In Vivo siRNA Delivery to Immunosuppressive Liver Macrophages by α-Mannosyl-Functionalized Cationic Nanohydrogel Particles

In Vivo siRNA Delivery to Immunosuppressive Liver Macrophages by α-Mannosyl-Functionalized Cationic Nanohydrogel Particles

Macrophages are the front soldiers of the innate immune system and are vital for immune defense, tumor surveillance, and tissue homeostasis. In chronic diseases, including cancer and liver fibrosis, macrophages can be forced into an immunosuppressive and profibrotic M2 phenotype. M2-type macrophages...

Full description

Bibliographic Details
Main Authors: Leonard Kaps, Nadine Leber, Adrian Klefenz, Niklas Choteschovsky, Rudolf Zentel, Lutz Nuhn, Detlef Schuppan
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
nanohydrogels
mannose targeting
M2 macrophages
gene knock-down
siRNA delivery
fibrosis
Online Access:https://www.mdpi.com/2073-4409/9/8/1905

Similar Items

Similar Items