Effectiveness of the Use of Three-Dose Intravitreal Ziv-Aflibercept in the Management of Diabetic Macular Edema in a Real-Life Setting
Fernando Munayco-Guillén,1,2 Miguel Angel Vazquez-Membrillo,1,2 Marlon Rafael Garcia-Roa,1,2 Jhony Alberto De La Cruz-Vargas,3 Herney Andrés García-Perdomo,4 Rafael Pichardo-Rodriguez3 1Department of Retina and Vitreous Surgery, Instituto Mexicano de Oftalmología (IMO), Querétaro, México; 2Universid...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-04-01
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| Series: | Clinical Ophthalmology |
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| Online Access: | https://www.dovepress.com/effectiveness-of-the-use-of-three-dose-intravitreal-ziv-aflibercept-in-peer-reviewed-fulltext-article-OPTH |
| _version_ | 1797847423233556480 |
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| author | Munayco-Guillén F Vazquez-Membrillo MA Garcia-Roa MR De La Cruz-Vargas JA García-Perdomo HA Pichardo-Rodriguez R |
| author_facet | Munayco-Guillén F Vazquez-Membrillo MA Garcia-Roa MR De La Cruz-Vargas JA García-Perdomo HA Pichardo-Rodriguez R |
| author_sort | Munayco-Guillén F |
| collection | DOAJ |
| description | Fernando Munayco-Guillén,1,2 Miguel Angel Vazquez-Membrillo,1,2 Marlon Rafael Garcia-Roa,1,2 Jhony Alberto De La Cruz-Vargas,3 Herney Andrés García-Perdomo,4 Rafael Pichardo-Rodriguez3 1Department of Retina and Vitreous Surgery, Instituto Mexicano de Oftalmología (IMO), Querétaro, México; 2Universidad Nacional Autónoma de México (UNAM), México City, México; 3Instituto de Investigaciones en Ciencias Biomédicas (INICIB), Universidad Ricardo Palma, Lima, Perú; 4Division of Urology/Urooncology, Deparment of Surgery, School of Medicine, Universidad del Valle, Cali, ColombiaCorrespondence: Fernando Munayco-Guillén, Fray Servando Teresa de Mier 202, Quintas del Marqués, Querétaro, México, Tel +51 985-558886, Email fernando.munayco.guillen@gmail.comPurpose: It has been reported that intravitreal Ziv-aflibercept is a safe and effective drug for the treatment of diabetes macular edema (DME). The objective of this study was to evaluate in a real-life setting, the efficacy of intravitreal Ziv-aflibercept in the treatment of DME after the administration of three consecutive monthly doses.Methods: A single arm, prospective cohort study. We included patients with DME who received three doses of intravitreal Ziv-aflibercept. Data such as best corrected visual acuity (BCVA) and tomographic biomarkers before treatment and a month after the third dose were collected. DME was staged using the Panozzo classification.Results: Thirty-eight patients participated for a total of 53 eyes. The mean age was 59 ± 8.1 years. We observed significant changes after the third dose in the parameters studied (BCVA in LogMAR pre-treatment (0.6 ± 0.33) and post-treatment (0.4 ± 0.29) [p< 0.001], macular thickness pre-treatment (501 ± 167 μm) and post-treatment (324 ± 114 μm) [p< 0.001], macular volume pre-treatment 10.8 (7.5– 17.8) mm3 and post-treatment 9.3 (0– 13.6) mm3 [p< 0.005]). And 73.6% of the patients presented an advanced severe stage during their pre-treatment evaluation and after post-treatment, 64.2% of the patients no longer presented edema. No systemic or ocular adverse events occurred.Conclusion: The use of three consecutive monthly doses of intravitreal Ziv-aflibercept in a real-life setting is effective and safe in the management of diabetic macular edema.Keywords: antiangiogenic, diabetes mellitus, intravitreal injection, macular edema, optical coherence tomography, Ziv-aflibercept |
| first_indexed | 2024-04-09T18:11:06Z |
| format | Article |
| id | doaj.art-4d89db697b374abfaa7aed3584ffa28b |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-04-09T18:11:06Z |
