Recognize and Treatment of Digitalis Intoxication
Background: Digitalis is the oldest compound in cardiovascular medicine that continues to be used in contemporary clinical practice. It is one of the most frequently prescribed medications and has historically been implicated as one of the most common causes of adverse drug reactions. Despite the fa...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Indonesian Heart Association
2013-06-01
|
| Series: | Majalah Kardiologi Indonesia |
| Subjects: | |
| Online Access: | http://ijconline.id/index.php/ijc/article/view/120 |
| _version_ | 1819014188258820096 |
|---|---|
| author | Dewi H Suprobo Bambang B Siswanto Yoga Yuniadi Ganesja M Harimurti |
| author_facet | Dewi H Suprobo Bambang B Siswanto Yoga Yuniadi Ganesja M Harimurti |
| author_sort | Dewi H Suprobo |
| collection | DOAJ |
| description | Background: Digitalis is the oldest compound in cardiovascular medicine that continues to be used in contemporary clinical practice. It is one of the most frequently prescribed medications and has historically been implicated as one of the most common causes of adverse drug reactions. Despite the fact that digitalis preparations have been used therapeutically for more than 200 years, diagnosis of digoxin toxicity remains difficult. Signs and symptoms associated with toxicity are nonspecific, as are electrocardiographic changes, and the therapeutic and toxic concentrations overlap.
Objective: to present a case report of digoxin intoxication and to review the diagnosis and management of the disease.
Summary: We have reported a case related to intoxication of a drug that is one of the most frequently prescribed medications and has historically been implicated as one of the most common causes of adverse drug reactions. This fact is reasonable since digoxin has a narrow margin of safety, where at the therapeutic dosage digoxin could induce intoxication. Moreover the response to this drug is influenced by many factors. Although the general manifestation of digoxin intoxication is not specified, but in patient who are in digoxin therapy with clinical manifestation of digoxin intoxication, we have to put digoxin intoxication as one of our differential diagnosis. The diagnosis is supported by the ECG manifestation and confirmed by the examination of serum digoxin level. Eventhough, normal digoxin level could also induce intoxication. The initial management of digoxin intoxication is early recog -nition that a dysrhythmia and/or noncardiac manifestation may be related to digitalis intoxication and stop the digoxin therapy. Immunotherapy, in hemodynamically stable or unstable patients, is a first-line therapy. |
| first_indexed | 2024-12-21T02:11:52Z |
| format | Article |
| id | doaj.art-4d8bbfe9fe964293af021cee57dfa4a0 |
| institution | Directory Open Access Journal |
| issn | 0126-3773 2620-4762 |
| language | English |
| last_indexed | 2024-12-21T02:11:52Z |
| publishDate | 2013-06-01 |
| publisher | Indonesian Heart Association |
| record_format | Article |
| series | Majalah Kardiologi Indonesia |
| spelling | doaj.art-4d8bbfe9fe964293af021cee57dfa4a02022-12-21T19:19:21ZengIndonesian Heart AssociationMajalah Kardiologi Indonesia0126-37732620-47622013-06-0132110.30701/ijc.v32i1.120Recognize and Treatment of Digitalis IntoxicationDewi H Suprobo0Bambang B Siswanto1Yoga Yuniadi2Ganesja M Harimurti3Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia National Cardiovascular Center Harapan Kita, JakartaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia National Cardiovascular Center Harapan Kita, JakartaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia National Cardiovascular Center Harapan Kita, JakartaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia National Cardiovascular Center Harapan Kita, JakartaBackground: Digitalis is the oldest compound in cardiovascular medicine that continues to be used in contemporary clinical practice. It is one of the most frequently prescribed medications and has historically been implicated as one of the most common causes of adverse drug reactions. Despite the fact that digitalis preparations have been used therapeutically for more than 200 years, diagnosis of digoxin toxicity remains difficult. Signs and symptoms associated with toxicity are nonspecific, as are electrocardiographic changes, and the therapeutic and toxic concentrations overlap. Objective: to present a case report of digoxin intoxication and to review the diagnosis and management of the disease. Summary: We have reported a case related to intoxication of a drug that is one of the most frequently prescribed medications and has historically been implicated as one of the most common causes of adverse drug reactions. This fact is reasonable since digoxin has a narrow margin of safety, where at the therapeutic dosage digoxin could induce intoxication. Moreover the response to this drug is influenced by many factors. Although the general manifestation of digoxin intoxication is not specified, but in patient who are in digoxin therapy with clinical manifestation of digoxin intoxication, we have to put digoxin intoxication as one of our differential diagnosis. The diagnosis is supported by the ECG manifestation and confirmed by the examination of serum digoxin level. Eventhough, normal digoxin level could also induce intoxication. The initial management of digoxin intoxication is early recog -nition that a dysrhythmia and/or noncardiac manifestation may be related to digitalis intoxication and stop the digoxin therapy. Immunotherapy, in hemodynamically stable or unstable patients, is a first-line therapy.http://ijconline.id/index.php/ijc/article/view/120digoxin intoxicationarrhythmiadigoxin level |
| spellingShingle | Dewi H Suprobo Bambang B Siswanto Yoga Yuniadi Ganesja M Harimurti Recognize and Treatment of Digitalis Intoxication Majalah Kardiologi Indonesia digoxin intoxication arrhythmia digoxin level |
| title | Recognize and Treatment of Digitalis Intoxication |
| title_full | Recognize and Treatment of Digitalis Intoxication |
| title_fullStr | Recognize and Treatment of Digitalis Intoxication |
| title_full_unstemmed | Recognize and Treatment of Digitalis Intoxication |
| title_short | Recognize and Treatment of Digitalis Intoxication |
| title_sort | recognize and treatment of digitalis intoxication |
| topic | digoxin intoxication arrhythmia digoxin level |
| url | http://ijconline.id/index.php/ijc/article/view/120 |
| work_keys_str_mv | AT dewihsuprobo recognizeandtreatmentofdigitalisintoxication AT bambangbsiswanto recognizeandtreatmentofdigitalisintoxication AT yogayuniadi recognizeandtreatmentofdigitalisintoxication AT ganesjamharimurti recognizeandtreatmentofdigitalisintoxication |