The Clinical Utility of Systemic Immune-Inflammation Index Supporting Charlson Comorbidity Index and CAPRA-S Score in Determining Survival after Radical Prostatectomy—A Single Centre Study
The selection of candidates for the curative treatment of PCa requires a careful assessment of life expectancy. Recently, blood-count inflammatory markers have been introduced as prognosticators of oncological and non-oncological outcomes in different settings. This retrospective, monocentric study...
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MDPI AG
2022-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/17/4135 |
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| author | Piotr Zapała Karolina Garbas Zbigniew Lewandowski Łukasz Zapała Aleksander Ślusarczyk Cezary Ślusarczyk Łukasz Mielczarek Piotr Radziszewski |
| author_facet | Piotr Zapała Karolina Garbas Zbigniew Lewandowski Łukasz Zapała Aleksander Ślusarczyk Cezary Ślusarczyk Łukasz Mielczarek Piotr Radziszewski |
| author_sort | Piotr Zapała |
| collection | DOAJ |
| description | The selection of candidates for the curative treatment of PCa requires a careful assessment of life expectancy. Recently, blood-count inflammatory markers have been introduced as prognosticators of oncological and non-oncological outcomes in different settings. This retrospective, monocentric study included 421 patients treated with radical prostatectomy (RP) for nonmetastatic PCa and aimed at determining the utility of a preoperative SII (neutrophil count × platelet count/lymphocyte count) in predicting survival after RP. Patients with high SIIs (≥900) presented significantly shorter survival (<i>p</i> = 0.02) and high SIIs constituted an independent predictor of overall survival [HR 2.54 (95%CI 1.24–5.21); <i>p</i> = 0.01] when adjusted for high (≥6) age-adjusted CCI (ACCI) [HR 2.75 (95%CI 1.27–5.95); <i>p</i> = 0.01] and high (≥6) CAPRA-S [HR 2.65 (95%CI 1.32–5.31); <i>p</i> = 0.006]. Patients with high scores (ACCI and/or CAPRA-S) and high SIIs were at the highest risk of death (<i>p</i> < 0.0001) with approximately a one-year survival loss during the first seven years after surgery. In subgroup of high CAPRA-S (≥6), patients with high ACCIs and high SIIs were at the highest risk of death (<i>p</i> <0.0001). Our study introduces the SII as a straightforward marker of mortality after RP that can be helpful in pre- and postoperative decision-making. |
| first_indexed | 2024-03-10T01:58:45Z |
| format | Article |
| id | doaj.art-4d8d532f1edf4d1a92b952ce5f344b98 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T01:58:45Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4d8d532f1edf4d1a92b952ce5f344b982023-11-23T12:50:27ZengMDPI AGCancers2072-66942022-08-011417413510.3390/cancers14174135The Clinical Utility of Systemic Immune-Inflammation Index Supporting Charlson Comorbidity Index and CAPRA-S Score in Determining Survival after Radical Prostatectomy—A Single Centre StudyPiotr Zapała0Karolina Garbas1Zbigniew Lewandowski2Łukasz Zapała3Aleksander Ślusarczyk4Cezary Ślusarczyk5Łukasz Mielczarek6Piotr Radziszewski7Clinic of General, Oncological and Functional Urology, Medical University of Warsaw, Lindleya 4, 02-005 Warsaw, PolandClinic of General, Oncological and Functional Urology, Medical University of Warsaw, Lindleya 4, 02-005 Warsaw, PolandDepartment of Epidemiology, Medical University of Warsaw, Oczki 3, 02-007 Warsaw, PolandClinic of General, Oncological and Functional Urology, Medical University of Warsaw, Lindleya 4, 02-005 Warsaw, PolandClinic of General, Oncological and Functional Urology, Medical University of Warsaw, Lindleya 4, 02-005 Warsaw, PolandClinic of General, Oncological and Functional Urology, Medical University of Warsaw, Lindleya 4, 02-005 Warsaw, PolandSecond Department of Urology, Centre of Postgraduate Medical Education, Cegłowska 80, 01-809 Warsaw, PolandClinic of General, Oncological and Functional Urology, Medical University of Warsaw, Lindleya 4, 02-005 Warsaw, PolandThe selection of candidates for the curative treatment of PCa requires a careful assessment of life expectancy. Recently, blood-count inflammatory markers have been introduced as prognosticators of oncological and non-oncological outcomes in different settings. This retrospective, monocentric study included 421 patients treated with radical prostatectomy (RP) for nonmetastatic PCa and aimed at determining the utility of a preoperative SII (neutrophil count × platelet count/lymphocyte count) in predicting survival after RP. Patients with high SIIs (≥900) presented significantly shorter survival (<i>p</i> = 0.02) and high SIIs constituted an independent predictor of overall survival [HR 2.54 (95%CI 1.24–5.21); <i>p</i> = 0.01] when adjusted for high (≥6) age-adjusted CCI (ACCI) [HR 2.75 (95%CI 1.27–5.95); <i>p</i> = 0.01] and high (≥6) CAPRA-S [HR 2.65 (95%CI 1.32–5.31); <i>p</i> = 0.006]. Patients with high scores (ACCI and/or CAPRA-S) and high SIIs were at the highest risk of death (<i>p</i> < 0.0001) with approximately a one-year survival loss during the first seven years after surgery. In subgroup of high CAPRA-S (≥6), patients with high ACCIs and high SIIs were at the highest risk of death (<i>p</i> <0.0001). Our study introduces the SII as a straightforward marker of mortality after RP that can be helpful in pre- and postoperative decision-making.https://www.mdpi.com/2072-6694/14/17/4135prostate cancerlife expectancysystemic immune-inflammation indexCharlson comorbidity indexCAPRA-Searly survival |
| spellingShingle | Piotr Zapała Karolina Garbas Zbigniew Lewandowski Łukasz Zapała Aleksander Ślusarczyk Cezary Ślusarczyk Łukasz Mielczarek Piotr Radziszewski The Clinical Utility of Systemic Immune-Inflammation Index Supporting Charlson Comorbidity Index and CAPRA-S Score in Determining Survival after Radical Prostatectomy—A Single Centre Study Cancers prostate cancer life expectancy systemic immune-inflammation index Charlson comorbidity index CAPRA-S early survival |
| title | The Clinical Utility of Systemic Immune-Inflammation Index Supporting Charlson Comorbidity Index and CAPRA-S Score in Determining Survival after Radical Prostatectomy—A Single Centre Study |
| title_full | The Clinical Utility of Systemic Immune-Inflammation Index Supporting Charlson Comorbidity Index and CAPRA-S Score in Determining Survival after Radical Prostatectomy—A Single Centre Study |
| title_fullStr | The Clinical Utility of Systemic Immune-Inflammation Index Supporting Charlson Comorbidity Index and CAPRA-S Score in Determining Survival after Radical Prostatectomy—A Single Centre Study |
| title_full_unstemmed | The Clinical Utility of Systemic Immune-Inflammation Index Supporting Charlson Comorbidity Index and CAPRA-S Score in Determining Survival after Radical Prostatectomy—A Single Centre Study |
| title_short | The Clinical Utility of Systemic Immune-Inflammation Index Supporting Charlson Comorbidity Index and CAPRA-S Score in Determining Survival after Radical Prostatectomy—A Single Centre Study |
| title_sort | clinical utility of systemic immune inflammation index supporting charlson comorbidity index and capra s score in determining survival after radical prostatectomy a single centre study |
| topic | prostate cancer life expectancy systemic immune-inflammation index Charlson comorbidity index CAPRA-S early survival |
| url | https://www.mdpi.com/2072-6694/14/17/4135 |
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