
| title_short | The role of probiotics in the immune response and intestinal microbiota of children with celiac disease: a systematic review |
| title_sort | role of probiotics in the immune response and intestinal microbiota of children with celiac disease a systematic review |
| topic | Celiac disease Probiotics Gastrointestinal microbiome Diet, gluten free Bifidobacterium breve Bifidobacterium longum |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822022000100508&tlng=pt |
| work_keys_str_mv | AT camilafernandajedwab theroleofprobioticsintheimmuneresponseandintestinalmicrobiotaofchildrenwithceliacdiseaseasystematicreview AT brunacardosodemattosboccaliniroston theroleofprobioticsintheimmuneresponseandintestinalmicrobiotaofchildrenwithceliacdiseaseasystematicreview AT anabeatrizferreiradesouzatoge theroleofprobioticsintheimmuneresponseandintestinalmicrobiotaofchildrenwithceliacdiseaseasystematicreview AT isadorafagundesecheverria theroleofprobioticsintheimmuneresponseandintestinalmicrobiotaofchildrenwithceliacdiseaseasystematicreview AT guilhermeojeagomestavares theroleofprobioticsintheimmuneresponseandintestinalmicrobiotaofchildrenwithceliacdiseaseasystematicreview AT matheusalvesalvares theroleofprobioticsintheimmuneresponseandintestinalmicrobiotaofchildrenwithceliacdiseaseasystematicreview AT veraestevesvagnozzirullo theroleofprobioticsintheimmuneresponseandintestinalmicrobiotaofchildrenwithceliacdiseaseasystematicreview AT marcellarochamachadodeoliveira theroleofprobioticsintheimmuneresponseandintestinalmicrobiotaofchildrenwithceliacdiseaseasystematicreview AT camilafernandajedwab roleofprobioticsintheimmuneresponseandintestinalmicrobiotaofchildrenwithceliacdiseaseasystematicreview AT brunacardosodemattosboccaliniroston roleofprobioticsintheimmuneresponseandintestinalmicrobiotaofchildrenwithceliacdiseaseasystematicreview AT anabeatrizferreiradesouzatoge roleofprobioticsintheimmuneresponseandintestinalmicrobiotaofchildrenwithceliacdiseaseasystematicreview AT isadorafagundesecheverria roleofprobioticsintheimmuneresponseandintestinalmicrobiotaofchildrenwithceliacdiseaseasystematicreview AT guilhermeojeagomestavares roleofprobioticsintheimmuneresponseandintestinalmicrobiotaofchildrenwithceliacdiseaseasystematicreview AT matheusalvesalvares roleofprobioticsintheimmuneresponseandintestinalmicrobiotaofchildrenwithceliacdiseaseasystematicreview AT veraestevesvagnozzirullo roleofprobioticsintheimmuneresponseandintestinalmicrobiotaofchildrenwithceliacdiseaseasystematicreview AT marcellarochamachadodeoliveira roleofprobioticsintheimmuneresponseandintestinalmicrobiotaofchildrenwithceliacdiseaseasystematicreview |