Reduction of Sphingosine Kinase 1 Phosphorylation and Activity in Plasmodium-Infected Erythrocytes

Reduction of Sphingosine Kinase 1 Phosphorylation and Activity in Plasmodium-Infected Erythrocytes

Sphingosine-1-phosphate (S1P), a bioactive lipid mediator is involved in an array of biological processes and linked to pathological manifestations. Erythrocyte is known as the major reservoir for S1P as they lack S1P-degrading enzymes (S1P lyase and S1P phosphohydrolase) and harbor sphingosine kina...

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Bibliographic Details
Main Authors: Raj Kumar Sah, Soumya Pati, Monika Saini, Pon Arunachalam Boopathi, Sanjay Kumar Kochar, Dhanpat Kumar Kochar, Ashis Das, Shailja Singh
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
erythrocytes
Plasmodium falciparum
Plasmodium vivax
sphingosine kinase-1
sphingosine-1-phosphate
complicated malaria
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00080/full

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