The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss
Aging is associated with impairment of sensorial functions and with the onset of neurodegenerative diseases. As pari passu circulating insulin-like growth factor 1 (IGF-1) bioavailability progressively decreases, we see a direct correlation with sensory impairment and cognitive performance in older...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-12-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fnagi.2017.00411/full |
| _version_ | 1818607037040295936 |
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| author | Lourdes Rodríguez-de la Rosa Lourdes Rodríguez-de la Rosa Lourdes Rodríguez-de la Rosa Luis Lassaletta Luis Lassaletta Luis Lassaletta Luis Lassaletta Miryam Calvino Miryam Calvino Silvia Murillo-Cuesta Silvia Murillo-Cuesta Silvia Murillo-Cuesta Isabel Varela-Nieto Isabel Varela-Nieto Isabel Varela-Nieto |
| author_facet | Lourdes Rodríguez-de la Rosa Lourdes Rodríguez-de la Rosa Lourdes Rodríguez-de la Rosa Luis Lassaletta Luis Lassaletta Luis Lassaletta Luis Lassaletta Miryam Calvino Miryam Calvino Silvia Murillo-Cuesta Silvia Murillo-Cuesta Silvia Murillo-Cuesta Isabel Varela-Nieto Isabel Varela-Nieto Isabel Varela-Nieto |
| author_sort | Lourdes Rodríguez-de la Rosa |
| collection | DOAJ |
| description | Aging is associated with impairment of sensorial functions and with the onset of neurodegenerative diseases. As pari passu circulating insulin-like growth factor 1 (IGF-1) bioavailability progressively decreases, we see a direct correlation with sensory impairment and cognitive performance in older humans. Age-related sensory loss is typically caused by the irreversible death of highly differentiated neurons and sensory receptor cells. Among sensory deficits, age-related hearing loss (ARHL), also named presbycusis, affects one third of the population over 65 years of age and is a major factor in the progression of cognitive problems in the elderly. The genetic and molecular bases of ARHL are largely unknown and only a few genes related to susceptibility to oxidative stress, excitotoxicity, and cell death have been identified. IGF-1 is known to be a neuroprotective agent that maintains cellular metabolism, activates growth, proliferation and differentiation, and limits cell death. Inborn IGF-1 deficiency leads to profound sensorineural hearing loss both in humans and mice. IGF-1 haploinsufficiency has also been shown to correlate with ARHL. There is not much information available on the effect of IGF-1 deficiency on other human sensory systems, but experimental models show a long-term impact on the retina. A secondary action of IGF-1 is the control of oxidative stress and inflammation, thus helping to resolve damage situations, acute or made chronic by aging. Here we will review the primary actions of IGF-1 in the auditory system and the underlying molecular mechanisms. |
| first_indexed | 2024-12-16T14:20:22Z |
| format | Article |
| id | doaj.art-4d9009d1454e4f67958290d34a2fbac8 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-16T14:20:22Z |
| publishDate | 2017-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-4d9009d1454e4f67958290d34a2fbac82022-12-21T22:28:31ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652017-12-01910.3389/fnagi.2017.00411320001The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing LossLourdes Rodríguez-de la Rosa0Lourdes Rodríguez-de la Rosa1Lourdes Rodríguez-de la Rosa2Luis Lassaletta3Luis Lassaletta4Luis Lassaletta5Luis Lassaletta6Miryam Calvino7Miryam Calvino8Silvia Murillo-Cuesta9Silvia Murillo-Cuesta10Silvia Murillo-Cuesta11Isabel Varela-Nieto12Isabel Varela-Nieto13Isabel Varela-Nieto14“Alberto Sols” Biomedical Research Institute CSIC-UAM, Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, SpainHospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain“Alberto Sols” Biomedical Research Institute CSIC-UAM, Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, SpainHospital La Paz Institute for Health Research (IdiPAZ), Madrid, SpainOtorhinolaryngology Department, Hospital La Paz, Madrid, SpainHospital La Paz Institute for Health Research (IdiPAZ), Madrid, SpainOtorhinolaryngology Department, Hospital La Paz, Madrid, Spain“Alberto Sols” Biomedical Research Institute CSIC-UAM, Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, SpainHospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain“Alberto Sols” Biomedical Research Institute CSIC-UAM, Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, SpainHospital La Paz Institute for Health Research (IdiPAZ), Madrid, SpainAging is associated with impairment of sensorial functions and with the onset of neurodegenerative diseases. As pari passu circulating insulin-like growth factor 1 (IGF-1) bioavailability progressively decreases, we see a direct correlation with sensory impairment and cognitive performance in older humans. Age-related sensory loss is typically caused by the irreversible death of highly differentiated neurons and sensory receptor cells. Among sensory deficits, age-related hearing loss (ARHL), also named presbycusis, affects one third of the population over 65 years of age and is a major factor in the progression of cognitive problems in the elderly. The genetic and molecular bases of ARHL are largely unknown and only a few genes related to susceptibility to oxidative stress, excitotoxicity, and cell death have been identified. IGF-1 is known to be a neuroprotective agent that maintains cellular metabolism, activates growth, proliferation and differentiation, and limits cell death. Inborn IGF-1 deficiency leads to profound sensorineural hearing loss both in humans and mice. IGF-1 haploinsufficiency has also been shown to correlate with ARHL. There is not much information available on the effect of IGF-1 deficiency on other human sensory systems, but experimental models show a long-term impact on the retina. A secondary action of IGF-1 is the control of oxidative stress and inflammation, thus helping to resolve damage situations, acute or made chronic by aging. Here we will review the primary actions of IGF-1 in the auditory system and the underlying molecular mechanisms.http://journal.frontiersin.org/article/10.3389/fnagi.2017.00411/fullARHLGHIGF systempresbycusisrare diseases |
| spellingShingle | Lourdes Rodríguez-de la Rosa Lourdes Rodríguez-de la Rosa Lourdes Rodríguez-de la Rosa Luis Lassaletta Luis Lassaletta Luis Lassaletta Luis Lassaletta Miryam Calvino Miryam Calvino Silvia Murillo-Cuesta Silvia Murillo-Cuesta Silvia Murillo-Cuesta Isabel Varela-Nieto Isabel Varela-Nieto Isabel Varela-Nieto The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss Frontiers in Aging Neuroscience ARHL GH IGF system presbycusis rare diseases |
| title | The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss |
| title_full | The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss |
| title_fullStr | The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss |
| title_full_unstemmed | The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss |
| title_short | The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss |
| title_sort | role of insulin like growth factor 1 in the progression of age related hearing loss |
| topic | ARHL GH IGF system presbycusis rare diseases |
| url | http://journal.frontiersin.org/article/10.3389/fnagi.2017.00411/full |
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