Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system

Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system

IntroductionProgranulin (PGRN) is a secreted glycoprotein, the expression of which is linked to several neurodegenerative diseases. Although its specific function is still unclear, several studies have linked it with lysosomal functions and immune system regulation. Here, we have explored the role o...

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Bibliographic Details
Main Authors: Madelyn C. Houser, Oihane Uriarte Huarte, Rebecca L. Wallings, Cody E. Keating, Kathryn P. MacPherson, Mary K. Herrick, George T. Kannarkat, Sean D. Kelly, Jianjun Chang, Nicholas H. Varvel, Jessica E. Rexach, Malú Gámez Tansey
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
progranulin
peripheral-brain crosstalk
microglia
monocytes
T cells
GPNMB
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1056417/full

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