Can inhaled cannabis users accurately evaluate impaired driving ability? A randomized controlled trial
AimsTo study the effect of inhaled cannabis on self-assessed predicted driving ability and its relation to reaction times and driving ability on a driving simulator.Participants and methods30 healthy male volunteers aged 18–34: 15 chronic (1–2 joints /day) and 15 occasional (1–2 joints/week) consume...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1234765/full |
| _version_ | 1797489723861630976 |
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| author | Sarah Hartley Nicolas Simon Bibiana Cardozo Islam Amine Larabi Jean Claude Alvarez |
| author_facet | Sarah Hartley Nicolas Simon Bibiana Cardozo Islam Amine Larabi Jean Claude Alvarez |
| author_sort | Sarah Hartley |
| collection | DOAJ |
| description | AimsTo study the effect of inhaled cannabis on self-assessed predicted driving ability and its relation to reaction times and driving ability on a driving simulator.Participants and methods30 healthy male volunteers aged 18–34: 15 chronic (1–2 joints /day) and 15 occasional (1–2 joints/week) consumers. Self-assessed driving confidence (visual analog scale), vigilance (Karolinska), reaction time (mean reciprocal reaction time mRRT, psychomotor vigilance test), driving ability (standard deviation of lane position SDLP on a York driving simulator) and blood concentrations of delta-9-tétrahydrocannabinol (THC) were measured before and repeatedly after controlled inhalation of placebo, 10 mg or 30 mg of THC mixed with tobacco in a cigarette.ResultsCannabis consumption (at 10 and 30 mg) led to a marked decrease in driving confidence over the first 2 h which remained below baseline at 8 h. Driving confidence was related to THC dose and to THC concentrations in the effective compartment with a low concentration of 0.11 ng/ml for the EC50 and a rapid onset of action (T1/2 37 min). Driving ability and reaction times were reduced by cannabis consumption. Driving confidence was shown to be related to driving ability and reaction times in both chronic and occasional consumers.ConclusionsCannabis consumption leads to a rapid reduction in driving confidence which is related to reduced ability on a driving simulator.Clinical trial registrationClinicalTrials.gov, identifier: NCT02061020. |
| first_indexed | 2024-03-10T00:20:44Z |
| format | Article |
| id | doaj.art-4d8d4e647fbf4182938d3a44dcb76f88 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-10T00:20:44Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-4d8d4e647fbf4182938d3a44dcb76f882023-11-23T15:42:33ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-11-011110.3389/fpubh.2023.12347651234765Can inhaled cannabis users accurately evaluate impaired driving ability? A randomized controlled trialSarah Hartley0Nicolas Simon1Bibiana Cardozo2Islam Amine Larabi3Jean Claude Alvarez4Sleep Unit, Physiology Department, AP-HP GHU Paris-Saclay, Raymond Poincaré Hospital, Garches, FranceDepartment of Clinical Pharmacology, Aix Marseille Univ, APHM, INSERM, IRD, SESSTIM, Hop Sainte Marguerite, CAP-TV, Marseille, FranceDepartment of Clinical Pharmacology, Aix Marseille Univ, APHM, INSERM, IRD, SESSTIM, Hop Sainte Marguerite, CAP-TV, Marseille, FrancePlateform MasSpecLab, Department of Pharmacology and Toxicology, Raymond Poincaré Hospital, GHU AP-HP.Paris-Saclay, Paris-Saclay University, UVSQ, Inserm U-1018, CESP, Team MOODS, Garches, FrancePlateform MasSpecLab, Department of Pharmacology and Toxicology, Raymond Poincaré Hospital, GHU AP-HP.Paris-Saclay, Paris-Saclay University, UVSQ, Inserm U-1018, CESP, Team MOODS, Garches, FranceAimsTo study the effect of inhaled cannabis on self-assessed predicted driving ability and its relation to reaction times and driving ability on a driving simulator.Participants and methods30 healthy male volunteers aged 18–34: 15 chronic (1–2 joints /day) and 15 occasional (1–2 joints/week) consumers. Self-assessed driving confidence (visual analog scale), vigilance (Karolinska), reaction time (mean reciprocal reaction time mRRT, psychomotor vigilance test), driving ability (standard deviation of lane position SDLP on a York driving simulator) and blood concentrations of delta-9-tétrahydrocannabinol (THC) were measured before and repeatedly after controlled inhalation of placebo, 10 mg or 30 mg of THC mixed with tobacco in a cigarette.ResultsCannabis consumption (at 10 and 30 mg) led to a marked decrease in driving confidence over the first 2 h which remained below baseline at 8 h. Driving confidence was related to THC dose and to THC concentrations in the effective compartment with a low concentration of 0.11 ng/ml for the EC50 and a rapid onset of action (T1/2 37 min). Driving ability and reaction times were reduced by cannabis consumption. Driving confidence was shown to be related to driving ability and reaction times in both chronic and occasional consumers.ConclusionsCannabis consumption leads to a rapid reduction in driving confidence which is related to reduced ability on a driving simulator.Clinical trial registrationClinicalTrials.gov, identifier: NCT02061020.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1234765/fullcannabisdrivingdriving simulatorreaction timeaccident |
| spellingShingle | Sarah Hartley Nicolas Simon Bibiana Cardozo Islam Amine Larabi Jean Claude Alvarez Can inhaled cannabis users accurately evaluate impaired driving ability? A randomized controlled trial Frontiers in Public Health cannabis driving driving simulator reaction time accident |
| title | Can inhaled cannabis users accurately evaluate impaired driving ability? A randomized controlled trial |
| title_full | Can inhaled cannabis users accurately evaluate impaired driving ability? A randomized controlled trial |
| title_fullStr | Can inhaled cannabis users accurately evaluate impaired driving ability? A randomized controlled trial |
| title_full_unstemmed | Can inhaled cannabis users accurately evaluate impaired driving ability? A randomized controlled trial |
| title_short | Can inhaled cannabis users accurately evaluate impaired driving ability? A randomized controlled trial |
| title_sort | can inhaled cannabis users accurately evaluate impaired driving ability a randomized controlled trial |
| topic | cannabis driving driving simulator reaction time accident |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1234765/full |
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