Psychosocial Pre-Transplant Screening With the Transplant Evaluation Rating Scale Contributes to Prediction of Survival After Hematopoietic Stem Cell Transplantation
There is no standard in hematopoietic stem cell transplantations (HSCT) for pre-transplant screening of psychosocial risk factors, e.g., regarding immunosuppressant non-adherence. The aim of this prospective study is to explore the predictive value of the pretransplant psychosocial screening instrum...
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.741438/full |
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| author | Simon Scherer Simon Scherer Christoph Scheid Michael von Bergwelt Martin Hellmich Christian Albus Frank Vitinius |
| author_facet | Simon Scherer Simon Scherer Christoph Scheid Michael von Bergwelt Martin Hellmich Christian Albus Frank Vitinius |
| author_sort | Simon Scherer |
| collection | DOAJ |
| description | There is no standard in hematopoietic stem cell transplantations (HSCT) for pre-transplant screening of psychosocial risk factors, e.g., regarding immunosuppressant non-adherence. The aim of this prospective study is to explore the predictive value of the pretransplant psychosocial screening instrument Transplant Evaluation Rating Scale (TERS) for mortality in a 3-year follow-up. Between 2012 and 2017 61 patients were included and classified as low (TERS = 26.5–29) and increased-risk group (TERS = 29.5–79.5). Both groups were compared regarding mortality until 36 months after transplantation and secondary outcomes [Medication Experience Scale for Immunosuppressants (MESI); incidence/grade of GvHD]. The increased-risk group (n = 28) showed significantly worse cumulative survival in the outpatient setting (from 3 months to 3 years after HSCT) [Log Rank (Mantel Cox) P = 0.029] compared to low-risk group (n = 29) but there was no significant result for the interval immediately after HSCT until 3 years afterwards. Pre-transplant screening with TERS contributes to prediction of survival after HSCT. The reason remains unclear, since TERS did not correlate with GvHD or MESI. The negative result regarding the interval immediately after HSCT until 3 years could be caused by the intensive in-patient setting with mortality which is explained rather by biological reasons than by non-adherence. |
| first_indexed | 2024-12-13T20:20:06Z |
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| id | doaj.art-4d8fb33d496f45faae19e947334efa14 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-13T20:20:06Z |
| publishDate | 2021-10-01 |
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| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-4d8fb33d496f45faae19e947334efa142022-12-21T23:32:42ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-10-011210.3389/fpsyt.2021.741438741438Psychosocial Pre-Transplant Screening With the Transplant Evaluation Rating Scale Contributes to Prediction of Survival After Hematopoietic Stem Cell TransplantationSimon Scherer0Simon Scherer1Christoph Scheid2Michael von Bergwelt3Martin Hellmich4Christian Albus5Frank Vitinius6Department of Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, GermanyDepartment of Pediatric Surgery and Pediatric Urology, University Children's Hospital, University Hospital Tuebingen, Tuebingen, GermanyDepartment I of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, GermanyDepartment III of Internal Medicine, Ludwig Maximilian University of Munich, Munich, GermanyFaculty of Medicine and University Hospital Cologne, Institute of Medical Statistics and Computational Biology, University of Cologne, Cologne, GermanyDepartment of Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, GermanyDepartment of Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, GermanyThere is no standard in hematopoietic stem cell transplantations (HSCT) for pre-transplant screening of psychosocial risk factors, e.g., regarding immunosuppressant non-adherence. The aim of this prospective study is to explore the predictive value of the pretransplant psychosocial screening instrument Transplant Evaluation Rating Scale (TERS) for mortality in a 3-year follow-up. Between 2012 and 2017 61 patients were included and classified as low (TERS = 26.5–29) and increased-risk group (TERS = 29.5–79.5). Both groups were compared regarding mortality until 36 months after transplantation and secondary outcomes [Medication Experience Scale for Immunosuppressants (MESI); incidence/grade of GvHD]. The increased-risk group (n = 28) showed significantly worse cumulative survival in the outpatient setting (from 3 months to 3 years after HSCT) [Log Rank (Mantel Cox) P = 0.029] compared to low-risk group (n = 29) but there was no significant result for the interval immediately after HSCT until 3 years afterwards. Pre-transplant screening with TERS contributes to prediction of survival after HSCT. The reason remains unclear, since TERS did not correlate with GvHD or MESI. The negative result regarding the interval immediately after HSCT until 3 years could be caused by the intensive in-patient setting with mortality which is explained rather by biological reasons than by non-adherence.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.741438/fullpre-transplant evaluationtransplant evaluation rating scaleadherencepatient survivalgraft-vs.-host diseasemedication experience scale for immunosuppressants |
| spellingShingle | Simon Scherer Simon Scherer Christoph Scheid Michael von Bergwelt Martin Hellmich Christian Albus Frank Vitinius Psychosocial Pre-Transplant Screening With the Transplant Evaluation Rating Scale Contributes to Prediction of Survival After Hematopoietic Stem Cell Transplantation Frontiers in Psychiatry pre-transplant evaluation transplant evaluation rating scale adherence patient survival graft-vs.-host disease medication experience scale for immunosuppressants |
| title | Psychosocial Pre-Transplant Screening With the Transplant Evaluation Rating Scale Contributes to Prediction of Survival After Hematopoietic Stem Cell Transplantation |
| title_full | Psychosocial Pre-Transplant Screening With the Transplant Evaluation Rating Scale Contributes to Prediction of Survival After Hematopoietic Stem Cell Transplantation |
| title_fullStr | Psychosocial Pre-Transplant Screening With the Transplant Evaluation Rating Scale Contributes to Prediction of Survival After Hematopoietic Stem Cell Transplantation |
| title_full_unstemmed | Psychosocial Pre-Transplant Screening With the Transplant Evaluation Rating Scale Contributes to Prediction of Survival After Hematopoietic Stem Cell Transplantation |
| title_short | Psychosocial Pre-Transplant Screening With the Transplant Evaluation Rating Scale Contributes to Prediction of Survival After Hematopoietic Stem Cell Transplantation |
| title_sort | psychosocial pre transplant screening with the transplant evaluation rating scale contributes to prediction of survival after hematopoietic stem cell transplantation |
| topic | pre-transplant evaluation transplant evaluation rating scale adherence patient survival graft-vs.-host disease medication experience scale for immunosuppressants |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.741438/full |
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