| publishDate | 2023-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-4d89db697b374abfaa7aed3584ffa28b2023-04-13T19:17:09ZengDove Medical PressClinical Ophthalmology1177-54832023-04-01Volume 171129113582993Effectiveness of the Use of Three-Dose Intravitreal Ziv-Aflibercept in the Management of Diabetic Macular Edema in a Real-Life SettingMunayco-Guillén FVazquez-Membrillo MAGarcia-Roa MRDe La Cruz-Vargas JAGarcía-Perdomo HAPichardo-Rodriguez RFernando Munayco-Guillén,1,2 Miguel Angel Vazquez-Membrillo,1,2 Marlon Rafael Garcia-Roa,1,2 Jhony Alberto De La Cruz-Vargas,3 Herney Andrés García-Perdomo,4 Rafael Pichardo-Rodriguez3 1Department of Retina and Vitreous Surgery, Instituto Mexicano de Oftalmología (IMO), Querétaro, México; 2Universidad Nacional Autónoma de México (UNAM), México City, México; 3Instituto de Investigaciones en Ciencias Biomédicas (INICIB), Universidad Ricardo Palma, Lima, Perú; 4Division of Urology/Urooncology, Deparment of Surgery, School of Medicine, Universidad del Valle, Cali, ColombiaCorrespondence: Fernando Munayco-Guillén, Fray Servando Teresa de Mier 202, Quintas del Marqués, Querétaro, México, Tel +51 985-558886, Email fernando.munayco.guillen@gmail.comPurpose: It has been reported that intravitreal Ziv-aflibercept is a safe and effective drug for the treatment of diabetes macular edema (DME). The objective of this study was to evaluate in a real-life setting, the efficacy of intravitreal Ziv-aflibercept in the treatment of DME after the administration of three consecutive monthly doses.Methods: A single arm, prospective cohort study. We included patients with DME who received three doses of intravitreal Ziv-aflibercept. Data such as best corrected visual acuity (BCVA) and tomographic biomarkers before treatment and a month after the third dose were collected. DME was staged using the Panozzo classification.Results: Thirty-eight patients participated for a total of 53 eyes. The mean age was 59 ± 8.1 years. We observed significant changes after the third dose in the parameters studied (BCVA in LogMAR pre-treatment (0.6 ± 0.33) and post-treatment (0.4 ± 0.29) [p< 0.001], macular thickness pre-treatment (501 ± 167 μm) and post-treatment (324 ± 114 μm) [p< 0.001], macular volume pre-treatment 10.8 (7.5– 17.8) mm3 and post-treatment 9.3 (0– 13.6) mm3 [p< 0.005]). And 73.6% of the patients presented an advanced severe stage during their pre-treatment evaluation and after post-treatment, 64.2% of the patients no longer presented edema. No systemic or ocular adverse events occurred.Conclusion: The use of three consecutive monthly doses of intravitreal Ziv-aflibercept in a real-life setting is effective and safe in the management of diabetic macular edema.Keywords: antiangiogenic, diabetes mellitus, intravitreal injection, macular edema, optical coherence tomography, Ziv-aflibercepthttps://www.dovepress.com/effectiveness-of-the-use-of-three-dose-intravitreal-ziv-aflibercept-in-peer-reviewed-fulltext-article-OPTHantiangiogenic diabetes mellitus intravitreal injection macular edema optical coherence tomography ziv-aflibercept |
| spellingShingle | Munayco-Guillén F Vazquez-Membrillo MA Garcia-Roa MR De La Cruz-Vargas JA García-Perdomo HA Pichardo-Rodriguez R Effectiveness of the Use of Three-Dose Intravitreal Ziv-Aflibercept in the Management of Diabetic Macular Edema in a Real-Life Setting Clinical Ophthalmology antiangiogenic diabetes mellitus intravitreal injection macular edema optical coherence tomography ziv-aflibercept |
| title | Effectiveness of the Use of Three-Dose Intravitreal Ziv-Aflibercept in the Management of Diabetic Macular Edema in a Real-Life Setting |
| title_full | Effectiveness of the Use of Three-Dose Intravitreal Ziv-Aflibercept in the Management of Diabetic Macular Edema in a Real-Life Setting |
| title_fullStr | Effectiveness of the Use of Three-Dose Intravitreal Ziv-Aflibercept in the Management of Diabetic Macular Edema in a Real-Life Setting |
| title_full_unstemmed | Effectiveness of the Use of Three-Dose Intravitreal Ziv-Aflibercept in the Management of Diabetic Macular Edema in a Real-Life Setting |
| title_short | Effectiveness of the Use of Three-Dose Intravitreal Ziv-Aflibercept in the Management of Diabetic Macular Edema in a Real-Life Setting |
| title_sort | effectiveness of the use of three dose intravitreal ziv aflibercept in the management of diabetic macular edema in a real life setting |
| topic | antiangiogenic diabetes mellitus intravitreal injection macular edema optical coherence tomography ziv-aflibercept |
| url | https://www.dovepress.com/effectiveness-of-the-use-of-three-dose-intravitreal-ziv-aflibercept-in-peer-reviewed-fulltext-article-OPTH |
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